The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Role of Adhesion Molecules in the Homing and Mobilization of Murine Hematopoietic Stem and Progenitor Cells
Abstract
Bone marrow (BM) transplantation still must overcome multiple difficulties and should benefit from better understanding of stem-cell homing and mobilization. Here, we analyzed the involvement of several adhesion molecules in the two processes by treating mice with monoclonal antibodies against these molecules. Treatment of lethally irradiated mice grafted with isogeneic BM cells showed that at least two migration pathways are important for stem-cell homing to the BM, whereas only one of them is involved in lodging of colony-forming unit–spleen (CFU-S) in the spleen. We confirm that the VLA-4/VCAM-1 adhesion pathway is important for stem-cell homing to the BM only and show that CD44 is involved in CFU-S lodging in both BM and spleen. These results show that entry of CFU-S into the spleen is regulated. The observation that when one migration pathway is altered, CFU-S do not enter the BM via the other pathway may indicate that the two mechanisms involved in CFU-S homing into the BM are linked. The adhesion molecules VLA-4 and CD44 are also implied in the mobilization of stem cells into the blood stream of mice injected once with anti–VLA-4 or anti-CD44. Anti–VLA-4 administration led to a significant increase in circulating stem cells as early as 8 hours after treatment. Stem cells mobilized by anti–VLA-4 comprise cells with high self-renewal potential and thus may be used for long-term reconstitution of the hematopoietic tissue. © 1998 by The American Society of Hematology.
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Citations
Cites
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Cited by
Chen, J., Li, Y., Wang, L., Zhang, Z., Lu, D., Lu, M., & Chopp, M. (2001) · Stroke · doi:10.1161/01.str.32.4.1005 · Cited by 1,764
Hyaluronan–CD44 interactions as potential targets for cancer therapy
Misra, S., Heldin, P., Hascall, V. C., Karamanos, N. K., Skandalis, S. S., Markwald, R. R., & Ghatak, S. (2011) · The FEBS Journal · doi:10.1111/j.1742-4658.2011.08071.x · Cited by 494
Requirement for CD44 in homing and engraftment of BCR-ABL-expressing leukemic stem cells
Krause, D. S., Lazarides, K., von Andrian, U. H., & Van Etten, R. A. (2006) · Nature Medicine · doi:10.1038/nm1489 · Cited by 349
The Role of Tumor Microenvironment in Multiple Myeloma Development and Progression
García-Ortiz, A., Rodríguez-García, Y., Encinas, J., Maroto-Martín, E., Castellano, E., Teixidó, J., & Martínez-López, J. (2021) · Cancers · doi:10.3390/cancers13020217 · Cited by 238
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Metadata
- Authors
- Vermeulen, M., Le Pesteur, F., Gagnerault, M.-C., Mary, J.-Y., Sainteny, F., & Lepault, F.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 1998-08-01
- Volume
- 92
- Issue
- 3
- Pages
- 894-900
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W71156941
- Cited by
- 290
- References
- 32
- FWCI
- 12.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Role of Adhesion Molecules in the Homing and Mobilization of Murine Hematopoietic Stem and Progenitor Cells. https://app.cochat.ai/papers/10.1182/blood.v92.3.894
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- Vermeulen, M., Le Pesteur, F., Gagnerault, M.-C., Mary, J.-Y., Sainteny, F., & Lepault, F. (1998). Role of Adhesion Molecules in the Homing and Mobilization of Murine Hematopoietic Stem and Progenitor Cells. Blood. https://doi.org/10.1182/blood.v92.3.894
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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