The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Chemokine SDF-1 enhances circulating CD34+ cell proliferation in synergy with cytokines: possible role in progenitor survival
Abstract
The chemokine stromal cell-derived factor-1 (SDF-1), and its receptor, CXCR-4, have been implicated in the homing and mobilization of human CD34+ cells. We show here that SDF-1 may also be involved in hematopoiesis, promoting the proliferation of human CD34+ cells purified from normal adult peripheral blood (PB). CXCR-4 was expressed on PB CD34+ cells. The amount of CXCR-4 on PB CD34+ cells was 10 times higher when CD34+ cells were purified following overnight incubation. CXCR-4 overexpression was correlated with a primitive PB CD34+ cell subset defined by a CD34high CD38lowCD71lowc-KitlowThy-1+antigenic profile. The functional significance of CXCR-4 expression was ascertained by assessing the promoting effect of SDF-1 on cell cycle, proliferation, and colony formation. SDF-1 alone increased the percentage of CD34+ cells in the S+G2/M phases and sustained their survival. In synergy with cytokines, SDF-1 increased PB CD34+ and CD34highCD38low cell expansion and colony formation. SDF-1 also stimulated the growth of colonies derived from primitive progenitors released from quiescence by anti–TGF-β treatment. Thus, our results shed new light on the potential role of this chemokine in the stem cell engraftment process, which involves migration, adhesion, and proliferation. Furthermore, both adhesion-induced CXCR-4 overexpression and SDF-1 stimulating activity may be of clinical relevance for improving cell therapy settings in stem cell transplantation.
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Cites
HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor
Feng, Y., Broder, C. C., Kennedy, P. E., & Berger, E. A. (1996) · Science · doi:10.1126/science.272.5263.872 · Cited by 4,172
Nagasawa, T., Hirota, S., Tachibana, K., Takakura, N., Nishikawa, S.-I., Kitamura, Y., Yoshida, N., Kikutani, H., & Kishimoto, T. (1996) · Nature · doi:10.1038/382635a0 · Cited by 2,338
Rollins, B. J. (1997) · Blood · doi:10.1182/blood.v90.3.909 · Cited by 1,984
The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry
Bleul, C. C., Farzan, M., Choe, H., Parolin, C., Clark-Lewis, I., Sodroski, J., & Springer, T. A. (1996) · Nature · doi:10.1038/382829a0 · Cited by 1,953
Oberlin, E., Amara, A., Bachelerie, F., Bessia, C., Virelizier, J.-L., Arenzana-Seisdedos, F., Schwartz, O., Heard, J.-M., Clark-Lewis, I., Legler, D. F., et al. (1996) · Nature · doi:10.1038/382833a0 · Cited by 1,652
Dependence of Human Stem Cell Engraftment and Repopulation of NOD/SCID Mice on CXCR4
Peled, A., Petit, I., Kollet, O., Magid, M., Ponomaryov, T., Byk, T., Nagler, A., Ben-Hur, H., Many, A., Shultz, L., et al. (1999) · Science · doi:10.1126/science.283.5403.845 · Cited by 1,644
A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)
Bleul, C. C., Fuhlbrigge, R. C., Casasnovas, J. M., Aiuti, A., & Springer, T. A. (1996) · The Journal of experimental medicine · doi:10.1084/jem.184.3.1101 · Cited by 1,482
Aiuti, A., Webb, I. J., Bleul, C., Springer, T., & Gutierrez-Ramos, J. C. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.1.111 · Cited by 1,158
Molecular cloning and structure of a pre-B-cell growth-stimulating factor.
Nagasawa, T., Kikutani, H., & Kishimoto, T. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.6.2305 · Cited by 803
Signal Sequence Trap: a Cloning Strategy for Secreted Proteins and Type I Membrane Proteins
Tashiro, K., Tada, H., Heilker, R., Shirozu, M., Nakano, T., & Honjo, T. (1993) · Science · doi:10.1126/science.8342023 · Cited by 713
Cited by
Honczarenko, M., Le, Y., Swierkowski, M., Ghiran, I., Glodek, A. M., & Silberstein, L. E. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0319 · Cited by 722
HGF, SDF-1, and MMP-9 are involved in stress-induced human CD34+ stem cell recruitment to the liver
Kollet, O., Shivtiel, S., Chen, Y.-Q., Suriawinata, J., Thung, S. N., Dabeva, M. D., Kahn, J., Spiegel, A., Dar, A., Samira, S., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17902 · Cited by 593
Kitaori, T., Ito, H., Schwarz, E. M., Tsutsumi, R., Yoshitomi, H., Oishi, S., Nakano, M., Fujii, N., Nagasawa, T., & Nakamura, T. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24330 · Cited by 577
Tavor, S., Petit, I., Porozov, S., Avigdor, A., Dar, A., Leider-Trejo, L., Shemtov, N., Deutsch, V., Naparstek, E., Nagler, A., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3693 · Cited by 363
Lataillade, J.-J., Clay, D., Bourin, P., Hérodin, F., Dupuy, C., Jasmin, C., & Le Bousse-Kerdilès, M.-C. (2002) · Blood · doi:10.1182/blood.v99.4.1117 · Cited by 277
Self-citation
Metadata
- Authors
- Lataillade, J.-J., Clay, D., Dupuy, C., Rigal, S., Jasmin, C., Bourin, P., & Bousse-Kerdilès, M.-C. L.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2000-02-01
- Volume
- 95
- Issue
- 3
- Pages
- 756-768
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1532087698
- Cited by
- 358
- References
- 33
- FWCI
- 10.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lataillade, J.-J., Clay, D., Dupuy, C., Rigal, S., Jasmin, C., Bourin, P., & Bousse-Kerdilès, M.-C. L. (2000). Chemokine SDF-1 enhances circulating CD34+ cell proliferation in synergy with cytokines: possible role in progenitor survival. Blood. https://doi.org/10.1182/blood.v95.3.756
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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