The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Selective elimination of leukemic CD34+ progenitor cells by cytotoxic T lymphocytes specific for WT1
Abstract
Hematologic malignancies such as acute and chronic myeloid leukemia are characterized by the malignant transformation of immature CD34+ progenitor cells. Transformation is associated with elevated expression of the Wilm's tumor gene encoded transcription factor (WT1). Here we demonstrate that WT1 can serve as a target for cytotoxic T lymphocytes (CTL) with exquisite specificity for leukemic progenitor cells. HLA-A0201– restricted CTL specific for WT1 kill leukemia cell lines and inhibit colony formation by transformed CD34+ progenitor cells isolated from patients with chronic myeloid leukemia (CML), whereas colony formation by normal CD34+ progenitor cells is unaffected. Thus, the tissue-specific transcription factor WT1 is an ideal target for CTL-mediated purging of leukemic progenitor cells in vitro and for antigen-specific therapy of leukemia and other WT1-expressing malignancies in vivo.
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Cited by
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Haematological malignancies: at the forefront of immunotherapeutic innovation
Bachireddy, P., Burkhardt, U. E., Rajasagi, M., & Wu, C. J. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3907 · Cited by 85
Metadata
- Authors
- Gao, L., Bellantuono, I., Elsässer, A., Marley, S. B., Gordon, M. Y., Goldman, J. M., & Stauss, H. J.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2000-04-01
- Volume
- 95
- Issue
- 7
- Pages
- 2198-2203
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W159030646
- Cited by
- 408
- References
- 27
- FWCI
- 12.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gao, L., Bellantuono, I., Elsässer, A., Marley, S. B., Gordon, M. Y., Goldman, J. M., & Stauss, H. J. (2000). Selective elimination of leukemic CD34+ progenitor cells by cytotoxic T lymphocytes specific for WT1. Blood. https://doi.org/10.1182/blood.v95.7.2198
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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