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The Rh blood group system: a review
Abstract
The Rh blood group system is one of the most polymorphic and immunogenic systems known in humans. In the past decade, intense investigation has yielded considerable knowledge of the molecular background of this system. The genes encoding 2 distinct Rh proteins that carry C or c together with either E or e antigens, and the D antigen, have been cloned, and the molecular bases of many of the antigens and of the phenotypes have been determined. A related protein, the Rh glycoprotein is essential for assembly of the Rh protein complex in the erythrocyte membrane and for expression of Rh antigens. The purpose of this review is to provide an overview of several aspects of the Rh blood group system, including the confusing terminology, progress in molecular understanding, and how this developing knowledge can be used in the clinical setting. Extensive documentation is provided to enable the interested reader to obtain further information.
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Cites
Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum
Bianchi, D. W., Zickwolf, G. K., Weil, G. J., Sylvester, S., & DeMaria, M. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.2.705 · Cited by 1,264
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Reproductive mode and the genetic benefits of polyandry
Zeh, J. A., & Zeh, D. W. (2001) · Animal Behaviour · doi:10.1006/anbe.2000.1705 · Cited by 317
The use of cell-free fetal nucleic acids in maternal blood for non-invasive prenatal diagnosis
Wright, C. F., & Burton, H. (2008) · Human Reproduction Update · doi:10.1093/humupd/dmn047 · Cited by 257
Salomao, M., Zhang, X., Yang, Y., Lee, S., Hartwig, J. H., Chasis, J. A., Mohandas, N., & An, X. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803225105 · Cited by 254
Genomic copy number variation, human health, and disease
Wain, L. V., Armour, J. A., & Tobin, M. D. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60249-x · Cited by 196
Inorganic nitrogen assimilation in Chlamydomonas
Fernandez, E., & Galvan, A. (2007) · Journal of Experimental Botany · doi:10.1093/jxb/erm106 · Cited by 177
Metadata
- Authors
- Avent, N. D., & Reid, M. E.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2000-01-15
- Volume
- 95
- Issue
- 2
- Pages
- 375-387
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2147921835
- Cited by
- 704
- References
- 1
- FWCI
- 14.48
- Type
- journal article
- Language
- en
- Open access
- closed
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