The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Air pollution, lung function and COPD: results from the population-based UK Biobank study
Open accessAbstract
Ambient air pollution increases the risk of respiratory mortality, but evidence for impacts on lung function and chronic obstructive pulmonary disease (COPD) is less well established. The aim was to evaluate whether ambient air pollution is associated with lung function and COPD, and explore potential vulnerability factors. We used UK Biobank data on 303 887 individuals aged 40–69 years, with complete covariate data and valid lung function measures. Cross-sectional analyses examined associations of land use regression-based estimates of particulate matter (particles with a 50% cut-off aerodynamic diameter of 2.5 and 10 µm: PM 2.5 and PM 10, respectively; and coarse particles with diameter between 2.5 μm and 10 μm: PM coarse) and nitrogen dioxide (NO 2) concentrations with forced expiratory volume in 1 s (FEV 1), forced vital capacity (FVC), the FEV 1/FVC ratio and COPD (FEV 1/FVC <lower limit of normal). Effect modification was investigated for sex, age, obesity, smoking status, household income, asthma status and occupations previously linked to COPD. Higher exposures to each pollutant were significantly associated with lower lung function. A 5 µg·m−3 increase in PM 2.5 concentration was associated with lower FEV 1(−83.13 mL, 95% CI −92.50– −73.75 mL) and FVC (−62.62 mL, 95% CI −73.91– −51.32 mL). COPD prevalence was associated with higher concentrations of PM 2.5(OR 1.52, 95% CI 1.42–1.62, per 5 µg·m−3), PM 10(OR 1.08, 95% CI 1.00–1.16, per 5 µg·m−3) and NO 2(OR 1.12, 95% CI 1.10–1.14, per 10 µg·m−3), but not with PM coarse. Stronger lung function associations were seen for males, individuals from lower income households, and “at-risk” occupations, and higher COPD associations were seen for obese, lower income, and non-asthmatic participants. Ambient air pollution was associated with lower lung function and increased COPD prevalence in this large study.
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Quanjer, P. H., Stanojevic, S., Cole, T. J., Baur, X., Hall, G. L., Culver, B. H., Enright, P. L., Hankinson, J. L., Ip, M. S. M., Zheng, J., et al. (2012) · European Respiratory Journal · doi:10.1183/09031936.00080312 · Cited by 5,919
Global Initiative for Chronic Obstructive Lung Disease (GOLD)
Rahman, M. M., & Siddiqui, M. M. R. (2017) · Anwer Khan Modern Medical College Journal · doi:10.3329/akmmcj.v7i1.31596 · Cited by 3,106
Eeftens, M., Beelen, R., de Hoogh, K., Bellander, T., Cesaroni, G., Cirach, M., Declercq, C., Dėdelė, A., Dons, E., de Nazelle, A., et al. (2012) · Environmental Science & Technology · doi:10.1021/es301948k · Cited by 1,214
Self-citationBeelen, R., Hoek, G., Vienneau, D., Eeftens, M., Dimakopoulou, K., Pedeli, X., Tsai, M.-Y., Künzli, N., Schikowski, T., Marcon, A., et al. (2013) · Atmospheric Environment · doi:10.1016/j.atmosenv.2013.02.037 · Cited by 1,014
Self-citationA Growing Role for Gender Analysis in Air Pollution Epidemiology
Clougherty, J. E. (2010) · Environmental Health Perspectives · doi:10.1289/ehp.0900994 · Cited by 606
UK Biobank: Current status and what it means for epidemiology
Allen, N., Sudlow, C., Downey, P., Peakman, T., Danesh, J., Elliott, P., Gallacher, J., Green, J., Matthews, P., Pell, J., et al. (2012) · Health Policy and Technology · doi:10.1016/j.hlpt.2012.07.003 · Cited by 521
Dubowsky, S. D., Suh, H., Schwartz, J., Coull, B. A., & Gold, D. R. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.8469 · Cited by 435
Long-term air pollution exposure and living close to busy roads are associated with COPD in women
Schikowski, T., Sugiri, D., Ranft, U., Gehring, U., Heinrich, J., Wichmann, H.-E., & Krämer, U. (2005) · Respiratory Research · doi:10.1186/1465-9921-6-152 · Cited by 419
Ackermann-Liebrich, U., Leuenberger, P., Schwartz, J., Schindler, C., Monn, C., Bolognini, G., Bongard, J. P., Brändli, O., Domenighetti, G., Elsasser, S., et al. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.1.9001300 · Cited by 386
Cited by
Mechanisms of ultrafine particle-induced respiratory health effects
Leikauf, G. D., Kim, S.-H., & Jang, A.-S. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0394-0 · Cited by 322
Association Between Short-term Exposure to Environmental Air Pollution and Psoriasis Flare
Bellinato, F., Adami, G., Vaienti, S., Benini, C., Gatti, D., Idolazzi, L., Fassio, A., Rossini, M., Girolomoni, G., & Gisondi, P. (2022) · JAMA Dermatology · doi:10.1001/jamadermatol.2021.6019 · Cited by 101
Exposure to Air Pollution, Genetic Susceptibility, and Psoriasis Risk in the UK
Wu, J., Ma, Y., Yang, J., & Tian, Y. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.21665 · Cited by 38
Metadata
- Authors
- Doiron, D., de Hoogh, K., Probst-Hensch, N., Fortier, I., Cai, Y., De Matteis, S., & Hansell, A. L.
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2019-07
- Volume
- 54
- Issue
- 1
- Pages
- 1802140
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W2947803926
- Cited by
- 490
- References
- 35
- FWCI
- 19.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Doiron, D., de Hoogh, K., Probst-Hensch, N., Fortier, I., Cai, Y., De Matteis, S., & Hansell, A. L. (2019). Air pollution, lung function and COPD: results from the population-based UK Biobank study. European Respiratory Journal. https://doi.org/10.1183/13993003.02140-2018
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