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Cited by 137Obstructive Sleep Apnea ResearchTemporomandibular Joint DisordersOrthodontics and Dentofacial Orthopedics

Long-term follow-up after surgical treatment of obstructive sleep apnoea by maxillomandibular advancement

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Conradt, R, Hochban, W, Brandenburg, U, Heitmann, J, Peter, JH·1997·European Respiratory Journal
DOI 10.1183/09031936.97.10010123
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Abstract

Obstructive sleep apnoea (OSA) is a common disorder with potentially serious consequences. If maxillary and mandibular deficiency, often in combination with a narrow posterior airway space is present, therapy of OSA by maxillomandibular osteotomy is possible. However, long-term follow-up of patients undergoing these procedures is lacking. We present the results of 15 OSA patients (1 female and 14 males), who underwent maxillomandibular advancement surgery with a follow-up of at least 2 yrs. Polysomnography was performed before surgery, after 6-12 weeks, and 1 and 2 yrs postoperatively. Mean apnoea/hypopnoea index (AHI) decreased from 51.4 events.h-1 before therapy to 5.0 events.h-1 6 weeks postoperatively, and was 8.5 events.h-1 after 2 yrs. Oxygen saturation significantly increased following surgery. After 2 yrs, the AHI was < 10 events.h-1 in 12 out of 15 subjects. No significant changes were found comparing the 6-12 weeks versus the 2 year follow-up data. The significant increase in stage 3/4 non-rapid eye movement (NREM) sleep and decrease in stage 1 NREM sleep, indicative of the restoration of normal physiological sleep structure, persisted in 14 of the 15 subjects 2 yrs postoperatively. Three patients, however, did not show satisfactory improvement 2 yrs postoperatively; two showed obstructive and one central respiratory events. This study demonstrates that maxillomandibular advancement is successful in a high percentage of patients carefully selected by cephalometric and polysomnographic investigation. Postoperative success has proved to be stable over a period of 2 yrs. Further preoperative evaluation seems necessary in patients with predominantly mixed or central apnoeas.

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Authors
Conradt, R., Hochban, W., Brandenburg, U., Heitmann, J., & Peter, J.
Affiliations
Philipps University of Marburg (DE)
ORCID
Venue
European Respiratory Journal
Publisher
European Respiratory Society (ERS)
Published
1997-01-01
Volume
10
Issue
1
Pages
123-128
ISSN
  • 0903-1936 (ISSN-L)
  • 1399-3003
DOI
10.1183/09031936.97.10010123
OpenAlex
W2104173058
Cited by
137
References
27
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 3 · 2021: 6 · 2020: 4 · 2019: 4 · 2018: 1 · 2017: 3 · 2016: 5 · 2015: 6 · 2014: 10 · 2013: 9 · 2012: 7
FWCI
2.24
Type
journal article
Language
en
Open access
Locations
  • European Respiratory Journal (publishedVersion)
  • PubMed (publishedVersion)
Funders
Deutsche Forschungsgemeinschaft
Topics
  • Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
  • Health Sciences › Health Professions › Complementary and Manual Therapy › Temporomandibular Joint Disorders
  • Health Sciences › Dentistry › Orthodontics › Orthodontics and Dentofacial Orthopedics
Keywords
obstructive sleep apnea, maxillomandibular advancement, long-term follow-up, apnea-hypopnea index, oxygen saturation, sleep architecture, NREM sleep stages, central sleep apnea, patient selection for surgery, cephalometric analysis
MeSH terms
Adult, Analysis of Variance, Apnea, Cephalometry, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Mandible, Maxilla, Osteotomy, Oxygen Consumption, Sleep Apnea Syndromes, Sleep Stages, Sleep, REM, Treatment Outcome, Polysomnography, Osteotomy, Le Fort

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