Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans

Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes

Petersen, K. F., Dufour, S., Befroy, D., Garcia, R., & Shulman, G. I. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031314 · Cited by 2,193 · see citing works

Heart-Lung Transplantation

Yarbrough, W. M., Robbins, R. C., & Mallidi, H. R. (2016) · CRC Press eBooks · doi:10.3109/9781439802571-25 · Cited by 2,161 · see citing works

Regulation of cellular metabolism by protein lysine acetylation

Zhao, S., Xu, W., Jiang, W., Yu, W., Lin, Y., Zhang, T., Yao, J., Zhou, L., Zeng, Y., Li, H., et al. (2010) · Science · doi:10.1126/science.1179689 · Cited by 1,910 · see citing works

A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth

Bonnet, S., Archer, S. L., Allalunis‐Turner, J., Haromy, A., Beaulieu, C., Thompson, R. B., Lee, C. T., Lopaschuk, G. D., Puttagunta, L., Bonnet, S. B., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.10.020 · Cited by 1,530 · see citing works

Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

Michishita, E., Park, J. Y., Burneskis, J. M., Barrett, J. C., & Horikawa, I. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-01-0033 · Cited by 1,364 · see citing works

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

Ahn, B.-H., Kim, H.-S., Song, S., Lee, I. H., Liu, J., Vassilopoulos, A., Deng, C.-X., & Finkel, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803790105 · Cited by 1,291 · see citing works

Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

Lombard, D. B., Alt, F. W., Cheng, H.-L., Bunkenborg, J., Streeper, R. S., Mostoslavsky, R., Kim, J., Yancopoulos, G., Valenzuela, D., Murphy, A., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01636-07 · Cited by 1,216 · see citing works

Mitochondrial Dynamics — Mitochondrial Fission and Fusion in Human Diseases

Archer, S. L. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1215233 · Cited by 1,103 · see citing works

Mitochondrial Membrane Potential in Living Cells

Chen, L. B. (1988) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.04.110188.001103 · Cited by 1,039 · see citing works

SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome

Hirschey, M. D., Shimazu, T., Jing, E., Grueter, C. A., Collins, A. M., Aouizerat, B., Stančáková, A., Goetzman, E., Lam, M. M., Schwer, B., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.07.019 · Cited by 787 · see citing works

SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress

Kim, H.-S., Patel, K., Muldoon-Jacobs, K., Bisht, K. S., Aykin-Burns, N., Pennington, J. D., van der Meer, R., Nguyen, P., Savage, J., Owens, K. M., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.11.023 · Cited by 785 · see citing works

SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization

Finley, L. W. S., Carracedo, A., Lee, J., Souza, A., Egia, A., Zhang, J., Teruya-Feldstein, J., Moreira, P. I., Cardoso, S. M., Clish, C. B., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.02.014 · Cited by 782 · see citing works

Partners in transcription: NFAT and AP-1

Macián, F., López‐Rodríguez, C., & Rao, A. (2001) · Oncogene · doi:10.1038/sj.onc.1204386 · Cited by 766 · see citing works

Metabolic Modulation of Glioblastoma with Dichloroacetate

Michelakis, E. D., Sutendra, G., Dromparis, P., Webster, L., Haromy, A., Niven, E. B., Maguire, C., Gammer, T.-L., Mackey, J. R., Fulton, D. S., et al. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3000677 · Cited by 722 · see citing works

An Abnormal Mitochondrial–Hypoxia Inducible Factor-1α–Kv Channel Pathway Disrupts Oxygen Sensing and Triggers Pulmonary Arterial Hypertension in Fawn Hooded Rats

Bonnet, S., Michelakis, E. D., Porter, C. J., Andrade-Navarro, M. A., Thébaud, B., Bonnet, S. B., Haromy, A., Harry, G., Moudgil, R., McMurtry, M. S., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.609008 · Cited by 589 · see citing works

Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5

Schlicker, C., Gertz, M., Papatheodorou, P., Kachholz, B., Becker, C. F. W., & Steegborn, C. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.07.048 · Cited by 531 · see citing works

Disruption of the Ang II type 1 receptor promotes longevity in mice

Benigni, A., Corna, D., Zoja, C., Sonzogni, A., Latini, R., Salio, M., Conti, S., Rottoli, D., Longaretti, L., Cassis, P., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36703 · Cited by 486 · see citing works

Dynamin-Related Protein 1–Mediated Mitochondrial Mitotic Fission Permits Hyperproliferation of Vascular Smooth Muscle Cells and Offers a Novel Therapeutic Target in Pulmonary Hypertension

Marsboom, G., Tóth, P. T., Ryan, J. J., Hong, Z., Wu, X., Fang, Y.-H., Thenappan, T., Piao, L. H., Zhang, H. J., Pogoriler, J. E., et al. (2012) · Circulation Research · doi:10.1161/circresaha.111.263848 · Cited by 457 · see citing works

SIRT3 Deacetylates and Activates OPA1 To Regulate Mitochondrial Dynamics during Stress

Samant, S. A., Zhang, H. J., Hong, Z., Pillai, V. B., Sundaresan, N. R., Wolfgeher, D., Archer, S. L., Chan, D. C., & Gupta, M. P. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01483-13 · Cited by 446 · see citing works

Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM

Simoneau, J.-A., & Kelley, D. E. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.83.1.166 · Cited by 441 · see citing works

Molecular identification of the role of voltage-gated K+ channels, Kv1.5 and Kv2.1, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes.

Archer, S. L., Souil, E., Dinh‐Xuan, A. T., Schremmer, B., Mercier, J., Yaagoubi, A. E., Nguyen-Huu, L., Reeve, H. L., & Hampl, V. (1998) · Journal of Clinical Investigation · doi:10.1172/jci333 · Cited by 403 · see citing works

Activation of Glycogen Synthase Kinase 3β Disrupts the Binding of Hexokinase II to Mitochondria by Phosphorylating Voltage-Dependent Anion Channel and Potentiates Chemotherapy-Induced Cytotoxicity

Pastorino, J. G., Hoek, J. B., & Shulga, N. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1925 · Cited by 398 · see citing works

Alterations of cellular bioenergetics in pulmonary artery endothelial cells

Xu, W., Koeck, T., Lara, A., Neumann, D. R., DiFilippo, F. P., Koo, M., Janocha, A. J., Masri, F. A., Arroliga, A. C., Jennings, C. A., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605080104 · Cited by 390 · see citing works

Pulmonary Arterial Hypertension Is Linked to Insulin Resistance and Reversed by Peroxisome Proliferator–Activated Receptor-γ Activation

Hansmann, G., Wagner, R. A., Schellong, S., Pérez, V. D. J., Urashima, T., Wang, L., Sheikh, A. Y., Suen, R. S., Stewart, D. J., & Rabinovitch, M. (2007) · Circulation · doi:10.1161/circulationaha.106.663120 · Cited by 367 · see citing works

Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1α-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer

Archer, S. L., Gomberg‐Maitland, M., Maitland, M. L., Rich, S., Garcia, J. G. N., & Weir, Ε. K. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01324.2007 · Cited by 366 · see citing works

Succinate Dehydrogenase Is a Direct Target of Sirtuin 3 Deacetylase Activity

Finley, L. W. S., Haas, W., Desquiret‐Dumas, V., Wallace, D. C., Procaccio, V., Gygi, S. P., & Haigis, M. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023295 · Cited by 364 · see citing works

The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted

Bonnet, S., Rochefort, G. Y., Sutendra, G., Archer, S. L., Haromy, A., Webster, L., Hashimoto, K., Bonnet, S. N., & Michelakis, E. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610467104 · Cited by 363 · see citing works

Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension

McMurtry, M. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23203 · Cited by 362 · see citing works

Cell-Permeating <i>α</i> -Ketoglutarate Derivatives Alleviate Pseudohypoxia in Succinate Dehydrogenase-Deficient Cells

MacKenzie, E. D., Selak, M. A., Tennant, D. A., Payne, L. J., Crosby, S., Frederiksen, C. M., Watson, D. G., & Gottlieb, E. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01927-06 · Cited by 359 · see citing works

Diversity in Mitochondrial Function Explains Differences in Vascular Oxygen Sensing

Michelakis, E. D., Hampl, V., Nsair, A., Wu, X., Harry, G., Haromy, A., Gurtu, R., & Archer, S. L. (2002) · Circulation Research · doi:10.1161/01.res.0000024689.07590.c2 · Cited by 309 · see citing works

Attenuated K+ channel gene transcription in primary pulmonary hypertension

Yuan, X. J., Wang, J., Juhaszova, M., Gaine, S., & Rubin, L. J. (1998) · The Lancet · doi:10.1016/s0140-6736(05)78495-6 · Cited by 297 · see citing works

Complex I Binding by a Virally Encoded RNA Regulates Mitochondria-Induced Cell Death

Reeves, M., Davies, A., Mcsharry, B. P., Wilkinson, G., & Sinclair, J. (2007) · Science · doi:10.1126/science.1142984 · Cited by 297 · see citing works

Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation

Jing, E., O’Neill, B. T., Rardin, M. J., Kleinridders, A., Ilkeyeva, O. R., Ussar, S., Bain, J. R., Lee, K. Y., Verdin, E. M., Newgard, C. B., et al. (2013) · Diabetes · doi:10.2337/db12-1650 · Cited by 283 · see citing works

Insulin resistance in pulmonary arterial hypertension

Zamanian, R. T., Hansmann, G., Snook, S., Lilienfeld, D. E., Rappaport, K., Reaven, G. M., Rabinovitch, M., & Doyle, R. L. (2008) · European Respiratory Journal · doi:10.1183/09031936.00000508 · Cited by 274 · see citing works

The Metabolic Basis of Pulmonary Arterial Hypertension

Sutendra, G., & Michelakis, E. D. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.01.004 · Cited by 269 · see citing works

Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology

Sutendra, G., & Michelakis, E. D. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00038 · Cited by 263 · see citing works

Mitochondrial sirtuins: regulators of protein acylation and metabolism

He, W., Newman, J. C., Wang, M. Z., Ho, L., & Verdin, E. (2012) · Trends in Endocrinology &amp; Metabolism · doi:10.1016/j.tem.2012.07.004 · Cited by 262 · see citing works

Peroxisome Proliferator-activated Receptor-γ Coactivator-1α Controls Transcription of the Sirt3 Gene, an Essential Component of the Thermogenic Brown Adipocyte Phenotype

Giralt, A., Hondares, E., Villena, J. A., Ribas, F., Díaz-Delfín, J., Giralt, M., Iglesias, R., & Villarroya, F. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.202390 · Cited by 210 · see citing works

Angiotensin converting enzyme expression is increased in small pulmonary arteries of rats with hypoxia-induced pulmonary hypertension.

Morrell, N. W., Atochina‐Vasserman, E. N., Morris, K. G., Danilov, S. M., & Stenmark, K. R. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118228 · Cited by 208 · see citing works

PGC1α-mediated Mitofusin-2 Deficiency in Female Rats and Humans with Pulmonary Arterial Hypertension

Ryan, J. J., Marsboom, G., Fang, Y.-H., Tóth, P. T., Morrow, E., Luo, N., Piao, L. H., Hong, Z., Ericson, K. J., Zhang, H. J., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201209-1687oc · Cited by 194 · see citing works

Mitochondrial activation by inhibition of PDKII suppresses HIF1a signaling and angiogenesis in cancer

Sutendra, G., Dromparis, P., Kinnaird, A. S., Stenson, T. H., Haromy, A., Parker, J. M. R., McMurtry, M. S., & Michelakis, E. D. (2012) · Oncogene · doi:10.1038/onc.2012.198 · Cited by 185 · see citing works

Signal Transducers and Activators of Transcription-3/Pim1 Axis Plays a Critical Role in the Pathogenesis of Human Pulmonary Arterial Hypertension

Paulin, R., Courboulin, A., Meloche, J., Mainguy, V., de la Roque, E. D., Saksouk, N., Côté, J., Provencher, S., Sussman, M. A., & Bonnet, S. (2011) · Circulation · doi:10.1161/circulationaha.110.963314 · Cited by 169 · see citing works

Unrecognized glucose intolerance is common in pulmonary arterial hypertension

Pugh, M. E., Robbins, I. M., Rice, T. W., West, J. D., Newman, J. H., & Hemnes, A. R. (2011) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2011.02.016 · Cited by 154 · see citing works

SIRT3 is Pro-Apoptotic and Participates in Distinct Basal Apoptotic Pathways

Allison, S. J., & Milner, J. (2007) · Cell Cycle · doi:10.4161/cc.6.21.4866 · Cited by 147 · see citing works

Uncoupling Protein 2 Deficiency Mimics the Effects of Hypoxia and Endoplasmic Reticulum Stress on Mitochondria and Triggers Pseudohypoxic Pulmonary Vascular Remodeling and Pulmonary Hypertension

Dromparis, P., Paulin, R., Sutendra, G., Qi, A. C., Bonnet, S., & Michelakis, E. D. (2013) · Circulation Research · doi:10.1161/circresaha.112.300699 · Cited by 143 · see citing works

Heterogeneity in Lung 18 FDG Uptake in Pulmonary Arterial Hypertension

Zhao, L., Ashek, A., Wang, L., Fang, W., Dabral, S., Dubois, O., Cupitt, J., Pullamsetti, S. S., Cotroneo, E., Jones, H. A., et al. (2013) · Circulation · doi:10.1161/circulationaha.113.004136 · Cited by 140 · see citing works

Strain differences in the development of hypertension and glomerular lesions induced by deoxycorticosterone acetate salt in mice

Hartner, A. (2003) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfg299 · Cited by 138 · see citing works

Krüppel-like Factor 5 contributes to pulmonary artery smooth muscle proliferation and resistance to apoptosis in human pulmonary arterial hypertension

Courboulin, A., Tremblay, V. L., Barrier, M., Meloche, J., Jacob, M., Chapolard, M., Bisserier, M., Paulin, R., Lambert, C., Provencher, S., et al. (2011) · Respiratory Research · doi:10.1186/1465-9921-12-128 · Cited by 124 · see citing works

A potential role for insulin resistance in experimental pulmonary hypertension

West, J. D., Niswender, K. D., Johnson, J. A., Pugh, M. E., Gleaves, L. A., Fessel, J. P., & Hemnes, A. R. (2012) · European Respiratory Journal · doi:10.1183/09031936.00030312 · Cited by 123 · see citing works

Genome-wide association analysis identifies a susceptibility locus for pulmonary arterial hypertension

Germain, M., Eyries, M., Montani, D., Poirier, O., Girerd, B., Dorfmüller, P., Coulet, F., Nadaud, S., Maugenre, S., Guignabert, C., et al. (2013) · Nature Genetics · doi:10.1038/ng.2581 · Cited by 103 · see citing works

Characterization of a bidirectional promoter shared between two human genes related to aging: SIRT3 and PSMD13

Bellizzi, D., Dato, S., Cavalcante, P., Covello, G., Cianni, F. D., Passarino, G., Rose, G., & BENEDICTIS, G. D. (2006) · Genomics · doi:10.1016/j.ygeno.2006.09.004 · Cited by 87 · see citing works

Metabolic Adaptations of Three Inbred Strains of Mice (C57BL/6, DBA/2, and 129T2) in Response to a High-Fat Diet

Funkat, A., Massa, C. M., Jovanovska, V., Proietto, J., & Andrikopoulos, S. (2004) · Journal of Nutrition · doi:10.1093/jn/134.12.3264 · Cited by 85 · see citing works

Blood Pressure, Cardiac, and Renal Responses to Salt and Deoxycorticosterone Acetate in Mice

Wang, Q., Hümmler, E., Nussberger, J., Clément, S., Gabbiani, G., Brunner, H. R., & Burnier, M. (2002) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000017902.77985.84 · Cited by 78 · see citing works

Enhanced colon tumor induction in uncoupling protein-2 deficient mice is associated with NF-κB activation and oxidative stress

Derdák, Z., Fülöp, P., Sabo, E., Tavares, R., Berthiaume, E. P., Resnick, M. B., Paragh, G., Wands, J. R., & Baffy, G. (2006) · Carcinogenesis · doi:10.1093/carcin/bgi335 · Cited by 75 · see citing works

Different mechanisms for changes in glucose uptake of the right and left ventricular myocardium in pulmonary hypertension.

Kluge, R., Barthel, H., Pankau, H., Seese, A., Schauer, J., Wirtz, H., Seyfarth, H.-J., Steinbach, J., Sabri, O., & Winkler, J. (2005) · PubMed · Cited by 53 · see citing works

Differential Regulation of Hypoxia-Inducible Factor-1 through Receptor Tyrosine Kinase Transactivation in Vascular Smooth Muscle Cells

Lauzier, M.-C., Pagé, E. L., Michaud, M. D., & Richard, D. E. (2007) · Endocrinology · doi:10.1210/en.2007-0285 · Cited by 47 · see citing works

Uncoupling Protein 2 Promoter Polymorphism −866G/A, Central Adiposity, and Metabolic Syndrome in Asians

Shen, H., Qi, L., Tai, E. S., Chew, S. K., Tan, C. E., & Ordovás, J. M. (2006) · Obesity · doi:10.1038/oby.2006.74 · Cited by 47 · see citing works

Unrecognized Glucose Intolerance Is Common In Pulmonary Arterial Hypertension

Pugh, M. E., Hemnes, A. R., Robbins, I. M., Rice, T. W., & Newman, J. H. (2010) · doi:10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4813 · Cited by 34 · see citing works

Sirtuin 3 Deficiency Does Not Augment Hypoxia-Induced Pulmonary Hypertension

Waypa, G. B., Osborne, S. W., Marks, J. D., Berkelhamer, S. K., Kondapalli, J., & Schumacker, P. T. (2013) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2013-0191oc · Cited by 30 · see citing works

PGC-1αInduction in Pulmonary Arterial Hypertension

Mata, M., Sarrión, I., Milián, L., Juan, G., Ramón, M., Naufal, D., Gil, J. L. S., Ridocci, F., Fabregat‐Andrés, Ó., & Cortijo, J. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/236572 · Cited by 30 · see citing works

Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives

Humbert, M. J. C., Guignabert, C., Bonnet, S., Dorfmüller, P., Klinger, J. R., Nicolls, M. R., Olschewski, A., Pullamsetti, S. S., SCHERMULY, R. T., Stenmark, K. R., et al. (2018) · European Respiratory Journal · doi:10.1183/13993003.01887-2018 · Cited by 1,282 · see citing works

Mitochondria in health, disease, and aging

Harrington, J. S., Ryter, S. W., Plataki, M. E., Price, D. R., & Choi, A. M. K. (2023) · Physiological Reviews · doi:10.1152/physrev.00058.2021 · Cited by 622 · see citing works

Sirtuins and NAD + in the Development and Treatment of Metabolic and Cardiovascular Diseases

Kane, A. E., & Sinclair, D. A. (2018) · Circulation Research · doi:10.1161/circresaha.118.312498 · Cited by 490 · see citing works

Protective effects of sirtuins in cardiovascular diseases: from bench to bedside

Winnik, S. H., Auwerx, J. H., Sinclair, D. A., & Matter, C. M. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv290 · Cited by 443 · see citing works

Metabolic control of epigenetics in cancer

Kinnaird, A. S., Zhao, S., Wellen, K. E., & Michelakis, E. D. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.82 · Cited by 419 · see citing works

SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection

D’Onofrio, N., Servillo, L., & Balestrieri, M. L. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7178 · Cited by 389 · see citing works

SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin

Pi, H., Xu, S., Reiter, R. J., Guo, P., Zhang, L., Li, Y., Li, M., Cao, Z., Tian, L., Xie, J., et al. (2015) · Autophagy · doi:10.1080/15548627.2015.1052208 · Cited by 363 · see citing works

The Mitochondrial Acylome Emerges: Proteomics, Regulation by Sirtuins, and Metabolic and Disease Implications

Carrico, C., Meyer, J. G., He, W., Gibson, B. W., & Verdin, E. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.01.016 · Cited by 331 · see citing works

Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients

Michelakis, E. D., Gurtu, V., Webster, L., Barnes, G. D., Watson, G., Howard, L., Cupitt, J., Paterson, D. I., Thompson, R. B., Chow, K., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aao4583 · Cited by 318 · see citing works

DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway

Bai, J., Cervantes, C., Liu, J., He, S., Zhou, H., Zhang, B., Cai, H., Yin, D., Hu, D., Li, Z., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1708744114 · Cited by 313 · see citing works

Function of the SIRT 3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease

Ansari, A., Rahman, M. S., Saha, S. K., Saikot, F. K., Deep, A., & Kim, K. (2016) · Aging Cell · doi:10.1111/acel.12538 · Cited by 307 · see citing works

SIRT3-AMP-activated protein kinase activation by nitrite and metformin improves hyperglycemia and normalizes pulmonary hypertension associated with heart failure with preserved ejection fraction

Lai, Y.-C., Tabima, D. M., Dube, J. J., Hughan, K. S., Vanderpool, R. R., Goncharov, D. A., St. Croix, C. M., Garcia-Ocaña, A., Goncharova, E. A., Tofovic, S. P., et al. (2016) · Circulation · doi:10.1161/circulationaha.115.018935 · Cited by 270 · see citing works

Lysine acetyltransferases and lysine deacetylases as targets for cardiovascular disease

Li, P., Ge, J., & Li, H. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0235-9 · Cited by 269 · see citing works

Sirtuins, Cell Senescence, and Vascular Aging

Kida, Y., & Goligorsky, M. S. (2015) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2015.11.022 · Cited by 255 · see citing works

Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through a MicroRNA-124/PTBP1 (Polypyrimidine Tract Binding Protein 1)/Pyruvate Kinase Muscle Axis

Zhang, H., Wang, D., Li, M., Plecitá‐Hlavatá, L., D’Alessandro, A., Tauber, J. A., Riddle, S. R., Kumar, S., Flockton, A. R., McKeon, B. A., et al. (2017) · Circulation · doi:10.1161/circulationaha.117.028069 · Cited by 252 · see citing works

Targeting Vascular Remodeling to Treat Pulmonary Arterial Hypertension

Thompson, A. A. R., & Lawrie, A. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.11.005 · Cited by 243 · see citing works

Hypoxia-inducible factor signaling in pulmonary hypertension

Pullamsetti, S. S., Mamazhakypov, A., Weissmann, N., Seeger, W., & Savai, R. (2020) · Journal of Clinical Investigation · doi:10.1172/jci137558 · Cited by 234 · see citing works

The Latest in Animal Models of Pulmonary Hypertension and Right Ventricular Failure

Boucherat, O., Agrawal, V., Lawrie, A., & Bonnet, S. (2022) · Circulation Research · doi:10.1161/circresaha.121.319971 · Cited by 202 · see citing works

Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice

Pillai, V. B., Kanwal, A., Fang, Y. H., Sharp, W. W., Samant, S. A., Arbiser, J. L., & Gupta, M. P. (2017) · Oncotarget · doi:10.18632/oncotarget.16133 · Cited by 194 · see citing works

The sirtuin family members SIRT1, SIRT3 and SIRT6: Their role in vascular biology and atherogenesis

Sosnowska, B., Mazidi, M., Penson, P. E., Gluba-Brzózka, A., Rysz, J., & Banach, M. (2017) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2017.08.027 · Cited by 185 · see citing works

Sirt3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions

Kim, T. S., Jin, Y. B., Kim, Y. S., Kim, S., Kim, J. K., Lee, H.-M., Suh, H.-W., Choe, J. H., Kim, Y. J., Koo, B.-S., et al. (2019) · Autophagy · doi:10.1080/15548627.2019.1582743 · Cited by 172 · see citing works

The role of mitochondrial sirtuins in health and disease

Osborne, B., Bentley, N. L., Montgomery, M. K., & Turner, N. A. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.04.197 · Cited by 179 · see citing works

Mitochondrial metabolism in pulmonary hypertension: beyond mountains there are mountains

Culley, M. K., & Chan, S. Y. (2018) · Journal of Clinical Investigation · doi:10.1172/jci120847 · Cited by 178 · see citing works

SIRT3: A New Regulator of Cardiovascular Diseases

Sun, W., Liu, C., Chen, Q., Liu, N., Yan, Y., & Liu, B. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/7293861 · Cited by 170 · see citing works

Current and future treatments of pulmonary arterial hypertension

Sommer, N., Ghofrani, H. A., Pak, O., Bonnet, S., Provencher, S., Sitbon, O., Rosenkranz, S., Hoeper, M. M., & Kiely, D. G. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15016 · Cited by 165 · see citing works

Cellular Metabolism in Lung Health and Disease

Liu, G., & Summer, R. (2019) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020518-114640 · Cited by 157 · see citing works

Mitochondrial contributions to vascular endothelial dysfunction, arterial stiffness, and cardiovascular diseases

Kirkman, D. L., Robinson, A. T., Rossman, M. J., Seals, D. R., & Edwards, D. G. (2021) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00917.2020 · Cited by 146 · see citing works

Translating Research into Improved Patient Care in Pulmonary Arterial Hypertension

Bonnet, S., Provencher, S., Guignabert, C., Perros, F., Boucherat, O., SCHERMULY, R. T., Hassoun, P. M., Rabinovitch, M., Nicolls, M. R., & Humbert, M. J. C. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201607-1515pp · Cited by 134 · see citing works

BMPR2 Mutation and Metabolic Reprogramming in Pulmonary Arterial Hypertension

Cuthbertson, I., Morrell, N. W., & Caruso, P. L. (2023) · Circulation Research · doi:10.1161/circresaha.122.321554 · Cited by 129 · see citing works

The Role of Mitochondrial DNA in Mediating Alveolar Epithelial Cell Apoptosis and Pulmonary Fibrosis

Kim, S.-J., Cheresh, P., Jablonski, R. P., Williams, D. B., & Kamp, D. W. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160921486 · Cited by 121 · see citing works

Metabolic Profiling of Right Ventricular-Pulmonary Vascular Function Reveals Circulating Biomarkers of Pulmonary Hypertension

Lewis, G. D., Ngo, D., Hemnes, A. R., Farrell, L. A., Domos, C., Pappagianopoulos, P. P., Dhakal, B. P., Souza, A., Shi, X. D., Pugh, M. E., et al. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.10.072 · Cited by 123 · see citing works

Diagnosis, Treatment, and Clinical Management of Pulmonary Arterial Hypertension in the Contemporary Era

Maron, B. A., & Galiè, N. (2016) · JAMA Cardiology · doi:10.1001/jamacardio.2016.4471 · Cited by 124 · see citing works

Emerging role of SIRT3 in endothelial metabolism, angiogenesis, and cardiovascular disease

He, X., Zeng, H., & Chen, J. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27200 · Cited by 121 · see citing works

Mechanisms and treatment of pulmonary arterial hypertension

Ghofrani, H. A., Gomberg‐Maitland, M., Zhao, L., & Grimminger, F. (2024) · Nature Reviews Cardiology · doi:10.1038/s41569-024-01064-4 · Cited by 134 · see citing works

Targeting histone acetylation in pulmonary hypertension and right ventricular hypertrophy

Chelladurai, P., Boucherat, O., Stenmark, K. R., Kracht, M., Seeger, W., Bauer, U., Bonnet, S., & Pullamsetti, S. S. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14932 · Cited by 116 · see citing works

Mitochondria Related Cell Death Modalities and Disease

Tian, C., Liu, Y., Li, Z., Zhu, P., & Zhao, M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.832356 · Cited by 113 · see citing works

Hallmarks of Pulmonary Hypertension: Mesenchymal and Inflammatory Cell Metabolic Reprogramming

D’Alessandro, A., Kasmi, K. C. E., Plecitá‐Hlavatá, L., Ježek, P., Li, M., Zhang, H., Gupte, S. A., & Stenmark, K. R. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7217 · Cited by 110 · see citing works

Sirtuins in vascular diseases: Emerging roles and therapeutic potential

D’Onofrio, N., Vitiello, M., Casale, R., Servillo, L., Giovane, A., & Balestrieri, M. L. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.03.001 · Cited by 104 · see citing works

DNA Damage and Pulmonary Hypertension

Ranchoux, B., Meloche, J., Paulin, R., Boucherat, O., Provencher, S., & Bonnet, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060990 · Cited by 105 · see citing works

Metabolic dysfunction in pulmonary hypertension: from basic science to clinical practice

Chan, S. Y., & Rubin, L. J. (2017) · European Respiratory Review · doi:10.1183/16000617.0094-2017 · Cited by 97 · see citing works

Selenoprotein P Promotes the Development of Pulmonary Arterial Hypertension

Kikuchi, N., Satoh, K., Kurosawa, R., Yaoita, N., Al-Mamun, M. E., Siddique, M. A. H., Omura, J., Satoh, T., Nogi, M., Sunamura, S., et al. (2018) · Circulation · doi:10.1161/circulationaha.117.033113 · Cited by 95 · see citing works

The Role of Pathological Aging in Cardiac and Pulmonary Fibrosis

Murtha, L. A., Morten, M., Schuliga, M. J., Mabotuwana, N. S., Hardy, S. A., Waters, D. W., Burgess, J. K., Ngo, D. T. M., Sverdlov, A. L., Knight, D. A., et al. (2018) · Aging and Disease · doi:10.14336/ad.2018.0601 · Cited by 96 · see citing works

Dysfunctional BMPR2 signaling drives an abnormal endothelial requirement for glutamine in pulmonary arterial hypertension

Egnatchik, R. A., Brittain, E. L., Shah, A. T., Fares, W. H., Ford, H. J., Monahan, K., Kang, C., Kocurek, E. G., Shijun, Z., Luong, T., et al. (2016) · Pulmonary Circulation · doi:10.1086/690236 · Cited by 92 · see citing works

Vascular aging: Molecular mechanisms and potential treatments for vascular rejuvenation

Mistriotis, P., & Andreadis, S. T. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.05.006 · Cited by 88 · see citing works

Mitochondrial Sirtuins in cardiometabolic diseases

Tang, X., Chen, X., Chen, H., & Liu, D. (2017) · Clinical Science · doi:10.1042/cs20160685 · Cited by 87 · see citing works

Suppression of Endothelial-to-Mesenchymal Transition by SIRT (Sirtuin) 3 Alleviated the Development of Hypertensive Renal Injury

Lin, J., Zheng, Y., Zhang, Z.-B., Shen, W., Li, X., Wei, T., Ruan, C., Chen, X.-H., Zhu, D., & Gao, P. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.10482 · Cited by 85 · see citing works

A systematic review of genetic mutations in pulmonary arterial hypertension

García‐Rivas, G., Carlos Jerjes-Sánchez, D., Rodríguez, D., Garcia‐Pelaez, J., & Treviño, V. (2017) · BMC Medical Genetics · doi:10.1186/s12881-017-0440-5 · Cited by 86 · see citing works

Sirtuin 2 deficiency aggravates ageing-induced vascular remodelling in humans and mice

Zhang, Y., Wang, X., Li, X.-K., Lv, S., Wang, H., Liu, Y., Zhou, J., Gong, H., Chen, X.-F., Ren, S., et al. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad381 · Cited by 82 · see citing works

Repurposing Medications for Treatment of Pulmonary Arterial Hypertension: What's Old Is New Again

Prins, K. W., Thenappan, T., Weir, Ε. K., Kalra, R., PRITZKER, M. R., & Archer, S. L. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.118.011343 · Cited by 79 · see citing works

Pathophysiology and pathogenic mechanisms of pulmonary hypertension: role of membrane receptors, ion channels, and Ca2+ signaling

Balistrieri, A., Makino, A., & Yuan, J. X. ‐. (2022) · Physiological Reviews · doi:10.1152/physrev.00030.2021 · Cited by 76 · see citing works

Skeletal muscle proteomic signature and metabolic impairment in pulmonary hypertension

Malenfant, S., Potus, F., Fournier, F., Breuils‐Bonnet, S., Pflieger, A., Bourassa, S., Tremblay, È., Nehmé, B., Droit, A., Bonnet, S., et al. (2014) · Journal of Molecular Medicine · doi:10.1007/s00109-014-1244-0 · Cited by 74 · see citing works

Melatonin ameliorates PM2.5‐induced cardiac perivascular fibrosis through regulating mitochondrial redox homeostasis

Jiang, J., Liang, S., Zhang, J., Du, Z., Xu, Q., Duan, J., & Sun, Z. (2020) · Journal of Pineal Research · doi:10.1111/jpi.12686 · Cited by 71 · see citing works

Melatonin protects against thoracic aortic aneurysm and dissection through SIRT1‐dependent regulation of oxidative stress and vascular smooth muscle cell loss

Xia, L., Sun, C., Zhu, H., Zhai, M., Zhang, L., Jiang, L., Hou, P., Li, J., Li, K., Liu, Z., et al. (2020) · Journal of Pineal Research · doi:10.1111/jpi.12661 · Cited by 72 · see citing works

Using mitochondrial sirtuins as drug targets: disease implications and available compounds

Gertz, M., & Steegborn, C. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2180-7 · Cited by 71 · see citing works

Melatonin protects hepatocytes against bile acid-induced mitochondrial oxidative stress via the AMPK-SIRT3-SOD2 pathway

Chen, Y., Qing, W., Sun, M., Lv, L., Guo, D., & Jiang, Y. (2015) · Free Radical Research · doi:10.3109/10715762.2015.1067806 · Cited by 71 · see citing works

Loss of Fatty Acid Binding Protein 4/aP2 Reduces Macrophage Inflammation Through Activation of SIRT3

Xu, H., Hertzel, A. V., Steen, K. A., & Bernlohr, D. (2016) · Molecular Endocrinology · doi:10.1210/me.2015-1301 · Cited by 70 · see citing works

Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension

Vilarinho, S., Sarı, S., Yılmaz, G., Stiegler, A. L., Boggon, T. J., Jain, D., Akyol, G., Dalgıç, B., Günel, M., & Lifton, R. P. (2016) · Hepatology · doi:10.1002/hep.28499 · Cited by 69 · see citing works

Sirtuin 1 regulates pulmonary artery smooth muscle cell proliferation

Zurlo, G., Piquereau, J., Moulin, M., Silva, J. P. D., Gressette, M., Ranchoux, B., Garnier, A., Ventura‐Clapier, R., Fadel, É., Humbert, M. J. C., et al. (2018) · Journal of Hypertension · doi:10.1097/hjh.0000000000001676 · Cited by 69 · see citing works

Roles of Sirtuins in Cardiovascular Diseases: Mechanisms and Therapeutics

Ding, Y.-N., Wang, H.-Y., Chen, X.-F., Tang, X., & Chen, H. (2025) · Circulation Research · doi:10.1161/circresaha.124.325440 · Cited by 67 · see citing works

Animal models of scleroderma: recent progress

Marangoni, R. G., Varga, J., & Tourtellotte, W. G. (2016) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000331 · Cited by 61 · see citing works

An Official American Thoracic Society Workshop Report: Obesity and Metabolism. An Emerging Frontier in Lung Health and Disease

Suratt, B. T., Ubags, N. D. J., Rastogi, D., Tantisira, K. G., Marsland, B. J., Petrache, I., Allen, J. B., Bates, J. H. T., Holguín, F., McCormack, M. C., et al. (2017) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201703-263ws · Cited by 58 · see citing works

Sirtuin 3: Emerging therapeutic target for cardiovascular diseases

Cao, M., Zhao, Q., Sun, X., Qian, H., Lyu, S., Chen, R., Xia, H., & Yuan, W. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.01.005 · Cited by 57 · see citing works

The emerging role of epigenetics in pulmonary hypertension

Gamen, E., Seeger, W., & Pullamsetti, S. S. (2016) · European Respiratory Journal · doi:10.1183/13993003.01714-2015 · Cited by 57 · see citing works

Emerging Metabolic Therapies in Pulmonary Arterial Hypertension

Harvey, L. D., & Chan, S. Y. (2017) · Journal of Clinical Medicine · doi:10.3390/jcm6040043 · Cited by 56 · see citing works

Identification of Celastramycin as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension

Kurosawa, R., Satoh, K., Kikuchi, N., Kikuchi, H., Saigusa, D., Al-Mamun, M. E., Siddique, M. A. H., Omura, J., Satoh, T., Sunamura, S., et al. (2019) · Circulation Research · doi:10.1161/circresaha.119.315229 · Cited by 55 · see citing works

Mitochondria in the Pulmonary Vasculature in Health and Disease: Oxygen‐Sensing, Metabolism, and Dynamics

Dasgupta, A., Wu, D., Tian, L., Xiong, P. Y., Dunham‐Snary, K. J., Chen, K., Alizadeh, E., Motamed, M., Potus, F., Hindmarch, C. C. T., et al. (2020) · Comprehensive physiology · doi:10.1002/cphy.c190027 · Cited by 55 · see citing works

Histone deacetylation contributes to low extracellular superoxide dismutase expression in human idiopathic pulmonary arterial hypertension

Nozik‐Grayck, E., Woods, C., Stearman, R. S., Venkataraman, S., Ferguson, B. S., Swain, K. E., Bowler, R. P., Geraci, M. W., Ihida‐Stansbury, K., Stenmark, K. R., et al. (2016) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00263.2015 · Cited by 54 · see citing works

Animals in Respiratory Research

Fröhlich, E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052903 · Cited by 53 · see citing works

Exploratory analysis of the neutrophil to lymphocyte ratio in patients with pulmonary arterial hypertension

Harbaum, L., Baaske, K. M., Simon, M., Oqueka, T., Sinning, C., Glatzel, A., Lüneburg, N., Sydow, K., Bokemeyer, C., & Klose, H. F. E. (2017) · BMC Pulmonary Medicine · doi:10.1186/s12890-017-0407-5 · Cited by 53 · see citing works

SIRT3 in cardiovascular diseases: Emerging roles and therapeutic implications

Lü, Y., Wang, Y., Wang, X., Chen, H., Cai, Z., & Xiang, M. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.06.236 · Cited by 52 · see citing works

Sirtuins Expression and Their Role in Retinal Diseases

Balaiya, S., Abu‐Amero, K. K., Kondkar, A. A., & Chalam, K. V. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/3187594 · Cited by 52 · see citing works

Altered mitochondrial acetylation profiles in a kainic acid model of temporal lobe epilepsy

Gano, L. B., Liang, L.-P., Ryan, K., Michel, C. R., Gomez, J., Vassilopoulos, A., Reisdorph, N. A., Fritz, K. S., & Patel, M. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.05.063 · Cited by 53 · see citing works

SIRT3 Deficiency Induces Endothelial Insulin Resistance and Blunts Endothelial-Dependent Vasorelaxation in Mice and Human with Obesity

Yang, L., Zhang, J., Xing, W., Zhang, X., Xu, J., Zhang, H., Chen, L., Ning, X., Ji, G., Li, J., et al. (2016) · Scientific Reports · doi:10.1038/srep23366 · Cited by 50 · see citing works

Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α Inhibits Vascular Calcification Through Sirtuin 3-Mediated Reduction of Mitochondrial Oxidative Stress

Feng, H., Wang, J.-Y., Yu, B., Cong, X., Zhang, W., Li, L., Liu, L., Zhou, Y., Zhang, C., Gu, P.-L., et al. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7620 · Cited by 49 · see citing works

Versatile role of sirtuins in metabolic disorders: From modulation of mitochondrial function to therapeutic interventions

Afzaal, A., Rehman, K., Kamal, S., & Akash, M. S. H. (2022) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23047 · Cited by 49 · see citing works

SUMOylation of Vps34 by SUMO1 promotes phenotypic switching of vascular smooth muscle cells by activating autophagy in pulmonary arterial hypertension

Yao, Y., Li, H., Da, X., He, Z., Tang, B., Li, Y., Hu, C., Xu, C., Chen, Q., & Wang, Q. K. (2019) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2019.01.007 · Cited by 49 · see citing works

Modulation of mitochondria and NADPH oxidase function by the nitrate-nitrite-NO pathway in metabolic disease with focus on type 2 diabetes

Schiffer, T. A., Lundberg, J. O., Weitzberg, E., & Carlström, M. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165811 · Cited by 48 · see citing works

Molecular mechanisms of right ventricular dysfunction in pulmonary arterial hypertension: focus on the coronary vasculature, sex hormones, and glucose/lipid metabolism

Agrawal, V., Lahm, T., Hansmann, G., & Hemnes, A. R. (2020) · Cardiovascular Diagnosis and Therapy · doi:10.21037/cdt-20-404 · Cited by 47 · see citing works

Capsaicin Attenuates Arterial Calcification Through Promoting SIRT6-Mediated Deacetylation and Degradation of Hif1α (Hypoxic-Inducible Factor-1 Alpha)

Luo, D., Li, W., Xie, C., Yin, L., Su, X., Chen, J., & Huang, H. (2022) · Hypertension · doi:10.1161/hypertensionaha.121.18778 · Cited by 46 · see citing works

SIRT1 is required for mitochondrial biogenesis reprogramming in hypoxic human pulmonary arteriolar smooth muscle cells

Li, P., Liu, Y., Burns, N., Zhao, K., & Song, R. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.2932 · Cited by 46 · see citing works

SIRT3 attenuates AngII-induced cardiac fibrosis by inhibiting myofibroblasts transdifferentiation via STAT3-NFATc2 pathway.

Guo, X., Yan, F., Li, J., Zhang, C., & Bu, P. (2017) · PubMed Central · Cited by 44 · see citing works

Epigenetic Modulation in the Initiation and Progression of Pulmonary Hypertension

Cheng, X., Wang, Y., & Du, L. (2019) · Hypertension · doi:10.1161/hypertensionaha.119.13458 · Cited by 43 · see citing works

The Warburg effect: A new story in pulmonary arterial hypertension

Peng, H., Xiao, Y., Deng, X., Luo, J.-F., Hong, C., & Qin, X. (2016) · Clinica Chimica Acta · doi:10.1016/j.cca.2016.07.017 · Cited by 41 · see citing works

SIRT3 prevents angiotensin II-induced renal tubular epithelial-mesenchymal transition by ameliorating oxidative stress and mitochondrial dysfunction

He, P., Li, Z., Yue, Z., Gao, H., Feng, G., Wang, P., Huang, Y., Luo, W., Hong, H., Liang, L., et al. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.04.027 · Cited by 41 · see citing works

Converging Paths of Pulmonary Arterial Hypertension and Cellular Senescence

van der Feen, D. E., Berger, R. M. F., & Bartelds, B. (2019) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2018-0329tr · Cited by 38 · see citing works

Arterial remodeling: the role of mitochondrial metabolism in vascular smooth muscle cells

Qin, H.-L., Bao, J., Tang, J., Xu, D., & Shen, L. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00074.2022 · Cited by 39 · see citing works

Novel Insights on Systemic and Brain Aging, Stroke, Amyotrophic Lateral Sclerosis, and Alzheimer’s Disease

Shetty, A. K., Upadhya, R., Madhu, L. N., & Kodali, M. (2019) · Aging and Disease · doi:10.14336/ad.2019.0330 · Cited by 39 · see citing works

Rats with a Human Mutation of NFU1 Develop Pulmonary Hypertension

Niihori, M., Eccles, C. A., Kurdyukov, S., Zemskova, M., Varghese, M. V., Степанова, А., Galkin, A. S., Rafikov, R., & Rafikova, O. (2019) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2019-0065oc · Cited by 39 · see citing works

Epigenetic Regulation and Its Therapeutic Potential in Pulmonary Hypertension

Wang, Y., Yan, L., Zhang, Z., Prado, E., Fu, L., Xu, X., & Du, L. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00241 · Cited by 37 · see citing works

Recent advances in mouse models for systemic sclerosis

Yue, X., Yu, X., Petersen, F., & Riemekasten, G. (2018) · Autoimmunity Reviews · doi:10.1016/j.autrev.2018.06.013 · Cited by 38 · see citing works

Metabolic syndrome, neurohumoral modulation, and pulmonary arterial hypertension

Maron, B. A., Leopold, J. A., & Hemnes, A. R. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14968 · Cited by 38 · see citing works

Glucocorticoid-induced fetal origins of adult hypertension: Association with epigenetic events

Anwar, M. A., Saleh, A. I., Olabi, R. A., Shehabi, T. S. A., & Eid, A. H. (2016) · Vascular Pharmacology · doi:10.1016/j.vph.2016.02.002 · Cited by 37 · see citing works

SIRT6 in Vascular Diseases, from Bench to Bedside

Ren, S., Chen, X., Gong, H., Wang, H., Wu, C. F., Li, P., Chen, X., Qu, J.-H., & Tang, X. (2022) · Aging and Disease · doi:10.14336/ad.2021.1204 · Cited by 35 · see citing works

Contribution of fatty acid oxidation to the pathogenesis of pulmonary hypertension

Lee, M. H., Sanders, L., Kumar, R., Hernández-Saavedra, D., Yun, X., Ford, J. A., Perez, M. J., Mickael, C. S., Gandjeva, A., Koyanagi, D. E., et al. (2022) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00039.2022 · Cited by 34 · see citing works

Emerging Therapies and Future Directions in Pulmonary Arterial Hypertension

Gurtu, V., & Michelakis, E. D. (2015) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2015.01.028 · Cited by 33 · see citing works

Redox Biology of Peroxisome Proliferator-Activated Receptor-γ in Pulmonary Hypertension

Tseng, V., Sutliff, R. L., & Hart, C. M. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7695 · Cited by 33 · see citing works

The yin and yang faces of the mitochondrial deacetylase sirtuin 3 in age-related disorders

Gomes, P., Viana, S., Nunes, S., Rolo, A. P., Palmeira, C. M., & Reis, F. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100983 · Cited by 33 · see citing works

New Insights into the Implication of Mitochondrial Dysfunction in Tissue, Peripheral Blood Mononuclear Cells, and Platelets during Lung Diseases

Riou, M., Alfatni, A., Charles, A., Andrès, E., Pistea, C., Charloux, A., & Gény, B. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051253 · Cited by 33 · see citing works

Mild endothelial dysfunction in Sirt3 knockout mice fed a high-cholesterol diet: protective role of a novel C/EBP-β-dependent feedback regulation of SOD2

Winnik, S. H., Gaul, D. S., Siciliani, G., Lohmann, C., Pasterk, L., Calatayud, N., Weber, J., Eriksson, U., Auwerx, J. H., van Tits, L. J., et al. (2016) · Basic Research in Cardiology · doi:10.1007/s00395-016-0552-7 · Cited by 33 · see citing works

Metformin Therapy for Pulmonary Hypertension Associated with Heart Failure with Preserved Ejection Fraction versus Pulmonary Arterial Hypertension

Goncharov, D. A., Goncharova, E. A., Tofovic, S. P., HU, J. L., Baust, J., Pena, A. Z., Ray, A., Rode, A., Vanderpool, R. R., Mora, A. L., et al. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201801-0022le · Cited by 33 · see citing works

Abstract 18830: Mitochondrial Suppression Due to Loss of Sirt3 Deacetylase Activity Causes Pulmonary Arterial Hypertension

Paulin, R., Dromparis, P., Sutendra, G., Provencher, S., Bonnet, S., & Michelakis, E. D. (2013) · Circulation · doi:10.1161/circ.128.suppl_22.a18830

Abstract 17011: Loss-of-function SIRT3 Single Nucleotide Polymorphisms in Patients With Pulmonary Arterial Hypertension (PAH): Insights into the Metabolic Basis of PAH

Gurtu, V., Paulin, R., Webster, L., PATERSON, I. S., Provencher, S., Bonnet, S., & Michelakis, E. D. (2013) · Circulation

Abstract 19386: The Mitochondrial Deacetylase Sirtuin 3 (sirt3) is Important in the Pathogenesis of Both Pulmonary Hypertension and Pulmonary Fibrosis: Potential for an “Overlap Syndrome” and a Common Therapy?

Paulin, R., Zang, H., Boukouris, A. E., Gurtu, V., Haromy, A., & Michelakis, E. D. (2015) · Circulation · doi:10.1161/circ.132.suppl_3.19386

Abstract 13575: Lack of Both Mitochondrial Proteins Sirt3 and Ucp2 in Mice Recapitulates Many Critical Features of Human Pulmonary Arterial Hypertension (PAH), Including Inflammatory Plexogenic Lesions, Supporting the Metabolic Theory of PAH

Zhang, Y., Zervopoulos, S. D., Boukouris, A. E., Saleme, B., Liu, Y., Haromy, A., Webster, L., Dakhili, S. A. T., Ussher, J. R., Sutendra, G., et al. (2020) · Circulation · doi:10.1161/circ.142.suppl_3.13575

SIRT3 Is a Critical Regulator of Mitochondrial Function of Fibroblasts in Pulmonary Hypertension

Li, M., Plecitá‐Hlavatá, L., Dobrinskikh, E., McKeon, B. A., Gandjeva, A., Riddle, S. R., Laux, A., Prasad, R. R., Kumar, S., Tuder, R. M., et al. (2023) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2022-0360oc · Cited by 34 · see citing works