The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Impact of preventing exacerbations on deterioration of health status in COPD
Open accessAbstract
Exacerbations of chronic obstuctive pulmonary disease (COPD) are associated with worse health status. The Inhaled Steroids in Obstructive Lung Disease in Europe (ISOLDE) study showed that treatment with fluticasone propionate (FP) reduced exacerbation frequency and the rate of deterioration in health status as compared with placebo. The present study analysed these data to test whether the effect of FP on health status was attributable to its effect on exacerbations. Rates of deterioration in St George's Respiratory Questionnaire (SGRQ) total score were obtained for 613 patients with moderate to severe COPD followed for a maximum of 3 yrs. Exacerbation rates were skewed and could not be normalised, therefore, patients were stratified into three exacerbation groups: none, infrequent (<1.65 exacerbations·yr−1) and frequent (>1.65 exacerbations·yr−1). There were 91 patients with no exacerbations, 285 with infrequent exacerbations and 235 with frequent exacerbations. Frequent exacerbations were independently associated with a worse baseline SGRQ score (p<0.0001) and a more rapid rate of deterioration in health status (p=0.0003). Exacerbation frequency and rate of decline in forced expiratory volume in one second were independently related to the rate of deterioration in SGRQ score. Statistical modelling showed the beneficial effect of fluticasone propionate on deterioration in health status to be largely due to its effect on exacerbation frequency.
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Cites
Standards for the Diagnosis and Care of Patients with Chronic Obstructive Pulmonary Disease
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Self-citationEffect of Exacerbation on Quality of Life in Patients with Chronic Obstructive Pulmonary Disease
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Self-citationCalverley, P., Pauwels, R., Vestbo, J., Jones, P., Pride, N., Gulsvik, A., Anderson, J., & Maden, C. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12459-2 · Cited by 1,221
Self-citationTime Course and Recovery of Exacerbations in Patients with Chronic Obstructive Pulmonary Disease
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A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease
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Cited by
Vestbo, J., Hurd, S. S., Agustí, A. G., Jones, P. W., Vogelmeier, C., Anzueto, A., Barnes, P. J., Fabbri, L. M., Martinez, F. J., Nishimura, M., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201204-0596pp · Cited by 15,983
Self-citationRabe, K. F., Hurd, S., Anzueto, A., Barnes, P. J., Buist, S. A., Calverley, P., Fukuchi, Y., Jenkins, C., Rodriguez-Roisin, R., van Weel, C., et al. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200703-456so · Cited by 4,925
Self-citationExacerbations of chronic obstructive pulmonary disease
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Inhaled steroids and risk of pneumonia for chronic obstructive pulmonary disease
Kew, K. M., & Seniukovich, A. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010115.pub2 · Cited by 398
Exacerbation rate, health status and mortality in COPD – a review of potential interventions
Seemungal, T. (2009) · International Journal of Chronic Obstructive Pulmonary Disease · doi:10.2147/copd.s3385 · Cited by 197
Metadata
- Authors
- Spencer, S., Calverley, P. M. A., Burge, P. S., & Jones, P. W.
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2004-05
- Volume
- 23
- Issue
- 5
- Pages
- 698-702
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2154476916
- Cited by
- 441
- References
- 23
- FWCI
- 22.38
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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