Chronic intermittent hypoxia mimicking sleep apnoea increases spontaneous tumorigenesis in mice
Open accessAbstract
Obstructive sleep apnoea (OSA) is a very prevalent disorder with well proven mid- and long-term deleterious consequences, such as increased risk of cardiovascular, metabolic and neurocognitive diseases [1]. Recently, considerable data from both animal models and patient studies also suggest that OSA increases the risk of cancer incidence and mortality [2]. Some of these studies indicate that nocturnal hypoxic events experienced by OSA patients as a consequence of recurrent upper airway obstructions may be a main challenge driving tumour progression [3, 4]. Although the clinical and experimental data available do not undoubtedly prove a relationship between cancer and OSA [5], its plausibility has raised the interest of basic and clinical researchers in the field, warranting further investigation [6]. Chronic intermittent hypoxia mimicking sleep apnoea increases spontaneous tumorigenesis in mice The authors thank Ana Gordillo (Universidad de Valladolid/CIBERES, Valladolid, Spain) for her technical support.
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In mouse models, cyclical intermittent hypoxia increases spontaneous tumorigenesis.
“increases spontaneous tumorigenesis,889”
From International Consensus Statement on Obstructive Sleep Apnea (2023) · cites this paper as [889]
The study reports increased spontaneous tumours in aged mice exposed to severe intermittent hypoxia, with a statistically significant difference from controls. Its discussion specifies that relatively severe, but not mild, intermittent hypoxia increased spontaneous tumorigenesis; the claim omits that distinction. (LLM, conf=0.88)
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Cites
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Intermittent hypoxia increases melanoma metastasis to the lung in a mouse model of sleep apnea
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Self-citationTumor Cell Malignant Properties Are Enhanced by Circulating Exosomes in Sleep Apnea
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International Consensus Statement on Obstructive Sleep Apnea
Chang, J. L., Goldberg, A. N., Alt, J. A., Mohammed, A., Ashbrook, L., Auckley, D., Ayappa, I., Bakhtiar, H., Barrera, J. E., Bartley, B. L., et al. (2023) · International Forum of Allergy & Rhinology · doi:10.1002/alr.23079 · Cited by 350 · see citing works
- Authors
- Gallego-Martin, T., Farré, R., Almendros, I., Gonzalez-Obeso, E., & Obeso, A.
- Affiliations
- Instituto de Salud Carlos III (ES)
- Universidad de Valladolid (ES)
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2017-02
- Volume
- 49
- Issue
- 2
- Pages
- 1602111
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2587909879
- Semantic Scholar
- 603908530b1c489f86062ba14f41f05c0cc40873
- Cited by
- 36
- References
- 14
- Citations by year
- 2025: 5 · 2024: 1 · 2023: 5 · 2022: 6 · 2021: 1 · 2020: 5 · 2019: 8 · 2018: 4 · 2017: 1
- FWCI
- 3.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Respiratory Journal (publishedVersion)
- PubMed (publishedVersion)
- UVaDOC UVaDOC University of Valladolid Documentary Repository (University of Valladolid) (publishedVersion, other-oa)
- Funders
- Instituto de Salud Carlos III (BFU2015-70616-R, PI2014-00004)
- Fundación Científica Asociación Española Contra el Cáncer (APRO-I Valladolid)
- CIBER de Enfermedades Respiratorias (CB06/06/0050)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
- Keywords
- obstructive sleep apnea, chronic intermittent hypoxia, spontaneous tumor development, cancer risk, nocturnal hypoxia, upper airway obstruction, tumor progression, mice
- MeSH terms
- Animals, Hypoxia, Disease Models, Animal, Male, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasms, Oxygen, Sleep, Sleep Apnea Syndromes, Time Factors, Mice, Carcinogenesis
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