The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Probability in transcriptional regulation and its implications for leukocyte differentiation and inducible gene expression
Open accessAbstract
The phenotype of individual hematopoietic cells, like all other differentiated mammalian cells, is determined by selective transcription of a subset of the genes encoded within the genome. This overview summarizes the recent evidence that transcriptional regulation at the level of individual cells is best described in terms of the regulation of the probability of transcription rather than the rate. In this model, heterogeneous gene expression among populations of cells arises by chance, and the degree of heterogeneity is a function of the stability of the mRNA and protein products of individual genes. The probabilistic nature of transcriptional regulation provides one explanation for stochastic phenomena, such as stem cell lineage commitment, and monoallelic expression of inducible genes, such as lymphokines and cytokines.
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Cites
Visualization of Single RNA Transcripts in Situ
Femino, A. M., Fay, F. S., Fogarty, K., & Singer, R. H. (1998) · Science · doi:10.1126/science.280.5363.585 · Cited by 1,504
Kim, T. K., Kim, T. H., & Maniatis, T. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.21.12191 · Cited by 109
Cited by
Interferon-γ: an overview of signals, mechanisms and functions
Schroder, K., Hertzog, P. J., Ravasi, T., & Hume, D. A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0603252 · Cited by 4,120
Self-citationNature, Nurture, or Chance: Stochastic Gene Expression and Its Consequences
Raj, A., & van Oudenaarden, A. (2008) · Cell · doi:10.1016/j.cell.2008.09.050 · Cited by 2,593
Stochasticity in gene expression: from theories to phenotypes
Kærn, M., Elston, T. C., Blake, W. J., & Collins, J. J. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1615 · Cited by 2,320
Stochastic mRNA Synthesis in Mammalian Cells
Raj, A., Peskin, C. S., Tranchina, D., Vargas, D. Y., & Tyagi, S. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040309 · Cited by 1,737
Becskei, A. (2001) · The EMBO Journal · doi:10.1093/emboj/20.10.2528 · Cited by 698
Metadata
- Authors
- Hume, D. A.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2000-10-01
- Volume
- 96
- Issue
- 7
- Pages
- 2323-2328
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1574030551
- Cited by
- 210
- References
- 2
- FWCI
- 4.51
- Type
- journal article
- Language
- en
- Open access
- green
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- Hume, D. A. (2000). Probability in transcriptional regulation and its implications for leukocyte differentiation and inducible gene expression. Blood. https://doi.org/10.1182/blood.v96.7.2323
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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