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Expression of tumor-suppressor genes interferon regulatory factor 1 and death-associated protein kinase in primitive acute myelogenous leukemia cells

Guzman, Monica L., Upchurch, Donna, Grimes, Barry, Howard, Dianna S., Rizzieri, David A., Luger, Selina M., Phillips, Gordon L., Jordan, Craig T.·2001·Blood
DOI 10.1182/blood.v97.7.2177
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Abstract

Previous studies indicate that human acute myelogenous leukemia (AML) arises from a rare population of leukemic stem cells. Cells of this nature can initiate and maintain leukemic cell growth in both long-term cultures and nonobese diabetic/severe combined immune-deficient mice. To characterize the biology of primitive AML cells, gene expression screens were performed with 7 primary AML and 3 normal specimens. For each sample, stem cell populations (CD34+/CD38−) were isolated and used to synthesize radiolabeled complementary DNA (cDNA). AML vs normal probes were then hybridized to cDNA arrays containing genes related to cancer and apoptosis. Of approximately 1400 genes analyzed, 2 tumor-suppressor genes were identified that were overexpressed in all 7 of the AML CD34+/CD38−cell populations: death-associated protein kinase and interferon regulatory factor 1. Expression of each gene was confirmed by reverse-transcription polymerase chain reaction and immunoblot analysis. It is proposed that tumor-suppressor proteins play a role in the biology of primitive AML cells.

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Research works printed but not linked: 20

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Metadata

Authors
Guzman, M. L., Upchurch, D., Grimes, B., Howard, D. S., Rizzieri, D. A., Luger, S. M., Phillips, G. L., & Jordan, C. T.
Venue
Blood
Publisher
American Society of Hematology
Published
2001-04-01
Volume
97
Issue
7
Pages
2177-2179
ISSN
  • 1528-0020
  • 0006-4971
DOI
10.1182/blood.v97.7.2177
Cited by
45
References
1
Language
en

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CoChat. (2026). Citation check: Expression of tumor-suppressor genes interferon regulatory factor 1 and death-associated protein kinase in primitive acute myelogenous leukemia cells. https://app.cochat.ai/papers/10.1182/blood.v97.7.2177
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Guzman, M. L., Upchurch, D., Grimes, B., Howard, D. S., Rizzieri, D. A., Luger, S. M., Phillips, G. L., & Jordan, C. T. (2001). Expression of tumor-suppressor genes interferon regulatory factor 1 and death-associated protein kinase in primitive acute myelogenous leukemia cells. Blood. https://doi.org/10.1182/blood.v97.7.2177