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Cited by 1,100

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

WHO guidelines for the programmatic management of drug-resistant tuberculosis: 2011 update

Open access
Falzon, D., Jaramillo, E., Schünemann, H.J., Arentz, M., Bauer, M., Bayona, J., Blanc, L., Caminero, J.A., Daley, C.L., Duncombe, C., Fitzpatrick, C., Gebhard, A., Getahun, H., Henkens, M., Holtz, T.H., Keravec, J., Keshavjee, S., Khan, A.J., Kulier, R., Leimane, V., Lienhardt, C., Lu, C., Mariandyshev, A., Migliori, G.B., Mirzayev, F., Mitnick, C.D., Nunn, P., Nwagboniwe, G., Oxlade, O., Palmero, D., Pavlinac, P., Quelapio, M.I., Raviglione, M.C., Rich, M.L., Royce, S., Rüsch-Gerdes, S., Salakaia, A., Sarin, R., Sculier, D., Varaine, F., Vitoria, M., Walson, J.L., Wares, F., Weyer, K., White, R.A., Zignol, M.·2011·European Respiratory Journal

Abstract

The production of guidelines for the management of drug-resistant tuberculosis (TB) fits the mandate of the World Health Organization (WHO) to support countries in the reinforcement of patient care. WHO commissioned external reviews to summarise evidence on priority questions regarding case-finding, treatment regimens for multidrug-resistant TB (MDR-TB), monitoring the response to MDR-TB treatment, and models of care. A multidisciplinary expert panel used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to develop recommendations. The recommendations support the wider use of rapid drug susceptibility testing for isoniazid and rifampicin or rifampicin alone using molecular techniques. Monitoring by sputum culture is important for early detection of failure during treatment. Regimens lasting ≥20 months and containing pyrazinamide, a fluoroquinolone, a second-line injectable drug, ethionamide (or prothionamide), and either cycloserine or p-aminosalicylic acid are recommended. The guidelines promote the early use of antiretroviral agents for TB patients with HIV on second-line drug regimens. Systems that primarily employ ambulatory models of care are recommended over others based mainly on hospitalisation. Scientific and medical associations should promote the recommendations among practitioners and public health decision makers involved in MDR-TB care. Controlled trials are needed to improve the quality of existing evidence, particularly on the optimal composition and duration of MDR-TB treatment regimens.

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Metadata

Authors
Falzon, D., Jaramillo, E., Schünemann, H. J., Arentz, M., Bauer, M., Bayona, J., Blanc, L., Caminero, J. A., Daley, C. L., Duncombe, C., Fitzpatrick, C., Gebhard, A., Getahun, H., Henkens, M., Holtz, T. H., Keravec, J., Keshavjee, S., Khan, A. J., Kulier, R., Leimane, V., Lienhardt, C., Lu, C., Mariandyshev, A., Migliori, G. B., Mirzayev, F., Mitnick, C. D., Nunn, P., Nwagboniwe, G., Oxlade, O., Palmero, D., Pavlinac, P., Quelapio, M. I., Raviglione, M. C., Rich, M. L., Royce, S., Rüsch-Gerdes, S., Salakaia, A., Sarin, R., Sculier, D., Varaine, F., Vitoria, M., Walson, J. L., Wares, F., Weyer, K., White, R. A., & Zignol, M.
Venue
European Respiratory Journal
Published
2011-08-02
Volume
38
Issue
3
Pages
516-528
ISSN
  • 0903-1936 (ISSN-L)
  • 1399-3003
OpenAlex
W2135027892
Cited by
1,100
References
7
FWCI
78.88
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: WHO guidelines for the programmatic management of drug-resistant tuberculosis: 2011 update. https://app.cochat.ai/papers/10.1183/09031936.00073611
The paper
Falzon, D., Jaramillo, E., Schünemann, H. J., Arentz, M., Bauer, M., Bayona, J., Blanc, L., Caminero, J. A., Daley, C. L., Duncombe, C., Fitzpatrick, C., Gebhard, A., Getahun, H., Henkens, M., Holtz, T. H., Keravec, J., Keshavjee, S., Khan, A. J., Kulier, R., . . . Zignol, M. (2011). WHO guidelines for the programmatic management of drug-resistant tuberculosis: 2011 update. European Respiratory Journal. https://doi.org/10.1183/09031936.00073611

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.