Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

VANE, J. R. (1971) · Nature New Biology · doi:10.1038/newbio231232a0 · Cited by 8,605 · see citing works

Cyclooxygenases: Structural, cellular, and molecular biology

Smith, W. L., DeWitt, D. L., & Garavito, R. M. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.145 · Cited by 2,925 · see citing works

Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation

Samuelsson, B. O. (1983) · Science · doi:10.1126/science.6301011 · Cited by 2,858 · see citing works

15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ

FORMAN, B. M., Tontonoz, P., Chen, J., Brun, R. P., Spiegelman, B. M., & Evans, R. M. (1995) · Cell · doi:10.1016/0092-8674(95)90193-0 · Cited by 2,858 · see citing works

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

Kliewer, S. A., Lenhard, J. M., Willson, T. M., Patel, I., Morris, D. C., & Lehmann, J. M. (1995) · Cell · doi:10.1016/0092-8674(95)90194-9 · Cited by 2,028 · see citing works

The Coxibs, Selective Inhibitors of Cyclooxygenase-2

FitzGerald, G. A., & Patrono, C. (2001) · New England Journal of Medicine · doi:10.1056/nejm200108093450607 · Cited by 1,572 · see citing works

Lipid mediator class switching during acute inflammation: signals in resolution

Levy, B. D., Clish, C. B., Schmidt, B., Gronert, K., & Serhan, C. N. (2001) · Nature Immunology · doi:10.1038/89759 · Cited by 1,453 · see citing works

A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity

Weggen, S., Eriksen, J. L., Das, P., Sagi, S. A., Wang, R., Pietrzik, C. U., Findlay, K. A., Smith, T. E., Murphy, M. P., Bulter, T., et al. (2001) · Nature · doi:10.1038/35102591 · Cited by 1,388 · see citing works

The expanding superfamily of phospholipase A2 enzymes: classification and characterization

Six, D. A., & Dennis, E. A. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00105-0 · Cited by 1,359 · see citing works

The PPARα–leukotriene B4 pathway to inflammation control

Devchand, P. R., Keller, H., Peters, J. M., Vazquez, M., Gonzalez, F. J., & Wahli, W. (1996) · Nature · doi:10.1038/384039a0 · Cited by 1,345 · see citing works

Inducible cyclooxygenase may have anti-inflammatory properties

Gilroy, D. W., Colville‐Nash, P., Willis, D., Chivers, J. E., Paul‐Clark, M. J., & Willoughby, D. A. (1999) · Nature Medicine · doi:10.1038/9550 · Cited by 1,243 · see citing works

Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2

Hirai, H., Tanaka, K., Yoshie, O., Ogawa, K., Kenmotsu, K., Takamori, Y., Ichimasa, M., Sugamura, K., Nakamura, M., Takano, S., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.2.255 · Cited by 1,101 · see citing works

PPARδ Is an APC-Regulated Target of Nonsteroidal Anti-Inflammatory Drugs

He, T., Chan, T. A.-T., Vogelstein, B., & Kinzler, K. W. (1999) · Cell · doi:10.1016/s0092-8674(00)81664-5 · Cited by 1,083 · see citing works

Identification of human prostaglandin E synthase: A microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target

Jakobsson, P., Thorén, S., Morgenstern, R., & Samuelsson, B. O. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7220 · Cited by 995 · see citing works

ON THE NATURE AND RÔLE OF THE FATTY ACIDS ESSENTIAL IN NUTRITION

Burr, G. O., & Burr, M. M. (1930) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)78929-5 · Cited by 981 · see citing works

A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis

Yokomizo, T., Izumi, T., Chang, K., Takuwa, Y., & Shimizu, T. (1997) · Nature · doi:10.1038/42506 · Cited by 971 · see citing works

Characterization of the human cysteinyl leukotriene CysLT1 receptor

Lynch, K. R., O’Neill, G. P., Liu, Q., Im, D., Sawyer, N., Metters, K. M., Coulombe, N., Abramovitz, M., Figueroa, D. J., Zeng, Z., et al. (1999) · Nature · doi:10.1038/21658 · Cited by 965 · see citing works

Treatment of Asthma with Drugs Modifying the Leukotriene Pathway

Drazen, J. M., Israel, E., & O’Byrne, P. M. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901213400306 · Cited by 823 · see citing works

Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes

Tilley, S. L., Coffman, T. M., & Koller, B. H. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200113416 · Cited by 728 · see citing works

Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes

Tilley, S. L., Coffman, T. M., & Koller, B. H. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13416 · Cited by 725 · see citing works

Differential Activation of Peroxisome Proliferator-activated Receptors by Eicosanoids

Yu, K., Bayona, W., Kallen, C. B., Harding, H. P., Ravera, C., McMahon, G., Brown, M. A., & Lazar, M. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.41.23975 · Cited by 709 · see citing works

Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3

Ushikubi, F., Segi, E., Sugimoto, Y., Murata, T., Matsuoka, T., Kobayashi, T., Hizaki, H., Tuboi, K., Katsuyama, M., Ichikawa, A., et al. (1998) · Nature · doi:10.1038/26233 · Cited by 677 · see citing works

Characterization of the Human Cysteinyl Leukotriene 2 Receptor

Heise, C. E., O’Dowd, B. F., Figueroa, D. J., Sawyer, N., Nguyen, T., Im, D., Stocco, R., Bellefeuille, J. N., Abramovitz, M., Cheng, R., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003490200 · Cited by 660 · see citing works

Epoxygenase Pathways of Arachidonic Acid Metabolism

Zeldin, D. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r100030200 · Cited by 655 · see citing works

Genetic and pharmacological analysis of prostanoid receptor function

Narumiya, S., & FitzGerald, G. A. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13455 · Cited by 568 · see citing works

Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment

Drazen, J. M., Yandava, C., Dubé, L. M., Szczerbak, N., Hippensteel, R., Pillari, A., Israel, E., Schork, N. J., Silverman, E. S., Katz, D. A., et al. (1999) · Nature Genetics · doi:10.1038/9680 · Cited by 561 · see citing works

A Second Leukotriene B4 Receptor, Blt2

Yokomizo, T., Kato, K., Terawaki, K., Izumi, T., & Shimizu, T. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.3.421 · Cited by 540 · see citing works

The enzymatic formation of prostaglandin E2 from arachidonic acid prostaglandins and related factors 32

Bergström, S., Danielsson, H., & Samuelsson, B. O. (1964) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(64)90145-x · Cited by 483 · see citing works

Genetic and pharmacological analysis of prostanoid receptor function

Narumiya, S., & FitzGerald, G. A. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200113455 · Cited by 476 · see citing works

The Leukotriene C4 Transporter MRP1 Regulates CCL19 (MIP-3β, ELC)–Dependent Mobilization of Dendritic Cells to Lymph Nodes

Robbiani, D. F., Finch, R. A., Jäger, D., Müller, W. A., Sartorelli, A. C., & Randolph, G. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00179-3 · Cited by 455 · see citing works

Prostacyclin-mediated activation of peroxisome proliferator-activated receptor δ in colorectal cancer

Gupta, R. A., Tan, J., Krause, W. F., Geraci, M. W., Willson, T. M., Dey, S. K., & DuBois, R. N. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.24.13275 · Cited by 401 · see citing works

Pathway across the blood–brain barrier

Ek, M., Engblom, D., Saha, S., Blomqvist, A. G., Jakobsson, P., & Ericsson‐Dahlstrand, A. (2001) · Nature · doi:10.1038/35068632 · Cited by 347 · see citing works

Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor

Monneret, G., Gravel, S., Diamond, M. P., Rokach, J., & Powell, W. S. (2001) · Blood · doi:10.1182/blood.v98.6.1942 · Cited by 324 · see citing works

Arachidonic Acid Is Preferentially Metabolized by Cyclooxygenase-2 to Prostacyclin and Prostaglandin E2

Brock, T. G., McNish, R. W., & Peters-Golden, M. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.17.11660 · Cited by 306 · see citing works

Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation.

Thunnissen, M. M. G. M., Nordlund, P., & Haeggström, J. Z. (2001) · Nature Structural Biology · doi:10.1038/84117 · Cited by 300 · see citing works

Biochemical Studies of Human Semen. II. The Action of Semen on the Human Uterus.

Kurzrok, R., & Lieb, C. C. (1930) · Experimental Biology and Medicine · doi:10.3181/00379727-28-5265 · Cited by 288 · see citing works

Intracellular Calcium Signals Regulating Cytosolic Phospholipase A2 Translocation to Internal Membranes

Evans, J. H., Spencer, D. M., Zweifach, A., & Leslie, C. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100943200 · Cited by 260 · see citing works

Cloning, Expression, and Up-regulation of Inducible Rat Prostaglandin E Synthase during Lipopolysaccharide-induced Pyresis and Adjuvant-induced Arthritis

Mancini, J. A., Blood, K., Guay, J., Gordon, R. J., Claveau, D., Chan, C., & Riendeau, D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006865200 · Cited by 246 · see citing works

Nuclear localization of prostaglandin E 2 receptors

Bhattacharya, M., Peri, K. G., Almazán, G., Ribeiro‐da‐Silva, A., Shichi, H., Durocher, Y., Abramovitz, M., Hou, X., Varma, D. R., & Chemtob, S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15792 · Cited by 240 · see citing works

Characterization of the human 5-lipoxygenase gene.

Funk, C. D., Hoshiko, S., Matsumoto, T., R�dmark, O., & Samuelsson, B. O. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.8.2587 · Cited by 212 · see citing works

Distribution and function of prostanoid receptors: studies from knockout mice

Sugimoto, Y., Narumiya, S., & Ichikawa, A. (2000) · Progress in Lipid Research · doi:10.1016/s0163-7827(00)00008-4 · Cited by 192 · see citing works

MOLECULAR MECHANISMS OF PROSTAGLANDIN TRANSPORT

Schuster, V. L. (1998) · Annual Review of Physiology · doi:10.1146/annurev.physiol.60.1.221 · Cited by 188 · see citing works

Cysteinyl leukotriene receptor 1 is also a pyrimidinergic receptor and is expressed by human mast cells

Mellor, E. A., Maekawa, A., Austen, K. F., & Boyce, J. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.141221498 · Cited by 179 · see citing works

Selectivity of Recombinant Human Leukotriene D4, Leukotriene B4, and Lipoxin A4 Receptors with Aspirin-Triggered 15-epi-LXA4 and Regulation of Vascular and Inflammatory Responses

Gronert, K., Niskanen, T. M., Ravasi, S., Chiang, N., & Serhan, C. N. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63937-5 · Cited by 167 · see citing works

The N-terminal Domain of 5-Lipoxygenase Binds Calcium and Mediates Calcium Stimulation of Enzyme Activity*

Hammarberg, T., Provost, P., Persson, B., & Rådmark, O. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006136200 · Cited by 165 · see citing works

Addition of leukotriene antagonists to therapy in chronic persistent asthma: a randomised double-blind placebo-controlled trial

Robinson, D. S., Campbell, D., & Barnes, P. J. (2001) · The Lancet · doi:10.1016/s0140-6736(00)05113-8 · Cited by 159 · see citing works

The Effect of Sodium Salicylate and Aspirin on NF-κB

Frantz, B., & O’Neill, E. A. (1995) · Science · doi:10.1126/science.270.5244.2017 · Cited by 158 · see citing works

Unorthodox routes to prostanoid formation: new twists in cyclooxygenase-initiated pathways

Serhan, C. N., & Oliw, E. H. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13375 · Cited by 146 · see citing works

Intracellular compartmentalization of leukotriene synthesis: unexpected nuclear secrets

Peters-Golden, M. L., & Brock, T. G. (2001) · FEBS Letters · doi:10.1016/s0014-5793(00)02374-7 · Cited by 126 · see citing works

12/15-Lipoxygenase, Oxidative Modification of LDL and Atherogenesis

Cyrus, C. (2001) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(01)00096-2 · Cited by 125 · see citing works

The N-terminal “β-Barrel” Domain of 5-Lipoxygenase Is Essential for Nuclear Membrane Translocation

Chen, X., & Funk, C. D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008203200 · Cited by 122 · see citing works

Differential Regulation of Prostaglandin E2 and Thromboxane A2 Production in Human Monocytes: Implications for the Use of Cyclooxygenase Inhibitors

Penglis, P. S., Cleland, L. G., Demasi, M., Caughey, G. E., & James, M. J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.3.1605 · Cited by 108 · see citing works

Cyclooxygenases in the Central Nervous System: Implications for Treatment of Neurological Disorders

Yermakova, A., & O’Banion, M. K. (2000) · Current Pharmaceutical Design · doi:10.2174/1381612003398672 · Cited by 94 · see citing works

Acute tubulointerstitial nephritis associated with the selective COX-2 enzyme inhibitor, rofecoxib

Rocha, J. L., & Fernández-Alonso, J. (2001) · The Lancet · doi:10.1016/s0140-6736(00)05083-2 · Cited by 92 · see citing works

NSAIDS and selective COX-2 inhibitors: competition between gastroprotection and cardioprotection

Boers, M. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04451-2 · Cited by 70 · see citing works

An adrenaline‐like action in extracts from the prostatic and related glands

von Euler, U. S. (1934) · The Journal of Physiology · doi:10.1113/jphysiol.1934.sp003119 · Cited by 55 · see citing works

Transcellular Regulation of Eicosanoid Biosynthesis

Gronert, K., Clish, C. B., Romano, M., & Serhan, C. N. (2003) · Humana Press eBooks · doi:10.1385/1-59259-263-5:119 · Cited by 54 · see citing works

Insight into prostaglandin, leukotriene, and other eicosanoid functions using mice with targeted gene disruptions☆

Austin, S. C., & Funk, C. D. (1999) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s0090-6980(99)00041-6 · Cited by 52 · see citing works

Telling the brain about pain

Bartfai, T. (2001) · Nature · doi:10.1038/35068663 · Cited by 46 · see citing works

Significance of lipoxygenase-derived monohydroxy fatty acids in cutaneous biology

Ziboh, V. A., Miller, C. C., & Cho, Y. (2000) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s0090-6980(00)00093-9 · Cited by 44 · see citing works

COX-2 inhibition and prevention of cancer

Giercksky, K.-E. (2001) · Best Practice & Research Clinical Gastroenterology · doi:10.1053/bega.2001.0237 · Cited by 42 · see citing works

Efficacy of antileukotriene agents in asthma management

Nathan, R. A., & Kemp, J. P. (2001) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)62306-x · Cited by 37 · see citing works

The Biochemical, Molecular, and Genomic Aspects of Leukotriene C4 Synthase

Penrose, J. F., & Austen, K. F. (1999) · Proceedings of the Association of American Physicians · doi:10.1046/j.1525-1381.1999.99212.x · Cited by 34 · see citing works

Cloning and Characterization of a Bifunctional Leukotriene A4 Hydrolase from Saccharomyces cerevisiae

Kull, F., Ohlson, E., & Haeggström, J. Z. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.49.34683 · Cited by 33 · see citing works

Leukotriene antagonists and symptom control in chronic persistent asthma

Green, R. H., & Pavord, I. D. (2001) · The Lancet · doi:10.1016/s0140-6736(00)05132-1 · Cited by 20 · see citing works

Resolution of inflammation: the beginning programs the end

Serhan, C. N., & Savill, J. (2005) · Nature Immunology · doi:10.1038/ni1276 · Cited by 2,552 · see citing works

Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases

Bhattacharyya, A., Chattopadhyay, R., Mitra, S., & Crowe, S. E. (2014) · Physiological Reviews · doi:10.1152/physrev.00040.2012 · Cited by 2,484 · see citing works

Endometriosis

Bulun, S. E. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804690 · Cited by 1,772 · see citing works

The COX-2/PGE2 pathway, key roles in the hallmarks of cancer and adaptation to the tumour microenvironment

Greenhough, A., Smartt, H. J. M., Moore, A. E., Roberts, H. R., Williams, A. C., Paraskeva, C., & Kaidi, A. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp014 · Cited by 1,220 · see citing works

Phagocyte partnership during the onset and resolution of inflammation

Soehnlein, O., & Lindbom, L. (2010) · Nature Reviews Immunology · doi:10.1038/nri2779 · Cited by 1,054 · see citing works

Identification of bioactive metabolites using activity metabolomics

Rinschen, M. M., Ivanisevic, J., Giera, M., & Siuzdak, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0108-4 · Cited by 1,008 · see citing works

Phospholipase A2 structure/function, mechanism, and signaling

Burke, J. E., & Dennis, E. A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800033-jlr200 · Cited by 933 · see citing works

Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease

Haeggström, J. Z., & Funk, C. D. (2011) · Chemical Reviews · doi:10.1021/cr200246d · Cited by 875 · see citing works

Microalgae Metabolites: A Rich Source for Food and Medicine

Sathasivam, R., Radhakrishnan, R., Hashem, A., & Abd_Allah, E. F. (2019) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2017.11.003 · Cited by 872 · see citing works

Endometriosis

Bulun, S. E., Yilmaz, B. D., Sison, C., Miyazaki, K., Bernardi, L., Liu, S., Kohlmeier, A., Yin, P., Milad, M., & Wei, J. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00242 · Cited by 844 · see citing works

Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation

Boudreau, L. H., Duchez, A.-C., Cloutier, N., Soulet, D., Martin, N., Bollinger, J., Paré, A., Rousseau, M., Naika, G. S., Lévesque, T., et al. (2014) · Blood · doi:10.1182/blood-2014-05-573543 · Cited by 703 · see citing works

Kaempferol and inflammation: from chemistry to medicine

Devi, K. P., Malar, D. S., Nabavi, S. F., Sureda, A., Xiao, J., Nabavi, S. M., & Daglia, M. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.05.002 · Cited by 619 · see citing works

Metabolic landscape of the tumor microenvironment at single cell resolution

Xiao, Z., Dai, Z., & Locasale, J. W. (2019) · Nature Communications · doi:10.1038/s41467-019-11738-0 · Cited by 524 · see citing works

Essential fatty acids as functional components of foods- a review

Kaur, N., Chugh, V., & Gupta, A. K. (2014) · Journal of Food Science and Technology · doi:10.1007/s13197-012-0677-0 · Cited by 490 · see citing works

Myeloperoxidase functions as a major enzymatic catalyst for initiation of lipid peroxidation at sites of inflammation

Zhang, R., Brennan, M.-L., Shen, Z., MacPherson, J. C., Schmitt, D., Molenda, C. E., & Hazen, S. L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209124200 · Cited by 432 · see citing works

Identification of 5-Lipoxygenase as a Major Gene Contributing to Atherosclerosis Susceptibility in Mice

Mehrabian, M., Allayee, H., Wong, J., Shih, W., Wang, X.-P., Shaposhnik, Z., Funk, C. D., & Lusis, A. J. (2002) · Circulation Research · doi:10.1161/01.res.0000028008.99774.7f · Cited by 422 · see citing works

Novel Lipid Mediators and Resolution Mechanisms in Acute Inflammation

Serhan, C. N. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.100322 · Cited by 421 · see citing works

Polyunsaturated fatty acid synthesis: What will they think of next?

Wallis, J. G., Watts, J. L., & Browse, J. (2002) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(02)02168-0 · Cited by 375 · see citing works

Immunomodulating activities of acidic sulphated polysaccharides obtained from the seaweed Ulva rigida C. Agardh

Leiro, J. M., Castro, R., Arranz, J. A., & Lamas, J. (2007) · International Immunopharmacology · doi:10.1016/j.intimp.2007.02.007 · Cited by 316 · see citing works

Stepwise engineering to produce high yields of very long-chain polyunsaturated fatty acids in plants

Wu, G., Truksa, M., Datla, N., Vrinten, P., Bauer, J., Zank, T., Cirpus, P., Heinz, E., & Qiu, X. (2005) · Nature Biotechnology · doi:10.1038/nbt1107 · Cited by 310 · see citing works

Association between fatty acid metabolism in the brain and Alzheimer disease neuropathology and cognitive performance: A nontargeted metabolomic study

Snowden, S. G., Ebshiana, A. A., Hye, A., An, Y., Pletnikova, O., O’Brien, R., Troncoso, J., Legido-Quigley, C., & Thambisetty, M. (2017) · PLOS Medicine · doi:10.1371/journal.pmed.1002266 · Cited by 309 · see citing works

Boosting intracellular delivery of lipid nanoparticle-encapsulated mRNA

Patel, S., Ashwanikumar, N., Robinson, E., DuRoss, A., Sun, C., Murphy-Benenato, K. E., Mihai, C., Almarsson, Ö., & Sahay, G. (2017) · Nano Letters · doi:10.1021/acs.nanolett.7b02664 · Cited by 251 · see citing works

New insights into the mechanism of action of acetaminophen: Its clinical pharmacologic characteristics reflect its inhibition of the two prostaglandin H2 synthases

ARONOFF, D., OATES, J., & BOUTAUD, O. (2006) · Clinical Pharmacology & Therapeutics · doi:10.1016/j.clpt.2005.09.009 · Cited by 222 · see citing works

Paracetamol – An old drug with new mechanisms of action

Przybyła, G. W., Szychowski, K. A., & Gmiński, J. (2021) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13392 · Cited by 190 · see citing works

Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis

Wiley, C. D., Sharma, R., Davis, S. S., Lopez-Dominguez, J. A., Mitchell, K. P., Wiley, S., Alimirah, F., Kim, D. E., Payne, T., Rosko, A., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.03.008 · Cited by 173 · see citing works

Medical Management of Endometriosis

RAFIQUE, S., & DECHERNEY, A. H. (2017) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0000000000000292 · Cited by 173 · see citing works

The Role of COX-2 and PGE2 in the Regulation of Immunomodulation and Other Functions of Mesenchymal Stromal Cells

Kulesza, A., Paczek, L., & Burdzinska, A. (2023) · Biomedicines · doi:10.3390/biomedicines11020445 · Cited by 163 · see citing works

Prostaglandin E ₂ glycerol ester, an endogenous COX‐2 metabolite of 2‐arachidonoylglycerol, induces hyperalgesia and modulates NFκB activity

Hu, S. S., Bradshaw, H. B., Chen, J. S., Tan, B., & Walker, J. M. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.33 · Cited by 151 · see citing works

Menstruation pulls the trigger for inflammation and pain in endometriosis

Laux-Biehlmann, A., d’Hooghe, T., & Zollner, T. M. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.03.004 · Cited by 150 · see citing works

Omega-3 polyunsaturated fatty acids as a treatment strategy for nonalcoholic fatty liver disease

Jump, D. B., Lytle, K. A., Depner, C. M., & Tripathy, S. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.07.007 · Cited by 142 · see citing works

A systematic review of the effect of Centella asiatica on wound healing

Arribas-López, E., Zand, N., Ojo, O., Snowden, M. J., & Kochhar, T. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19063266 · Cited by 143 · see citing works

N-3 (Omega-3) Fatty Acids: Effects on Brain Dopamine Systems and Potential Role in the Etiology and Treatment of Neuropsychiatric Disorders

Healy-Stoffel, M., & Levant, B. (2018) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527317666180412153612 · Cited by 133 · see citing works

Skin homeostasis: Mechanism and influencing factors

Jiao, Q., Zhi, L., You, B., Wang, G., Wu, N., & Jia, Y. (2024) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.16155 · Cited by 134 · see citing works

Metabolomic Assessment of Induced and Activated Chemical Defence in the Invasive Red Alga Gracilaria vermiculophylla

Nylund, G. M., Weinberger, F., Rempt, M., & Pohnert, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029359 · Cited by 117 · see citing works

Pain management in patients with inflammatory bowel disease: insights for the clinician

Srinath, A. I., Walter, C., Newara, M. C., & Szigethy, E. M. (2012) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x12446158 · Cited by 111 · see citing works

The 5-lipoxygenase pathway in arterial wall biology and atherosclerosis

LOTZER, K., FUNK, C., & HABENICHT, A. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2005.07.001 · Cited by 108 · see citing works

Vertebrate Membrane Proteins: Structure, Function, and Insights from Biophysical Approaches

Müller, D. J., Wu, N., & Palczewski, K. (2008) · Pharmacological Reviews · doi:10.1124/pr.107.07111 · Cited by 104 · see citing works

Maternal serum metabolome and traffic-related air pollution exposure in pregnancy

Yan, Q., Liew, Z., Uppal, K., Cui, X., Ling, C., Heck, J. E., von Ehrenstein, O. S., Wu, J., Walker, D. I., Jones, D. P., et al. (2019) · Environment International · doi:10.1016/j.envint.2019.05.066 · Cited by 91 · see citing works

Activation of multidrug efflux transporter activity at fertilization in sea urchin embryos (Strongylocentrotus purpuratus)

Hamdoun, A. M., Cherr, G. N., Roepke, T. A., & Epel, D. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.09.013 · Cited by 91 · see citing works

The tumor suppressor gene H-Rev107 functions as a novel Ca2+-independent cytosolic phospholipase A1/2 of the thiol hydrolase type

Uyama, T., Morishita, J., Jin, X.-H., Okamoto, Y., Tsuboi, K., & Ueda, N. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800453-jlr200 · Cited by 84 · see citing works

Investigating the human immunodeficiency virus type 1-infected monocyte-derived macrophage secretome

Ciborowski, P., Kadiu, I., Rozek, W., Smith, L., Bernhardt, K., Fladseth, M., Ricardo-Dukelow, M., & Gendelman, H. E. (2007) · Virology · doi:10.1016/j.virol.2007.01.013 · Cited by 87 · see citing works

Relief for fish stocks: Oceanic fatty acids in transgenic oilseeds

Domergue, F., Abbadi, A., & Heinz, E. (2005) · Trends in Plant Science · doi:10.1016/j.tplants.2005.01.003 · Cited by 84 · see citing works

Urinary Prostaglandin F2α Is Generated from the Isoprostane Pathway and Not the Cyclooxygenase in Humans

Yin, H., Gao, L., Tai, H.-H., Murphey, L. J., Porter, N. A., & Morrow, J. D. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608975200 · Cited by 82 · see citing works

Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes

Uyama, T., Jin, X.-H., Tsuboi, K., Tonai, T., & Ueda, N. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.07.001 · Cited by 80 · see citing works

Engineering Oilseed Plants for a Sustainable, Land‐Based Source of Long Chain Polyunsaturated Fatty Acids

Damude, H. G., & Kinney, A. J. (2007) · Lipids · doi:10.1007/s11745-007-3049-1 · Cited by 78 · see citing works

Soluble epoxide hydrolase is an endogenous regulator of obesity-induced intestinal barrier dysfunction and bacterial translocation

Wang, Y., Yang, J., Wang, W., Sanidad, K. Z., Cinelli, M. A., Wan, D., Hwang, S. H., Kim, D., Lee, K. S. S., Xiao, H., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1916189117 · Cited by 59 · see citing works

Lipid profiling of polarized human monocyte-derived macrophages

Montenegro-Burke, J. R., Sutton, J. A., Rogers, L. M., Milne, G. L., McLean, J. A., & Aronoff, D. M. (2016) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2016.11.002 · Cited by 44 · see citing works

Lipid accumulation by Coelastrella multistriata (Scenedesmaceae, Sphaeropleales) during nitrogen and phosphorus starvation

Maltsev, Y., Krivova, Z., Maltseva, S., Maltseva, K., Gorshkova, E., & Kulikovskiy, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-99376-9 · Cited by 40 · see citing works

Exogenous arachidonic acid mediates permeability of human brain microvessel endothelial cells through prostaglandin E ₂ activation of <scp>EP</scp> ₃ and <scp>EP</scp> ₄ receptors

Dalvi, S., Nguyen, H. H., On, N., Mitchell, R. W., Aukema, H. M., Miller, D. W., & Hatch, G. M. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13117 · Cited by 37 · see citing works

The production of long chain polyunsaturated fatty acids in transgenic plants by reverse-engineering

Napier, J. A., Beaudoin, F., Michaelson, L. V., & Sayanova, O. (2004) · Biochimie · doi:10.1016/j.biochi.2004.09.020 · Cited by 36 · see citing works

Resolving neuroinflammation, the therapeutic potential of the anti-malaria drug family of artemisinin

Shi, Z., Chen, Y., Lu, C., Dong, L.-M., Lv, J.-W., Tuo, Q.-H., Qin, L., Cheng, S.-W., Bu, L.-L., Lin, N., et al. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.09.002 · Cited by 32 · see citing works

Effect of the dietary intake of melatonin- and hydroxytyrosol-rich wines by healthy female volunteers on the systemic lipidomic-related oxylipins

Marhuenda, J., Medina, S., Martínez-Hernández, P., Arina, S., Zafrilla, P., Mulero, J., Oger, C., Galano, J.-M., Durand, T., Solana, A., et al. (2017) · Food Funct. · doi:10.1039/c7fo01081h · Cited by 22 · see citing works

UPLC-MS/MS-based profiling of eicosanoids in RAW264.7 cells treated with lipopolysaccharide

Lee, J., Mok, H., Lee, D.-Y., Park, S., Ban, M., Choi, J., Park, C., Ahn, Y.-S., Kim, K., & Kim, H. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17040508 · Cited by 22 · see citing works

Anaphylaxis: Mediators, Biomarkers, and Microenvironments

Fernandez-Bravo, S., Palacio-Garcia, L., Requena-Robledo, N., Yuste-Montalvo, A., Nuñez-Borque, E., & Esteban, V (2022) · Journal of Investigational Allergology and Clinical Immunology · doi:10.18176/jiaci.0854 · Cited by 17 · see citing works

Bioactive Compounds and Diabetes Mellitus: Prospects and Future Challenges

Rahman, M. M., Islam, M. R., Rabbi, F., Islam, M. T., Sultana, S., Ahmed, M., Sehgal, A., Singh, S., Sharma, N., & Behl, T. (2022) · Current Pharmaceutical Design · doi:10.2174/1381612828666220412090808 · Cited by 13 · see citing works

Analysis of the effects of dietary fat on body and skin lipids of hamsters by Raman spectroscopy

Meksiarun, P., Maeda, Y., Hiroi, T., Andriana, B. B., & Sato, H. (2015) · The Analyst · doi:10.1039/c5an00076a · Cited by 14 · see citing works

Unraveling the link between neuropathy target esterase NTE/SWS, lysosomal storage diseases, inflammation, abnormal fatty acid metabolism, and leaky brain barrier

Tsap, M. I., Yatsenko, A. S., Hegermann, J., Beckmann, B., Tsikas, D., & Shcherbata, H. R. (2024) · eLife · doi:10.7554/elife.98020 · Cited by 8 · see citing works

Ceramide and Ceramide‐1‐phosphate: Enigmatic Lipids Generating New Signaling Paradigms

Chalfant, C. E. (2011) · The FASEB Journal · doi:10.1096/fasebj.25.1_supplement.197.3

Lipid Mediators Are Critical in Resolving Inflammation: A Review of the Emerging Roles of Eicosanoids in Diabetes Mellitus

Tessaro, F. H. G., Ayala, T. S., & Martins, J. O. (2015) · BioMed Research International · doi:10.1155/2015/568408 · Cited by 63 · see citing works

Metabolomics‐Lipidomics of Eicosanoids and Docosanoids Generated by Phagocytes

Yang, R., Chiang, N., Oh, S. F., & Serhan, C. N. (2011) · Current Protocols in Immunology · doi:10.1002/0471142735.im1426s95 · Cited by 104 · see citing works

Lipid mediator class switching during acute inflammation: signals in resolution

Levy, B. D., Clish, C. B., Schmidt, B., Gronert, K., & Serhan, C. N. (2001) · Nature Immunology · doi:10.1038/89759 · Cited by 1,453 · see citing works

Eicosanoid and Bioactive Lipid Mediators

(2014) · doi:10.1039/9781782626350-00040 · Cited by 5 · see citing works