The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives
Open accessAbstract
Clinical and translational research has played a major role in advancing our understanding of pulmonary hypertension (PH), including pulmonary arterial hypertension and other forms of PH with severe vascular remodelling (e.g. chronic thromboembolic PH and pulmonary veno-occlusive disease). However, PH remains an incurable condition with a high mortality rate, underscoring the need for a better transfer of novel scientific knowledge into healthcare interventions. Herein, we review recent findings in pathology (with the questioning of the strict morphological categorisation of various forms of PH into pre- or post-capillary involvement of pulmonary vessels) and cellular mechanisms contributing to the onset and progression of pulmonary vascular remodelling associated with various forms of PH. We also discuss ways to improve management and to support and optimise drug development in this research field.
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Paulin, R., Dromparis, P., Sutendra, G., Gurtu, V., Zervopoulos, S., Bowers, L., Haromy, A., Webster, L., Provencher, S., Bonnet, S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.08.011 · Cited by 214
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Cited by
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Sotatercept for the Treatment of Pulmonary Arterial Hypertension
Humbert, M., McLaughlin, V., Gibbs, J. S. R., Gomberg-Maitland, M., Hoeper, M. M., Preston, I. R., Souza, R., Waxman, A., Escribano Subias, P., Feldman, J., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2024277 · Cited by 608
Self-citationHansmann, G., Koestenberger, M., Alastalo, T.-P., Apitz, C., Austin, E. D., Bonnet, D., Budts, W., D'Alto, M., Gatzoulis, M. A., Hasan, B. S., et al. (2019) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2019.06.022 · Cited by 444
Hypoxia-inducible factor signaling in pulmonary hypertension
Pullamsetti, S. S., Mamazhakypov, A., Weissmann, N., Seeger, W., & Savai, R. (2020) · Journal of Clinical Investigation · doi:10.1172/jci137558 · Cited by 234
Self-citationObesity, estrogens and adipose tissue dysfunction - implications for pulmonary arterial hypertension
Mair, K. M., Gaw, R., & MacLean, M. R. (2020) · Pulmonary Circulation · doi:10.1177/2045894020952023 · Cited by 129
Metadata
- Authors
- Humbert, M., Guignabert, C., Bonnet, S., Dorfmüller, P., Klinger, J. R., Nicolls, M. R., Olschewski, A. J., Pullamsetti, S. S., Schermuly, R. T., Stenmark, K. R., & Rabinovitch, M.
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2019-01
- Volume
- 53
- Issue
- 1
- Pages
- 1801887
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2905582258
- Cited by
- 1,281
- References
- 1
- FWCI
- 72.54
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Humbert, M., Guignabert, C., Bonnet, S., Dorfmüller, P., Klinger, J. R., Nicolls, M. R., Olschewski, A. J., Pullamsetti, S. S., Schermuly, R. T., Stenmark, K. R., & Rabinovitch, M. (2019). Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives. European Respiratory Journal. https://doi.org/10.1183/13993003.01887-2018
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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