Cited by 168Muscle Physiology and DisordersChronic Obstructive Pulmonary Disease (COPD) ResearchNutrition and Health in Aging

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Peroxisome proliferator-activated receptor expression is reduced in skeletal muscle in COPD

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Remels, A. H., Schrauwen, P., Broekhuizen, R., Willems, J., Kersten, S., Gosker, H. R., Schols, A. M.·2007·European Respiratory Journal

DOI 10.1183/09031936.00144106

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Abstract

Chronic obstructive pulmonary disease (COPD) is a multiorgan systemic disease. The systemic features are skeletal muscle weakness and cachexia, the latter being associated with systemic inflammation. The exact mechanisms underlying skeletal muscle dysfunction in COPD remain obscure. Recent evidence suggests involvement of the peroxisome proliferator-activated receptors (PPARs) and PPAR-γ coactivator (PGC)-1α in regulation of skeletal muscle morphology and metabolism, and mitochondrial transcription factor A (TFAM) has been implicated in the process of mitochondrial biogenesis. The aim of the present exploratory study was, therefore, to compare these factors in the skeletal muscle of nine healthy control subjects and 14 COPD patients stratified by cachexia. PPAR-γ, PPAR-δ and TFAM were measured at the mRNA and protein level by real-time quantitative PCR and Western blotting, respectively. PPAR-α and PGC-1α were meansured at the mRNA level. PPAR-δ and TFAM protein content, as well as PGC-1α mRNA levels, were decreased in the skeletal muscle of COPD patients compared with healthy controls. The cachectic COPD subgroup was further characterised by decreased PPAR-α mRNA expression and decreased TFAM protein and mRNA levels compared with noncachectic COPD patients. In addition, PPAR-α mRNA levels in skeletal muscle correlated negatively with inflammatory markers in plasma. Therefore, a disturbed expression of these regulatory factors may well underlie the disturbed skeletal muscle functioning in chronic obstructive pulmonary disease.

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Authors: Remels, A. H., Schrauwen, P., Broekhuizen, R., Willems, J., Kersten, S., Gosker, H. R., & Schols, A. M.
Affiliations: Maastricht University (NL)
ORCID: Schrauwen, P.
Kersten, S.
Gosker, H. R.
Schols, A. M.
Venue: European Respiratory Journal
Publisher: European Respiratory Society (ERS)
Published: 2007-04-25
Volume: 30
Issue: 2
Pages: 245-252
ISSN: 0903-1936 (ISSN-L)
1399-3003
DOI: 10.1183/09031936.00144106
OpenAlex: W2137507155
Cited by: 168
References: 35
Citations by year: 2026: 2 · 2025: 8 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 4 · 2020: 13 · 2019: 9 · 2018: 8 · 2017: 12 · 2016: 12 · 2015: 6 · 2014: 12 · 2013: 14 · 2012: 10
FWCI: 4.88
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: European Respiratory Journal (publishedVersion)
PubMed (publishedVersion)
Research Publications (Maastricht University) (publishedVersion, other-oa)
Socio-Environmental Systems Modeling (submittedVersion)
Research Publications (Maastricht University) (submittedVersion, other-oa)
Data Archiving and Networked Services (DANS) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Keywords: chronic obstructive pulmonary disease, skeletal muscle, cachexia, PPARγ, PPARδ, PPARα, PGC-1α, TFAM, mitochondrial biogenesis, muscle weakness, systemic inflammation, gene expression
MeSH terms: Aged, Analysis of Variance, Body Composition, DNA-Binding Proteins, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Middle Aged, Phenotype, Respiratory Function Tests, Transcription Factors, Tumor Necrosis Factor-alpha, Blotting, Western, Case-Control Studies, Muscle, Skeletal, Reverse Transcriptase Polymerase Chain Reaction, Mitochondrial Proteins, Pulmonary Disease, Chronic Obstructive, Peroxisome Proliferator-Activated Receptors

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Peroxisome proliferator-activated receptor expression is reduced in skeletal muscle in COPD

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