The SH2-Containing Inositol Polyphosphate 5-Phosphatase, Ship, Is Expressed During Hematopoiesis and Spermatogenesis
Abstract
Ship is a recently identified SH2-containing inositol polyphosphate 5-phosphatase that has been implicated as an important signaling molecule in cell-culture systems. To understand the physiologic function of Ship in vivo, we performed expression studies of Ship during mouse development. Results of this study demonstrate the expression of ship to be in late primitive-streak stage embryos (7.5 days postcoitus [dpc]), when hematopoiesis is thought to begin, and the expression is restricted to the hematopoietic lineage in mouse embryo. In adult mice, Ship expression continues to be in the majority of cells from hematopoietic origin, including granulocytes, monocytes, and lymphocytes, and is also found in the spermatids of the testis. Furthermore, the level of Ship expression is developmentally regulated during T-cell maturation. These results suggest a possible role for Ship in the differentiation and maintenance of the hematopoietic lineages and in spermatogenesis.
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INPP5D is essential for proper hematopoiesis.
“it had first been recognized for being essential for proper hematopoiesis [49].”
From Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease (2023) · cites this paper as [49]
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p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity.
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Liu, Q., Sasaki, T., Kozieradzki, I., Wakeham, A., Itie, A., Dumont, D. J., & Penninger, J. M. (1999) · Genes & Development · doi:10.1101/gad.13.7.786 · Cited by 341 · see citing works
Self-citationStructure, function, and biology of SHIP proteins
Rohrschneider, L. R., Fuller, J. F., Wolf, I., Liu, Y., & Lucas, D. M. (2000) · Genes & Development · doi:10.1101/gad.14.5.505 · Cited by 294 · see citing works
Terzioglu, G., & Young-Pearse, T. L. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00674-9 · Cited by 95 · see citing works
SHIP2 and its involvement in various diseases
Suwa, A., Kurama, T., & Shimokawa, T. (2010) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2010.492780 · Cited by 74 · see citing works
- Authors
- Liu, Q., Shalaby, F., Jones, J., Bouchard, D., & Dumont, D. J.
- Affiliations
- Mount Sinai Hospital (CA)
- ORCID
- Dumont, Daniel J.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1998-04-15
- Volume
- 91
- Issue
- 8
- Pages
- 2753-2759
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2398276155
- Cited by
- 95
- References
- 3
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 1 · 2014: 1 · 2013: 2 · 2012: 5
- FWCI
- 3.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Blood (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- ships, hematopoiesis, spermatogenesis, embryonic development, hematopoietic lineage, T cell development, granulocytes, monocytes, lymphocytes, spermatids, gene expression regulation, mouse embryo
- MeSH terms
- Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases, Animals, Female, Hematopoiesis, Male, Phosphoric Monoester Hydrolases, Pregnancy, Spermatogenesis, In Situ Hybridization, Gene Expression Regulation, Developmental, src Homology Domains, Cell Lineage, Mice
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