The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Cardiopulmonary recovery after COVID-19: an observational prospective multicentre trial
Open accessAbstract
Background: After the 2002/2003 severe acute respiratory syndrome outbreak, 30% of survivors exhibited persisting structural pulmonary abnormalities. The long-term pulmonary sequelae of coronavirus disease 2019 (COVID-19) are yet unknown, and comprehensive clinical follow-up data are lacking. Methods: In this prospective, multicentre, observational study, we systematically evaluated the cardiopulmonary damage in subjects recovering from COVID-19 at 60 and 100 days after confirmed diagnosis. We conducted a detailed questionnaire, clinical examination, laboratory testing, lung function analysis, echocardiography and thoracic low-dose computed tomography (CT). Results: Data from 145 COVID-19 patients were evaluated, and 41% of all subjects exhibited persistent symptoms 100 days after COVID-19 onset, with dyspnoea being most frequent (36%). Accordingly, patients still displayed an impaired lung function, with a reduced diffusing capacity in 21% of the cohort being the most prominent finding. Cardiac impairment, including a reduced left ventricular function or signs of pulmonary hypertension, was only present in a minority of subjects. CT scans unveiled persisting lung pathologies in 63% of patients, mainly consisting of bilateral ground-glass opacities and/or reticulation in the lower lung lobes, without radiological signs of pulmonary fibrosis. Sequential follow-up evaluations at 60 and 100 days after COVID-19 onset demonstrated a vast improvement of symptoms and CT abnormalities over time. Conclusion: A relevant percentage of post-COVID-19 patients presented with persisting symptoms and lung function impairment along with radiological pulmonary abnormalities >100 days after the diagnosis of COVID-19. However, our results indicate a significant improvement in symptoms and cardiopulmonary status over time.
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Ceban, F., Ling, S., Lui, L. M. W., Lee, Y., Gill, H., Teopiz, K. M., Rodrigues, N. B., Subramaniapillai, M., Di Vincenzo, J. D., Cao, B., et al. (2022) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2021.12.020 · Cited by 1,554
Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments
Yong, S. J. (2021) · Infectious Diseases · doi:10.1080/23744235.2021.1924397 · Cited by 1,339
1-year outcomes in hospital survivors with COVID-19: a longitudinal cohort study.
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Characterising long COVID: a living systematic review
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Metadata
- Authors
- Sonnweber, T., Sahanic, S., Pizzini, A., Luger, A., Schwabl, C., Sonnweber, B., Kurz, K., Koppelstätter, S., Haschka, D., Petzer, V., Boehm, A., Aichner, M., Tymoszuk, P., Lener, D., Theurl, M., Lorsbach-Köhler, A., Tancevski, A., Schapfl, A., Schaber, M., Hilbe, R., Nairz, M., Puchner, B., Hüttenberger, D., Tschurtschenthaler, C., Aßhoff, M., Peer, A., Hartig, F., Bellmann, R., Joannidis, M., Gollmann-Tepeköylü, C., Holfeld, J., Feuchtner, G., Egger, A., Hoermann, G., Schroll, A., Fritsche, G., Wildner, S., Bellmann-Weiler, R., Kirchmair, R., Helbok, R., Prosch, H., Rieder, D., Trajanoski, Z., Kronenberg, F., Wöll, E., Weiss, G., Widmann, G., Löffler-Ragg, J., & Tancevski, I.
- Venue
- European Respiratory Journal
- Publisher
- European Respiratory Society (ERS)
- Published
- 2020-12-10
- Volume
- 57
- Issue
- 4
- Pages
- 2003481
- ISSN
- 0903-1936 (ISSN-L)
- 1399-3003
- OpenAlex
- W3113305178
- Cited by
- 432
- References
- 30
- FWCI
- 32.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Sonnweber, T., Sahanic, S., Pizzini, A., Luger, A., Schwabl, C., Sonnweber, B., Kurz, K., Koppelstätter, S., Haschka, D., Petzer, V., Boehm, A., Aichner, M., Tymoszuk, P., Lener, D., Theurl, M., Lorsbach-Köhler, A., Tancevski, A., Schapfl, A., Schaber, M., . . . Tancevski, I. (2021). Cardiopulmonary recovery after COVID-19: an observational prospective multicentre trial. European Respiratory Journal. https://doi.org/10.1183/13993003.03481-2020
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