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Distinctive features of “nurselike” cells that differentiate in the context of chronic lymphocytic leukemia.

Tsukada, Nobuhiro, Burger, Jan A., Zvaifler, Nathan J., Kipps, Thomas J.·2002·Blood
DOI 10.1182/blood.v99.3.1030
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Abstract

A subset of blood mononuclear cells from patients with chronic lymphocytic leukemia (CLL) can differentiate in vitro into “nurselike” cells (NLCs) that can protect CLL cells from apoptosis. NLCs express cytoplasmic vimentin and stromal-derived factor 1 (SDF-1). NLCs also express CD14, as well as CD11b, CD33, CD40, CD45RO, CD68, CD80, CD86, HLA-DQ, and HLA-DR, but not CD1a, CD2, CD3, CD11c, CD19, CD45RA, CD83, CD106, or CD154. Consistent with this phenotype, NLCs failed to differentiate from blood mononuclear cells that were depleted of CD14+ cells or from isolated CD19+cells. CD14+ blood cells of healthy donors could differentiate into cells with the morphology and phenotype of NLCs when cultured in direct contact with CLL B cells, but not with normal B cells. Despite expressing antigens in common with blood monocytes, monocyte-derived dendritic cells, and macrophages, NLCs expressed significantly higher levels of CD68 than these other cell types. Consistent with the notion that NLCs are present in vivo, CD14+ splenocytes from CLL patients have NLC morphology and express significantly higher levels of CD68 than CD14+splenocytes from persons without known B-cell malignancy. These findings indicate that although NLCs may differentiate from blood monocytes, they probably represent a distinctive hematopoietic cell type that exists in vivo, differentiates from hematopoietic CD14+ cells in the context of CLL, and in turn protect CLL cells from apoptosis via a mechanism that is independent of CD106 (vascular cell adhesion molecule-1). The interaction between CLL cells and NLCs may represent a novel target for therapy of patients with this disease.

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Cited by

Metadata

Authors
Tsukada, N., Burger, J. A., Zvaifler, N. J., & Kipps, T. J.
Affiliations
From the Department of Medicine, Division of Hematology/Oncology, and Division of Rheumatology, Allergy, and Immunology, University of California, San Diego, La Jolla, and Department of Medicine, Freiburg University, Germany.
Venue
Blood
Publisher
American Society of Hematology
Published
2002-02-01
Volume
99
Issue
3
Pages
1030-1037
ISSN
  • 1528-0020
  • 0006-4971
DOI
10.1182/blood.v99.3.1030
Cited by
226
References
0
Language
en

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