The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Asthma, airway inflammation and epithelial damage in swimmers and cold-air athletes
Open accessAbstract
Endurance athletes show an increased prevalence of airway hyperresponsiveness. The aim of the present study was to evaluate the long-term effects of training on airway responsiveness, inflammation and epithelial damage in swimmers and cold-air athletes. In total, 64 elite athletes (32 swimmers and 32 cold-air athletes), 32 mild asthmatic subjects and 32 healthy controls underwent allergy skin prick testing, methacholine challenge and induced sputum analysis. Overall, 69% of swimmers and 28% of cold-air athletes had airway hyperresponsiveness. Sputum neutrophil count correlated with the number of training hours per week in both swimmers and cold-air athletes. Eosinophil counts were higher in swimmers than in healthy subjects, although they were lower than in asthmatic subjects, and correlated with airway hyperresponsiveness in swimmers only. The eosinophil count in cold-air athletes was similar to that in healthy subjects. Bronchial epithelial cell count was not correlated with airway hyperresponsiveness but was significantly increased in swimmers, compared with healthy and asthmatic controls. In conclusion, the present authors observed significant airway inflammation only in competitive athletes with airway hyperresponsiveness. However, the majority of elite athletes showed evidence of bronchial epithelial damage that could possibly contribute to the development of airway hyperresponsiveness.
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“In the lung, exposure to chlorination stressors has long been associated with a role in chronic inflammatory diseases of the respiratory system (137, 144–148).”
From Hypochlorous Acid: From Innate Immune Factor and Environmental Toxicant to Chemopreventive Agent Targeting Solar UV-Induced Skin Cancer (2022) · cites this paper as [147]
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Cites
Global strategy for asthma management and prevention: GINA executive summary
Bateman, E. D., Hurd, S. S., Barnes, P. J., Bousquet, J., Drazen, J. M., FitzGerald, M., Gibson, P., Ohta, K., O'Byrne, P., Pedersen, S. E., et al. (2008) · European Respiratory Journal · doi:10.1183/09031936.00138707 · Cited by 3,203
Induced Sputum Cell Counts in Healthy Adults
Belda, J., Leigh, R., PARAMESWARAN, K. N., O’Byrne, P. M., Sears, M. R., & HARGREAVE, F. E. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.2.9903097 · Cited by 390
Karjalainen, E.-M., Laitinen, A., Sue‐Chu, M., Altraja, A., Bjermer, L. H., & Laitinen, L. A. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.6.9907025 · Cited by 319
Bernard, A., Carbonnelle, S., Michel, O., Higuet, S., de Burbure, C., Buchet, J.-P., Hermans, C., Dumont, X., & Doyle, I. (2003) · Occupational and Environmental Medicine · doi:10.1136/oem.60.6.385 · Cited by 256
Airway injury as a mechanism for exercise-induced bronchoconstriction in elite athletes
Anderson, S. D., & Kippelen, P. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.05.001 · Cited by 237
Spontaneous and Induced Sputum to Measure Indices of Airway Inflammation in Asthma
Pizzichini, M. M. M., Popov, T. A., Efthimiadis, A., Hussack, P., Evans, S. W., Pizzichini, E., Dolovich, J., & Hargreave, F. E. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.154.4.8887576 · Cited by 230
Helenius, I., Rytil[auml ], P., Sarna, S., Lumme, A., Helenius, M., Remes, V., & Haahtela, T. (2002) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2002.124769a · Cited by 217
Cold air-provoked respiratory symptoms: the mechanisms and management
Koskela, H. O. (2007) · International Journal of Circumpolar Health · doi:10.3402/ijch.v66i2.18237 · Cited by 213
Structural changes in the airways in asthma: observations and consequences
Bai, T. R., & Knight, D. A. (2005) · Clinical Science · doi:10.1042/cs20040342 · Cited by 182
Aerobic Exercise Attenuates Airway Inflammatory Responses in a Mouse Model of Atopic Asthma
Pastva, A. M., Estell, K., Schoeb, T. R., Atkinson, T. P., & Schwiebert, L. M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.7.4520 · Cited by 160
Airway Hyperresponsiveness in Elite Athletes
Langdeau, J.-B., Turcotte, H., BOWIE, D. M., Jobin, J., DESGAGNÉ, P., & Boulet, L. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.5.9909008 · Cited by 160
Self-citationCHRONIC EFFECTS OF MECHANICAL FORCE ON AIRWAYS
Tschumperlin, D. J., & Drazen, J. M. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.072304.113102 · Cited by 142
Lemière, C., Malo, J.-L., & Boutet, M. (1997) · European Respiratory Journal · doi:10.1183/09031936.97.10010241 · Cited by 140
Sue‐Chu, M., Larsson, L., Moen, T., Rennard, S., & Bjermer, L. (1999) · European Respiratory Journal · doi:10.1183/09031936.99.13362699 · Cited by 137
Carbonnelle, S., Francaux, M., Doyle, I., Dumont, X., Burbure, C. D., Morel, G., Michel, O., & Bernard, A. (2002) · Biomarkers · doi:10.1080/13547500210166612 · Cited by 131
Role of airway epithelial cells in development of asthma and allergic rhinitis
Wang, Y., Bai, C., Li, K., Adler, K. B., & Wang, X. (2008) · Respiratory Medicine · doi:10.1016/j.rmed.2008.01.017 · Cited by 117
Induced sputum to assess airway inflammation: a study of reproducibility
Spanevello, A., Migliori, G. B., Sharara, A. M., BALLARDlNI, L., BRIDGE, P., PISATT, P., Neri, M., & Ind, P. W. (1997) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.1997.tb01150.x · Cited by 115
Chlorination Products: Emerging Links with Allergic Diseases
Bernard, A. (2007) · Current Medicinal Chemistry · doi:10.2174/092986707781058940 · Cited by 108
Increased airway inflammatory cells in endurance athletes: what do they mean?
Bonsignore, M. R., Morici, G., Vignola, A. M., Riccobono, L., Bonanno, A., Profita, M., Abate, P., Scichilone, N., Amato, G. M., Bellia, V., et al. (2003) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2003.01557.x · Cited by 96
Sue‐Chu, M., Karjalainen, E.-M., Laitinen, A., Larsson, L., Laitinen, L. A., & Bjermer, L. H. (2000) · Respiration · doi:10.1159/000029541 · Cited by 91
Epithelium-derived relaxing factor(s) and bronchial reactivity
Vanhoutte, P. M. (1989) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(89)90095-x · Cited by 78
Endurance Training Damages Small Airway Epithelium in Mice
Chimenti, L., Morici, G., Paternò, A., Bonanno, A., Siena, L., Licciardi, A., Veca, M., Guccione, W., Macaluso, F., Bonsignore, G., et al. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200608-1086oc · Cited by 75
Airway epithelium-derived inhibitory factor
Goldie, R. G., Fernandes, L. B., Farmer, S. G., & Hay, D. W. P. (1990) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(90)90320-8 · Cited by 73
No effect of montelukast on asthma‐like symptoms in elite ice hockey players
Helenius, I. J., Lumme, A., Öunap, J., Obase, Y., Rytilä, P. H., Sarna, S. J., Alaranta, A., Remes, V., & Haahtela, T. (2003) · Allergy · doi:10.1046/j.1398-9995.2003.00353.x · Cited by 60
Epithelial shedding is associated with nasal reactions to cold, dry air
Cruz, A. A., Naclerio, R. M., Proud, D., & Togias, A. G. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.01.054 · Cited by 58
Airway inflammation in the elite athlete and type of sport
Belda, J., Ricart, S., Casan, P., Giner, J., Bellido-Casado, J., Torrejon, M., Margarit, G., & Drobnic, F. (2008) · British Journal of Sports Medicine · doi:10.1136/bjsm.2007.036335 · Cited by 52
Airway cooling and mucosal injury during cold weather exercise
Davis, M. S., LOCKARD, A. J., MARLIN, D. J., & Freed, A. N. (2002) · Equine Veterinary Journal · doi:10.1111/j.2042-3306.2002.tb05458.x · Cited by 37
Bronchial epithelial shedding in asthmatics and non-asthmatics
Montefort, S., Roche, W. R., & Holgate, S. T. (1993) · Respiratory Medicine · doi:10.1016/s0954-6111(06)80346-x · Cited by 36
Airway Cell Composition at Rest and after an All-out Test in Competitive Rowers
MORICI, G., Bonsignore, M. R., Zangla, D., Riccobono, L., Profita, M., Bonanno, A., Paternò, A., GIORGI, R. D., Mirabella, F., Chimenti, L., et al. (2004) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000142411.27685.72 · Cited by 34
(2005) · European Respiratory Society eBooks · doi:10.1183/1025448x.erm3305 · Cited by 25
Bronchial hyperresponsiveness in athletes: mechanisms for development
Bjermer, L. H., & Anderson, S. D. (2005) · European Respiratory Society eBooks · doi:10.1183/1025448x.00033-004 · Cited by 14
The role of the environment and climate in relation to outdoor and indoor sports
Drobnic, F., & Haahtela, T. (2005) · European Respiratory Society eBooks · doi:10.1183/1025448x.00033-005 · Cited by 12
Epidemiology of asthma, allergy and bronchial hyperresponsiveness in sports
Haahtela, T., Larsson, K., & Bonini, S. (2005) · European Respiratory Society eBooks · doi:10.1183/1025448x.00033-001 · Cited by 7
Adult cystic fibrosis: Current issues in a regional unit
Webb, A. K., Dodd, M. E., Abbott, J., & Maddison, J. (1993) · Respiratory Medicine · doi:10.1016/s0954-6111(05)80307-5 · Cited by 6
Research works printed but not linked: 1
- 1993, Respir Med, 87, 9
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D’Amato, M., Molino, A., Calabrese, G., Cecchi, L., Annesi‐Maesano, I., & D’Amato, G. (2018) · Clinical and Translational Allergy · doi:10.1186/s13601-018-0208-9 · Cited by 236
“Bronchial biopsies of winter athletes have shown evidence of airway remodelling, possibly due to repeated cold-air and hyperventilation damage to the airways, although more research is needed on this influence on airway function [19, 20].”
BackgroundBergeron, M., Bahr, R., Bärtsch, P., Bourdon, L., Calbet, J. A. L., Carlsen, K. ‐., Castagna, O., González‐Alonso, J., Lundby, C., Maughan, R., et al. (2012) · British Journal of Sports Medicine · doi:10.1136/bjsports-2012-091296 · Cited by 214
Hallstrand, T. S., Leuppi, J. D., Joos, G., Hall, G. L., Carlsen, K., Kaminsky, D. A., Coates, A. L., Cockcroft, D. W., Culver, B. H., Diamant, Z., et al. (2018) · European Respiratory Journal · doi:10.1183/13993003.01033-2018 · Cited by 175
Exercise and asthma: an overview
Giacco, S. R. D., Firinu, D., Bjermer, L. H., & Carlsen, K. (2015) · European Clinical Respiratory Journal · doi:10.3402/ecrj.v2.27984 · Cited by 164
“Other authors (46, 47) reported a correlation between training load and sputum neutrophilia.”
BackgroundRespiratory health of elite athletes – preventing airway injury: a critical review
Kippelen, P., Fitch, K. D., Anderson, S. D., Bougault, V., Boulet, L., Rundell, K. W., Sue‐Chu, M., & McKenzie, D. C. (2012) · British Journal of Sports Medicine · doi:10.1136/bjsports-2012-091056 · Cited by 135
Self-citation
Metadata
- Authors
- Bougault, V., Turmel, J., St-Laurent, J., Bertrand, M., & Boulet, L.-P.
- Affiliations
- Institut universitaire de cardiologie et de pneumologie de Québec (CA)
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2009-01-07
- Volume
- 33
- Issue
- 4
- Pages
- 740-746
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2158216179
- Cited by
- 170
- References
- 34
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 8 · 2023: 4 · 2022: 8 · 2021: 6 · 2020: 6 · 2019: 2 · 2018: 12 · 2017: 8 · 2016: 13 · 2015: 10 · 2014: 11 · 2013: 19 · 2012: 19
- FWCI
- 11.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Respiratory Journal (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory and Cough-Related Research
- Keywords
- airway hyperresponsiveness, asthma, airway inflammation, swimmers, endurance athletes, training, sputum neutrophils, eosinophils, methacholine challenge, induced sputum, bronchial epithelial cells
- MeSH terms
- Adolescent, Adult, Analysis of Variance, Asthma, Bronchial Provocation Tests, Cold Temperature, Female, Humans, Inflammation, Male, Physical Fitness, Regression Analysis, Seasons, Skin Tests, Sports, Sputum, Swimming, Case-Control Studies, Bronchial Hyperreactivity
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