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Cited by 511

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Interleukin-10–Treated Human Dendritic Cells Induce a Melanoma-Antigen–Specific Anergy in CD8+ T Cells Resulting in a Failure to Lyse Tumor Cells

Steinbrink, Kerstin, Jonuleit, Helmut, Müller, Gabriele, Schuler, Gerold, Knop, Jürgen, Enk, Alexander H.·1999·Blood
DOI 10.1182/blood.v93.5.1634
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Abstract

Dendritic cells (DC) are critically involved in the initiation of primary immune processes, including tumor rejection. In our study, we investigated the effect of interleukin-10 (IL-10)–treated human DC on the properties of CD8+ T cells that are known to be essential for the destruction of tumor cells. We show that IL-10–pretreatment of DC not only reduces their allostimulatory capacity, but also induces a state of alloantigen-specific anergy in both primed and naive (CD45RA+) CD8+ T cells. To investigate the influence of IL-10–treated DC on melanoma-associated antigen-specific T cells, we generated a tyrosinase-specific CD8+ T-cell line by several rounds of stimulation with the specific antigen. After coculture with IL-10–treated DC, restimulation of the T-cell line with untreated, antigen-pulsed DC demonstrated peptide-specific anergy in the tyrosinase-specific T cells. Addition of IL-2 to the anergic T cells reversed the state of both alloantigen- or peptide-specific anergy. In contrast to optimally stimulated CD8+ T cells, anergic tyrosinase-specific CD8+ T cells, after coculture with peptide-pulsed IL-10–treated DC, failed to lyse an HLA-A2–positive and tyrosinase-expressing melanoma cell line. Thus, our data demonstrate that IL-10–treated DC induce an antigen-specific anergy in cytotoxic CD8+ T cells, a process that might be a mechanism of tumors to inhibit immune surveillance by converting DC into tolerogenic antigen-presenting cells.

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Metadata

Authors
Steinbrink, K., Jonuleit, H., Müller, G., Schuler, G., Knop, J., & Enk, A. H.
Venue
Blood
Publisher
American Society of Hematology
Published
1999-03-01
Volume
93
Issue
5
Pages
1634-1642
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
DOI
10.1182/blood.v93.5.1634
OpenAlex
W333385333
Cited by
511
References
39
FWCI
10.68
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Interleukin-10–Treated Human Dendritic Cells Induce a Melanoma-Antigen–Specific Anergy in CD8+ T Cells Resulting in a Failure to Lyse Tumor Cells. https://app.cochat.ai/papers/10.1182/blood.v93.5.1634
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Steinbrink, K., Jonuleit, H., Müller, G., Schuler, G., Knop, J., & Enk, A. H. (1999). Interleukin-10–Treated Human Dendritic Cells Induce a Melanoma-Antigen–Specific Anergy in CD8+ T Cells Resulting in a Failure to Lyse Tumor Cells. Blood. https://doi.org/10.1182/blood.v93.5.1634

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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