The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Diabetes, Obesity, and Hypertension May Enhance Associations between AirPollution and Markers of Systemic Inflammation
Open accessAbstract
Airborne particulate matter (PM) may lead to increased cardiac risk through an inflammatory pathway. Therefore, we investigated associations between ambient PM and markers of systemic inflammation among repeated measures from 44 senior citizens (>/= 60 years of age) and examined susceptibility by conditions linked to chronic inflammation. Mixed models were used to identify associations between concentrations of fine PM [aerodynamic diameter </= 2.5 microm (PM2.5)] averaged over 1-7 days and measures of C-reactive protein (CRP) , interleukin-6 (IL-6) , and white blood cells (WBCs) . Effect modification was investigated for diabetes, obesity, hypertension, and elevated mean inflammatory markers. We found positive associations between longer moving averages of PM2.5 and WBCs across all participants, with a 5.5% [95% confidence interval (CI) , 0.10 to 11%] increase per interquartile increase (5.4 microg/m3) of PM2.5 averaged over the previous week. PM2.5 and CRP also exhibited positive associations among all individuals for averages longer than 1 day, with the largest associations for persons with diabetes, obesity, and hypertension. For example, an interquartile increase in the 5-day mean PM)2.5 (6.1 microg/m3) was associated with a 14% increase in CRP (95% CI, -5.4 to 37%) for all individuals and an 81% (95% CI, 21 to 172%) increase for persons with diabetes, obesity, and hypertension. Persons with diabetes, obesity, and hypertension also exhibited positive associations between PM2.5 and IL-6. Individuals with elevated mean inflammatory markers exhibited enhanced associations with CRP, IL-6, and WBCs. We found modest positive associations between PM2.5 and indicators of systemic inflammation, with larger associations suggested for individuals with diabetes, obesity, hypertension, and elevated mean inflammatory markers.
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Citations
Cites
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THE IMPACT OF CONFOUNDER SELECTION CRITERIA ON EFFECT ESTIMATION
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RE:“;THE IMPACT OF CONFOUNDER SELECTION CRITERIA ON EFFECT ESTIMATION”
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Cited by
Brook, R. D., Rajagopalan, S., Pope, C. A., Brook, J. R., Bhatnagar, A., Diez-Roux, A. V., Holguin, F., Hong, Y., Luepker, R. V., Mittleman, M. A., et al. (2010) · Circulation · doi:10.1161/cir.0b013e3181dbece1 · Cited by 6,548
Chuang, K.-J., Chan, C.-C., Su, T.-C., Lee, C.-T., & Tang, C.-S. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200611-1627oc · Cited by 685
Power, M. C., Kioumourtzoglou, M.-A., Hart, J. E., Okereke, O. I., Laden, F., & Weisskopf, M. G. (2015) · BMJ · doi:10.1136/bmj.h1111 · Cited by 377
Air pollution and circulating biomarkers of oxidative stress
Delfino, R. J., Staimer, N., & Vaziri, N. D. (2011) · Air Quality, Atmosphere & Health · doi:10.1007/s11869-010-0095-2 · Cited by 181
Short-term exposure to air pollution and inflammation-sensitive biomarkers
Steinvil, A., Kordova-Biezuner, L., Shapira, I., Berliner, S., & Rogowski, O. (2008) · Environmental Research · doi:10.1016/j.envres.2007.08.006 · Cited by 120
Metadata
- Authors
- Dubowsky, S. D., Suh, H., Schwartz, J., Coull, B. A., & Gold, D. R.
- Venue
- Environmental Health Perspectives
- Publisher
- American Chemical Society (ACS)
- Published
- 2006-07
- Volume
- 114
- Issue
- 7
- Pages
- 992-998
- ISSN
- 0091-6765 (ISSN-L)
- 1552-9924
- OpenAlex
- W2102068617
- Cited by
- 435
- References
- 44
- FWCI
- 12.14
- Type
- journal article
- Language
- en
- Open access
- gold
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- Dubowsky, S. D., Suh, H., Schwartz, J., Coull, B. A., & Gold, D. R. (2006). Diabetes, Obesity, and Hypertension May Enhance Associations between AirPollution and Markers of Systemic Inflammation. Environmental Health Perspectives. https://doi.org/10.1289/ehp.8469
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