The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor
Abstract
Prostaglandin D2 (PGD2) is released following exposure of asthmatics to allergen and acts via the adenylyl cyclase–coupled receptor for PGD2 (DP receptor). In this study, it is reported that human eosinophils possess this receptor, which would be expected to inhibit their activation. In contrast, it was found that prostaglandin D2 is a potent stimulator of eosinophil chemotaxis, actin polymerization, CD11b expression, and L-selectin shedding. These responses are specific for eosinophils, as neutrophils display little or no response to prostaglandin D2. They were not due to interaction with receptors for other prostanoids, as prostaglandins E2 and F2α, U46619 (a thromboxane A2 analogue), and carbaprostacyclin (a prostacyclin analogue) displayed little or no activity. Furthermore, they were not shared by the selective DP receptor agonist BW245C and were not prevented by the selective DP receptor antagonist BWA868C, indicating that they were not mediated by DP receptors. In contrast, the prostaglandin D2 metabolite 13,14-dihydro-15-oxoprostaglandin D2 induced eosinophil activation but did not stimulate DP receptor–mediated adenosine 3′,5′–cyclic monophosphate (cAMP) formation. These results indicate that in addition to the classic inhibitory DP1 receptor, eosinophils possess a second, novel DP2 receptor that is associated with PGD2-induced cell activation. These 2 receptors appear to interact to regulate eosinophil responses to PGD2, as blockade of DP1 receptor–mediated cAMP production by BWA868C resulted in enhanced DP2receptor–mediated stimulation of CD11b expression. The balance between DP1 and DP2 receptors could determine the degree to which prostaglandin D2 can activate eosinophils and may play a role in eosinophil recruitment in asthma.
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Cites
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Prostaglandin D 2 as a Mediator of Allergic Asthma
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An improved immunomagnetic procedure for the isolation of highly purified human blood eosinophils
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Prostaglandin D2 generation after activation of rat and human mast cells with anti-IgE.
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Cited by
Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology
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Old and new generation lipid mediators in acute inflammation and resolution
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Paracetamol – An old drug with new mechanisms of action
Przybyła, G. W., Szychowski, K. A., & Gmiński, J. (2021) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13392 · Cited by 190
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Eosinophils as a novel cell source of prostaglandin D2: autocrine role in allergic inflammation
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Metadata
- Authors
- Monneret, G., Gravel, S., Diamond, M., Rokach, J., & Powell, W. S.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2001-09-15
- Volume
- 98
- Issue
- 6
- Pages
- 1942-1948
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W2066882388
- Cited by
- 326
- References
- 36
- FWCI
- 9.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Monneret, G., Gravel, S., Diamond, M., Rokach, J., & Powell, W. S. (2001). Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor. Blood. https://doi.org/10.1182/blood.v98.6.1942
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