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Refractory hypertension and sleep apnoea: effect of CPAP on blood pressure and baroreflex

Open access
Logan, A.G., Tkacova, R., Perlikowski, S.M., Leung, R.S., Tisler, A., Floras, J.S., Bradley, T.D.·2003·European Respiratory Journal

Abstract

This study was undertaken to determine whether abolition of obstructive sleep apnoea (OSA) by continuous positive airway pressure (CPAP) could reduce blood pressure (BP) in patients with refractory hypertension. In 11 refractory hypertensive patients with OSA, the acute effects of CPAP on nocturnal BP were studied during sleep and its longer term effects on 24-h ambulatory BP after 2 months. During a single night's application, CPAP abolished OSA and reduced systolic BP in stage 2 sleep from 138.3±6.8 to 126.0±6.3 mmHg. There was also a trend towards a reduction in average diastolic BP (from 77.7±4.5 to 72.9±4.5). CPAP usage for 2 months was accompanied by an 11.0±4.4 mmHg reduction in 24-h systolic BP. In addition, both the nocturnal and daytime components of systolic BP fell significantly by 14.4±4.4 and 9.3±3.9 mmHg, respectively. Diastolic BP was reduced significantly at night by 7.8±3.0 mmHg. In patients with refractory hypertension, acute abolition of obstructive sleep apnoea by continuous positive airway pressure reduces nocturnal blood pressure. These data also suggest that continuous positive airway pressure may reduce nocturnal and daytime systolic blood pressure chronically. Randomised trials are needed to confirm the latter results.

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Metadata

Authors
Logan, A. G., Tkacova, R., Perlikowski, S. M., Leung, R. S., Tisler, A., Floras, J. S., & Bradley, T. D.
Venue
European Respiratory Journal
Published
2003-02
Volume
21
Issue
2
Pages
241-247
ISSN
  • 0903-1936 (ISSN-L)
  • 1399-3003
OpenAlex
W2148891650
Cited by
296
References
8
FWCI
9.59
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Refractory hypertension and sleep apnoea: effect of CPAP on blood pressure and baroreflex. https://app.cochat.ai/papers/10.1183/09031936.03.00035402
The paper
Logan, A. G., Tkacova, R., Perlikowski, S. M., Leung, R. S., Tisler, A., Floras, J. S., & Bradley, T. D. (2003). Refractory hypertension and sleep apnoea: effect of CPAP on blood pressure and baroreflex. European Respiratory Journal. https://doi.org/10.1183/09031936.03.00035402

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.