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Cited by 422

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Vascular cell adhesion molecule-1 expressed by bone marrow stromal cells mediates the binding of hematopoietic progenitor cells

Simmons, PJ, Masinovsky, B, Longenecker, BM, Berenson, R, Torok-Storb, B, Gallatin, WM·1992·Blood
DOI 10.1182/blood.v80.2.388.388
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Abstract

Human bone marrow-derived CD34+ cells were analyzed for the expression of the beta 1-family of integrin adhesion molecules. Integrin alpha 4 beta 1 was consistently expressed by greater than 90% of CD34+ cells, including essentially all assayable granulocyte-macrophage colony- forming cells (CFU-GM) and erythroid bursts (BFU-E) as shown by fluorescence-activated cell sorting studies. Adhesion of highly enriched CD34+ cells to cultured allogeneic marrow stromal cells was largely inhibited both by monoclonal antibody to alpha 4 beta 1 and to vascular cell adhesion molecule-1 (VCAM-1), a ligand for alpha 4 beta 1. VCAM-1 was found to be expressed by bone marrow stromal elements in vitro both constitutively at low level and at high levels after treatment with cytokines. Induction of VCAM-1 was cytokine- and time- dependent with maximum levels being obtained after 4 hours of exposure to a combination of interleukin-4 and tumor necrosis factor-alpha. Cytokine-induced stromal cells bound threefold higher numbers of CFU-GM and BFU-E, this increase being abrogated by anti-alpha 4 beta 1 and anti-VCAM-1 antibodies. In addition, the adhesion to stroma of more immature progenitors, the long-term culture initiating cells, also occurred through an alpha 4 beta 1/VCAM-1-dependent mechanism. These studies identify an adhesion mechanism of potential importance in the localization of primitive progenitors within the hematopoietic microenvironment.

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Metadata

Authors
Simmons, P., Masinovsky, B., Longenecker, B., Berenson, R., Torok-Storb, B., & Gallatin, W.
Venue
Blood
Publisher
American Society of Hematology
Published
1992-07-15
Volume
80
Issue
2
Pages
388-395
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
DOI
10.1182/blood.v80.2.388.388
OpenAlex
W1267977458
Cited by
422
References
44
FWCI
6.58
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Vascular cell adhesion molecule-1 expressed by bone marrow stromal cells mediates the binding of hematopoietic progenitor cells. https://app.cochat.ai/papers/10.1182/blood.v80.2.388.388
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Simmons, P., Masinovsky, B., Longenecker, B., Berenson, R., Torok-Storb, B., & Gallatin, W. (1992). Vascular cell adhesion molecule-1 expressed by bone marrow stromal cells mediates the binding of hematopoietic progenitor cells. Blood. https://doi.org/10.1182/blood.v80.2.388.388

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.