Cited by 221Chronic Obstructive Pulmonary Disease (COPD) ResearchAsthma and respiratory diseasesInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

The DOI matches its Crossref record; 157 of the 157 references it cites were found in a registry or an index.

Lung ageing and COPD: is there a role for ageing in abnormal tissue repair?

Open access

Brandsma, Corry-Anke, de Vries, Maaike, Costa, Rita, Woldhuis, Roy R., Königshoff, Melanie, Timens, Wim·2017·European Respiratory Review

DOI 10.1183/16000617.0073-2017PMC PMC9488745

Open this paper in CoChat — free account Open PDF

Abstract

Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide, with increasing prevalence, in particular in the elderly. COPD is characterised by abnormal tissue repair resulting in (small) airways disease and emphysema. There is accumulating evidence that ageing hallmarks are prominent features of COPD. These ageing hallmarks have been described in different subsets of COPD patients, in different lung compartments and also in a variety of cell types, and thus might contribute to different COPD phenotypes. A better understanding of the main differences and similarities between normal lung ageing and the pathology of COPD may improve our understanding of the mechanisms driving COPD pathology, in particular in those patients that develop the most severe form of COPD at a relatively young age, i.e. severe early-onset COPD patients. In this review, after introducing the main concepts of lung ageing and COPD pathology, we focus on the role of (abnormal) ageing in lung remodelling and repair in COPD. We discuss the current evidence for the involvement of ageing hallmarks in these pathological features of COPD. We also highlight potential novel treatment strategies and opportunities for future research based on our current knowledge of abnormal lung ageing in COPD.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1183/16000617.0073-2017

Cites

157 of 157 references verified0 citation errors · 0 not checkable

Statistics

FIGURE 1 Pathological changes in chronic obstructive pulmonary disease. a) Characteristic picture of airways changes, with increase of goblet cells, a thickened airway wall with some adventitial inflammation, and a small lymphoid follicle at the left upper side. Emphysema is hardly present here. Haematoxylin and eosin, ×200 magnification, scale bar=200 μm. Inset shows magnification of part of the airway with a lymphoid follicle; scale bar=50 μm. b) At the left, an almost longitudinal cross-section of a small airway, and at the right, severe parenchymal destruction by emphysema. Haematoxylin and eosin, ×100 magnification, scale bar=500 μm.CC BY-NC · PubMed Central

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Hallmarks of Aging
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
DNA methylation age of human tissues and cell types
Horvath, S. (2013) · Genome Biology · doi:10.1186/gb-2013-14-10-r115 · Cited by 7,075
Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358
Genome-wide methylation profiles reveal quantitative views of human aging rates
Hannum, G., Guinney, J., Zhao, L., Zhang, L., Hughes, G., Sadda, S., Klotzle, B., Bibikova, M., Fan, J.-B., Gao, Y., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.10.016 · Cited by 4,270
The Nature of Small-Airway Obstruction in Chronic Obstructive Pulmonary Disease
Hogg, J. C., Chu, F. S. F., Utokaparch, S., Woods, R. R., Elliott, W. M., Buzatu, L., Cherniack, R. M., Rogers, R. M., Sciurba, F. C., Coxson, H. O., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032158 · Cited by 3,828
Susceptibility to Exacerbation in Chronic Obstructive Pulmonary Disease
Hurst, J. R., Vestbo, J., Anzueto, A. R., Locantore, N., Müllerová, H., Tal‐Singer, R., Miller, B. E., Lomas, D. A., Agustí, A. G. N., MacNee, W., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0909883 · Cited by 2,983
Chronic Obstructive Pulmonary Disease
Flavin, K., Morkane, C. M., & Marsh, S. (2018) · Cambridge University Press eBooks · doi:10.1017/9781108233712.025 · Cited by 2,687
Evolution of ageing
Kirkwood, T. B. L. (1977) · Nature · doi:10.1038/270301a0 · Cited by 2,007
Understanding the odd science of aging
Kirkwood, T. B. L. (2005) · Cell · doi:10.1016/j.cell.2005.01.027 · Cited by 1,984
Type 2 alveolar cells are stem cells in adult lung
Barkauskas, C. E., Cronce, M. J., Rackley, C. R., Bowie, E. J., Keene, D. R., Stripp, B. R., Randell, S. H., Noble, P. W., & Hogan, B. L. M. (2013) · Journal of Clinical Investigation · doi:10.1172/jci68782 · Cited by 1,776

Show all 157 references

Research works printed but not linked: 1

10.1146/annurev.pathol.4.110807.092145 · DOI

Sorted by citations

Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments
Zuo, L., Prather, E. R., Stetskiv, M., Garrison, D. E., Meade, J. R., Peace, T. I., & Zhou, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184472 · Cited by 560
Toll-like receptor 4 (TLR4): new insight immune and aging
Kim, H., Kim, H., Lee, J., & Hwangbo, C. (2023) · Immunity & Ageing · doi:10.1186/s12979-023-00383-3 · Cited by 500
Aging and Lung Disease
Cho, S. J., & Stout-Delgado, H. W. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034610 · Cited by 458
Plasma protein-based organ-specific aging and mortality models unveil diseases as accelerated aging of organismal systems
Goeminne, L. J. E., Vladimirova, A., Eames, A., Tyshkovskiy, A., Argentieri, M. A., Ying, K., Moqri, M., & Gladyshev, V. N. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.10.005 · Cited by 163
Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases
Blokland, K. E. C., Pouwels, S. D., Schuliga, M. J., Knight, D. A., & Burgess, J. K. (2020) · Clinical Science · doi:10.1042/cs20190893 · Cited by 132
Exposome and unhealthy aging: environmental drivers from air pollution to occupational exposures
Pándics, T., Major, D., Fazekas‐Pongor, V., Szarvas, Z., Péterfi, A., Mukli, P., Gulej, R., Ungvari, A., Fekete, M., Tompa, A., et al. (2023) · GeroScience · doi:10.1007/s11357-023-00913-3 · Cited by 137
Targeting Aging Pathways in Chronic Obstructive Pulmonary Disease
Easter, M., Bollenbecker, S., Barnes, J. W., & Krick, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186924 · Cited by 130
Monoamine oxidases in age-associated diseases: New perspectives for old enzymes
Santin, Y., Resta, J., Parini, A., & Mialet‐Perez, J. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101256 · Cited by 110
Stem cells and lung regeneration
Parekh, K. R., Nawroth, J. C., Pai, A. C., Busch, S. M., Senger, C. N., & Ryan, A. L. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00036.2020 · Cited by 98
Vascular Niche in Lung Alveolar Development, Homeostasis, and Regeneration
Mammoto, A., & Mammoto, T. (2019) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00318 · Cited by 85
Long Noncoding Transcriptome in Chronic Obstructive Pulmonary Disease
Devadoss, D., Long, C., Langley, R. J., Manevski, M., Nair, M. G., Campos, M., Borchert, G. M., Rahman, I., & Chand, H. S. (2019) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2019-0184tr · Cited by 76
Tuberculosis in an Aging World
Olmo-Fontánez, A. M., & Turner, J. (2022) · Pathogens · doi:10.3390/pathogens11101101 · Cited by 84
Immunologic and Non-Immunologic Mechanisms Leading to Airway Remodeling in Asthma
Fang, L., Sun, Q., & Roth, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030757 · Cited by 71
Link between increased cellular senescence and extracellular matrix changes in COPD
Woldhuis, R. R., de Vries, M., Timens, W., van den Berge, M., Demaria, M., Oliver, B. G. G., Heijink, I. H., & Brandsma, C. (2020) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00028.2020 · Cited by 74
Self-citation
Pulmonary non-tuberculous mycobacterial infections: current state and future management
Chin, K. L., Sarmiento, M. E., Álvarez, N., Norazmi, M. N., & Acosta, A. (2019) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-019-03771-0 · Cited by 66
COPD-derived fibroblasts secrete higher levels of senescence-associated secretory phenotype proteins
Woldhuis, R. R., Heijink, I. H., van den Berge, M., Timens, W., Oliver, B. G. G., de Vries, M., & Brandsma, C. (2020) · Thorax · doi:10.1136/thoraxjnl-2020-215114 · Cited by 65
Self-citation
Epithelial cell senescence induces pulmonary fibrosis through Nanog-mediated fibroblast activation
Chen, X., Xu, H., Hou, J., Wang, H., Zheng, Y., Li, H., Cai, H., Han, X., & Dai, J. (2019) · Aging · doi:10.18632/aging.102613 · Cited by 60
Endothelial dysfunction in COPD: a systematic review and meta-analysis of studies using different functional assessment methods
Theodorakopoulou, M. P., Alexandrou, M. E., Bakaloudi, D. R., Pitsiou, G., Stanopoulos, I., Kontakiotis, T., & Boutou, A. (2021) · ERJ Open Research · doi:10.1183/23120541.00983-2020 · Cited by 56
Role of Molecular Hydrogen in Ageing and Ageing‐Related Diseases
Fu, Z., Zhang, J., & Zhang, Y. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2249749 · Cited by 53
Age-associated differences in the human lung extracellular matrix
Ngassie, M. L. K., de Vries, M., Borghuis, T., Timens, W., Sin, D. D., Nickle, D. C., Joubert, P., Horvatovich, P. L., Marko‐Varga, G., Teske, J. J., et al. (2023) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00334.2022 · Cited by 48
Self-citation
Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants
Zhao, X., Qiao, D., Yang, C., Kasela, S., Kim, W., Ma, Y., Shrine, N. R. G., Batini, C., Sofer, T., Taliun, S. A. G., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18334-7 · Cited by 49
Lnc-IL7R alleviates PM2.5-mediated cellular senescence and apoptosis through EZH2 recruitment in chronic obstructive pulmonary disease
Lee, K., Ho, S., Sun, W.-L., Feng, P., Lin, C., Chen, K.-Y., Chuang, H., Tseng, C., Chen, T.-T., & Wu, S. (2022) · Cell Biology and Toxicology · doi:10.1007/s10565-022-09709-1 · Cited by 41
Histological and Physiological Studies of the Effect of Bone Marrow-Derived Mesenchymal Stem Cells on Bleomycin Induced Lung Fibrosis in Adult Albino Rats
Zakaria, D. M., Zahran, N. M., Arafa, S. A., Mehanna, R. A., & Abd-el-Moneim, R. (2020) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-020-00294-0 · Cited by 40
The relation between age and airway epithelial barrier function
de Vries, M., Nwozor, K. O., Muizer, K., Wisman, M., Timens, W., van den Berge, M., Faiz, A., Hackett, T., Heijink, I. H., & Brandsma, C. (2022) · Respiratory Research · doi:10.1186/s12931-022-01961-7 · Cited by 41
Self-citation
Endothelial HIF-2α as a Key Endogenous Mediator Preventing Emphysema
Pasupneti, S., Tian, W., Tu, A. B., Dahms, P. A., Granucci, E. J., Gandjeva, A., Xiang, M., Butcher, E. C., Semenza, G. L., Tuder, R. M., et al. (2020) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202001-0078oc · Cited by 38
Unveiling mechanisms of lung aging in COPD: A promising target for therapeutics development
Devulder, J. V. (2024) · Chinese Medical Journal - Pulmonary and Critical Care Medicine · doi:10.1016/j.pccm.2024.08.007 · Cited by 42
A Drosophila model of cigarette smoke induced COPD identifies Nrf2 signaling as an expedient target for intervention
Prange, R. D., Thiedmann, M., Bhandari, A., Mishra, N., Sinha, A. N., Häsler, R., Rosenstiel, P. C., Uliczka, K., Wagner, C., Yildirim, A. Ö., et al. (2018) · Aging · doi:10.18632/aging.101536 · Cited by 40
Why Does an Aging Smoker’s Lung Develop Idiopathic Pulmonary Fibrosis and Not Chronic Obstructive Pulmonary Disease?
Selman, M., Martínez, F. J., & Pardo, A. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201806-1166pp · Cited by 37
Clinical trial on the effects of oral magnesium supplementation in stable-phase COPD patients
Zanforlini, B. M., Ceolin, C., Trevisan, C., Alessi, A., Seccia, D. M., Noale, M., Maggi, S., Guarnieri, G., Vianello, A., & Sergi, G. (2021) · Aging Clinical and Experimental Research · doi:10.1007/s40520-021-01921-z · Cited by 35
Role of cellular senescence in inflammatory lung diseases
Xie, C. H., Yalikun, M., Luo, Q., & Dong, J. (2023) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2023.02.001 · Cited by 31
Frequent Outpatient Visits Prevent Exacerbation of Chronic Obstructive Pulmonary Disease
Park, H. J., Byun, M. K., Kim, T., Rhee, C. K., Kim, K., Kim, B., Ahn, S. I., Jo, Y. U., & Yoo, K. H. (2020) · Scientific Reports · doi:10.1038/s41598-020-63064-x · Cited by 33
Changing trends in the air pollution–related disease burden from 1990 to 2019 and its predicted level in 25 years
Hu, W., Fang, L., Zhang, H., Ni, R., & Pan, G. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-22318-z · Cited by 33
Airway Epithelium Senescence as a Driving Mechanism in COPD Pathogenesis
Bateman, G., Guo-Parke, H., Rodgers, A. M., Linden, D. A., Bailey, M., Weldon, S., Kidney, J. C., & Taggart, C. C. (2023) · Biomedicines · doi:10.3390/biomedicines11072072 · Cited by 39
The The Impact of Upper Limb Training with Breathing Maneuver in Lung Function, Functional Capacity, Dyspnea Scale, and Quality of Life in Patient with Stable Chronic Obstructive of Lung Disease
Tarigan, A. P., Ananda, F. R., Pandia, P., Sinaga, B. Y. M., Maryaningsih, M., & Anggriani, A. (2019) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2019.113 · Cited by 32
Association between dual use of e-cigarette and cigarette and chronic obstructive pulmonary disease: an analysis of a nationwide representative sample from 2013 to 2018
Kim, T., & Kang, J. (2021) · BMC Pulmonary Medicine · doi:10.1186/s12890-021-01590-8 · Cited by 32
Time‐resolved proteomic profiling of cigarette smoke‐induced experimental chronic obstructive pulmonary disease
Skerrett-Byrne, D. A., Bromfield, E. G., Murray, H. C., Jamaluddin, M. F. B., Jarnicki, A., Fricker, M., Essilfie, A., Jones, B., Haw, T. J., Hampsey, D. M., et al. (2021) · Respirology · doi:10.1111/resp.14111 · Cited by 36
Redox Dysregulation in Aging and COPD: Role of NOX Enzymes and Implications for Antioxidant Strategies
Schiffers, C., Reynaert, N. L., Wouters, E. F. �., & van der Vliet, A. (2021) · Antioxidants · doi:10.3390/antiox10111799 · Cited by 31
Tongue cleaning in the elderly and its role in the respiratory and swallowing functions: Benefits and medical perspectives
Izumi, M., & Akifusa, S. (2021) · Journal of Oral Rehabilitation · doi:10.1111/joor.13266 · Cited by 30
Cellular senescence is a key mediator of lung aging and susceptibility to infection
Torrance, B. L., & Haynes, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1006710 · Cited by 28
Targeting anti‐aging protein sirtuin (Sirt) in the diagnosis of idiopathic pulmonary fibrosis
Shaikh, S. B., Prabhu, A., & Bhandary, Y. P. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.28033 · Cited by 31
Chronic Obstructive Pulmonary Disease Is Associated with Epigenome-Wide Differential Methylation in BAL Lung Cells
Ström, J. E., Merid, S. K., Pourazar, J., Blomberg, A., Lindberg, A., Ringh, M. V., Hagemann-Jensen, M., Ekström, T. J., Behndig, A., & Melén, E. (2022) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2021-0403oc · Cited by 29
Accelerated lung aging and chronic obstructive pulmonary disease
Yoon, Y.-S., Jin, M., & Sin, D. D. (2019) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2019.1580576 · Cited by 26
Biological pathways and mechanisms linking COPD and cardiovascular disease
Ragnoli, B., Chiazza, F., Tarsi, G., & Malerba, M. (2025) · Therapeutic Advances in Chronic Disease · doi:10.1177/20406223251314286 · Cited by 34
NLRP3 inflammasome mediates abnormal epithelial regeneration and distal lung remodeling in silica‑induced lung fibrosis
Zhou, H., Zhang, Q., Liu, C., Fan, J., Huang, W. T., Li, N., Yang, M., Wang, H., Xie, W., & Kong, H. (2024) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2024.5349 · Cited by 29
Impact of Tongue Pressure and Peak Expiratory Flow Rate on Nutritional Status Of Older Residents of Nursing Homes in Japan: A Cross-Sectional Study
Izumi, M., Sonoki, K., Ohta, Y., Fukuhara, M., Nagata, M., & Akifusa, S. (2020) · The journal of nutrition health & aging · doi:10.1007/s12603-020-1347-y · Cited by 25
p16-3MR: A Novel Model to Study Cellular Senescence in Cigarette Smoke-Induced Lung Injuries
Kaur, G., Sundar, I. K., & Rahman, I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094834 · Cited by 27
Highway to heal: Influence of altered extracellular matrix on infiltrating immune cells during acute and chronic lung diseases
Joglekar, M. M., Nizamoglu, M., Fan, Y., Nemani, S. S. P., Weckmann, M., Pouwels, S. D., Heijink, I. H., Melgert, B. N., Pillay, J., & Burgess, J. K. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.995051 · Cited by 26
Neutrophil phenotypes in chronic lung disease
Hughes, M., Sapey, E., & Stockley, R. A. (2019) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2019.1654377 · Cited by 26
Prevalence and Risk Factors of Chronic Obstructive Pulmonary Disease Among Agriculturists in a Rural Community, Central Thailand
Kitjakrancharoensin, P., Yasan, K., Hongyantarachai, K., Ratanachokthorani, K., Thammasarn, J., Kuwuttiwai, D., Ekanaprach, T., Jittakarm, R., Nuntapravechpun, R., Hotarapavanon, S., et al. (2020) · International Journal of COPD · doi:10.2147/copd.s262050 · Cited by 25
Lung-Targeted Delivery of Dimethyl Fumarate Promotes the Reversal of Age-Dependent Established Lung Fibrosis
Kato, K., Papageorgiou, I., Shin, Y.-J., Kleinhenz, J., Palumbo, S., Hahn, S., Irish, J. D., Rounseville, S. P., Knox, K. S., & Hecker, L. (2022) · Antioxidants · doi:10.3390/antiox11030492 · Cited by 23
Immunosenescence and Inflammation in Chronic Obstructive Pulmonary Disease: A Systematic Review
Jesus, F. R., Passos, F. C., Falcão, M. M. L., Sarno, M., da Silva, I. L. N., Moraes, A. C. S., Neves, M. C. L. C., & Baccan, G. C. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13123449 · Cited by 23
The Role of Manual Therapy in Patients with COPD
Clarke, S., Munro, P. E., & Lee, A. L. (2019) · Healthcare · doi:10.3390/healthcare7010021 · Cited by 25
The lung extracellular matrix protein landscape in severe early-onset and moderate chronic obstructive pulmonary disease
Joglekar, M. M., Bekker, N. J., Ngassie, M. L. K., Vonk, J. M., Borghuis, T., Reinders-Luinge, M., Bakker, J., Woldhuis, R. R., Pouwels, S. D., Melgert, B. N., et al. (2024) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00332.2023 · Cited by 23
Self-citation
The DNA methylation of FOXO3 and TP53 as a blood biomarker of late-onset asthma
Yuan, L., Wang, L., Du, X., Qin, L., Yang, M., Zhou, K., Wu, M., Yang, Y., Zheng, Z., Xiang, Y., et al. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02643-y · Cited by 19
Transcriptomics Analysis Identifies the Decline in the Alveolar Type II Stem Cell Niche in Aged Human Lungs
Liu, X., Zhang, X., Yao, C., Liang, J., Noble, P. W., & Jiang, D. (2024) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2023-0363oc · Cited by 25
Influence of aging on deterioration of patients with COVID-19
Pang, L., Liu, Y., Shen, M., Ye, J., Chen, R., Lan, Z., Wu, Z., Guo, Y., & Zhang, P. (2020) · Aging · doi:10.18632/aging.202136 · Cited by 20
Peptide location fingerprinting identifies species- and tissue-conserved structural remodelling of proteins as a consequence of ageing and disease
Eckersley, A., Ozols, M., Chen, P., Tam, V., Ward, L. J., Hoyland, J. A., Trafford, A. W., Yuan, X., Schiller, H. B., Chan, D. T.-M., et al. (2022) · Matrix Biology · doi:10.1016/j.matbio.2022.05.007 · Cited by 19
Effect of chest wall mobilization on respiratory muscle function in patients with severe chronic obstructive pulmonary disease (COPD): A randomized controlled trial
Tsui, A. Y. Y., Chau, R. M. W., Cheing, G. L. Y., Mok, T., Ling, S. O., Kwan, C. H. Y., & Tsang, S. M. H. (2023) · Respiratory Medicine · doi:10.1016/j.rmed.2023.107436 · Cited by 22
Senolytic drugs in respiratory medicine: is it an appropriate therapeutic approach?
Cazzola, M., Matera, M. G., Rogliani, P., & Calzetta, L. (2018) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2018.1492548 · Cited by 20
Cortex Mori Radicis[Morus Alba L. (Moraceae)] extract alleviates senescence via PI3K/Akt signaling in COPD fibroblasts
Zeng, X., Gao, D.-D., & Zhang, F. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156004 · Cited by 19
Sex Differences in Chronic Obstructive Pulmonary Disease: Implications for Pathogenesis, Diagnosis, and Treatment
Czarnota, P., MacLeod, J. L., Gupta, N., Manichaikul, A. W., & Shim, Y. M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062747 · Cited by 19
The Stress of Lung Aging: Endoplasmic Reticulum and Senescence Tête-à-Tête
Ngassie, M. L. K., Brandsma, C., Gosens, R., Prakash, Y. S., & Burgess, J. K. (2021) · Physiology · doi:10.1152/physiol.00039.2020 · Cited by 20
Self-citation
Small airway disease as a key factor in COPD: new perspectives and insights
Zhou, R., Wang, H., Zhang, Y., Mai, J., & Yang, L. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1648612 · Cited by 17
Targeting accelerated pulmonary ageing to treat chronic obstructive pulmonary disease‐induced neuropathological comorbidities
Luca, S. N. D., & Vlahos, R. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16263 · Cited by 19
The disruptive effects of COPD exacerbation-associated factors on epithelial repair responses
Kortekaas, R. K., Geillinger‐Kästle, K. E., Fuentes‐Mateos, R., van Orsoy, R., Al‐Alyan, N., Burgess, J. K., & Gosens, R. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1346491 · Cited by 17
Transcriptomics in lung tissue upon respiratory syncytial virus infection reveals aging as important modulator of immune activation and matrix maintenance
Pennings, J. L. A., Mariman, R., Hodemaekers, H. M., Reemers, S. S. N., Janssen, R., & Guichelaar, T. (2018) · Scientific Reports · doi:10.1038/s41598-018-35180-2 · Cited by 17
Stabilized Extracellular Vesicle Formulations for Inhalable Dry Powder Development
Jansen, E. M., van der Koog, L., Elferink, R. A. B., Rafie, K., Nagelkerke, A., Gosens, R., Frijlink, H. W., & Hinrichs, W. L. J. (2025) · Small · doi:10.1002/smll.202411096 · Cited by 16
Activation of mTOR signaling in adult lung microvascular progenitor cells accelerates lung aging
Mason, E. C., Menon, S., Schneider, B. R., Gaskill, C. F., Dawson, M. M., Moore, C. M., Armstrong, L. C., Cho, O. J., Richmond, B. W., Kropski, J. A., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci171430 · Cited by 15
Senescence in the lung: is this getting old?
Morty, R. E., & Prakash, Y. S. (2019) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00081.2019 · Cited by 15
Wood smoke exposure affects lung aging, quality of life, and all-cause mortality in New Mexican smokers
Leng, S., Picchi, M. A., Meek, P., Jiang, M., Bayliss, S. H., Zhai, T., Bayliyev, R. I., Tesfaigzi, Y., Campen, M. J., Kang, H., et al. (2022) · Respiratory Research · doi:10.1186/s12931-022-02162-y · Cited by 14
Cell Proliferation and Apoptosis—Key Players in the Lung Aging Process
Áncer‐Rodríguez, J., Gopar‐Cuevas, Y., García‐Aguilar, K., Chávez-Briones, M.-D.-L., Miranda-Maldonado, I. C., Ancer-Arellano, A., Ortega‐Martínez, M., & Jaramillo‐Rangel, G. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147867 · Cited by 16
Diagnostic Challenges and Pathogenetic Differences in Biomass-Smoke-Induced versus Tobacco-Smoke-Induced COPD: A Comparative Review
Dutta, J., Singh, S., Greeshma, M. V., Mahesh, P. A., & Mabalirajan, U. (2024) · Diagnostics · doi:10.3390/diagnostics14192154 · Cited by 19
Predictive Value of the Neutrophil-to-Lymphocyte Ratio/Serum Albumin for All-Cause Mortality in Critically Ill Patients Suffering from COPD
Liu, Y., Zhao, W., Hu, C., Zhang, Y., & Qu, Y.-Q. (2025) · International Journal of COPD · doi:10.2147/copd.s497829 · Cited by 14
Joint association of frailty index and biological age with chronic obstructive pulmonary disease: a cohort study from CHARLS
Ruan, Z., Tian, H., Li, R., Zhang, J., Cao, S., Yang, Z., Chen, X., Li, D., & Miao, Q. (2025) · Scientific Reports · doi:10.1038/s41598-025-99682-6 · Cited by 14
Increased LGR6 Expression Sustains Long-Term Wnt Activation and Acquisition of Senescence in Epithelial Progenitors in Chronic Lung Diseases
Cortesi, E. E., Meeusen, B., Vanstapel, A., Verleden, S. E., Vanaudenaerde, B. M., Wuyts, W. A., Janssens, W., Janssens, V., Roskams, T., & Ventura, J. (2021) · Cells · doi:10.3390/cells10123437 · Cited by 16
The Association of Multiparity with Lung Function and Chronic Obstructive Pulmonary Disease-Related Phenotypes
Moll, M. R., Regan, E. A., Hokanson, J. E., Lutz, S. M., Silverman, E. K., Crapo, J. D., Make, B. J., & DeMeo, D. L. (2020) · Chronic Obstructive Pulmonary Diseases Journal of the COPD Foundation · doi:10.15326/jcopdf.7.2.2019.0166 · Cited by 14
Tenascin-C: Friend or Foe in Lung Aging?
Gremlich, S., Cremona, T. P., Yao, E., Chabenet, F., Fytianos, K., Roth‐Kleiner, M., & Schittny, J. C. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.749776 · Cited by 13
Adipose triglyceride lipase–mediated lipid catabolism is essential for bronchiolar regeneration
Kanti, M. M., Strießnig-Bina, I., Wieser, B. I., Schauer, S., Leitinger, G., Eichmann, T. O., Schweiger, M., Winkler, M., Winter, E., Lana, A., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.149438 · Cited by 12
MicroRNA-377-3p exacerbates chronic obstructive pulmonary disease through suppressing ZFP36L1 expression and inducing lung fibroblast senescence
Lu, F., Yao, L., Gao, D.-D., Alinejad, T., Jiang, X., Wu, Q., Zhai, Q.-C., Liu, M., Zhu, S., Qian, M., et al. (2024) · Respiratory Research · doi:10.1186/s12931-024-02696-3 · Cited by 13
Aging-related changes in the gene expression profile of human lungs
Jeong, I., Lim, J., Park, J., & Oh, Y. (2020) · Aging · doi:10.18632/aging.103885 · Cited by 13
Drosophila Trachea as a Novel Model of COPD
Scholl, A., Ndoja, I., & Jiang, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312730 · Cited by 13
Role and mechanism of WNT5A in benzo(a)pyrene-induced acute lung injury and lung function decline
Fan, L., Wang, B., Ma, J., Ye, Z., Nie, X., Cheng, M., Xie, Y., Gu, P. H., Zhang, Y., You, X., et al. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.132391 · Cited by 12
Underestimation of respiratory symptoms by smokers: a thorn in chronic obstructive pulmonary disease diagnosis
Gogou, E., Kotsiou, O. S., Siachpazidou, D. S., Pinaka, M., Varsamas, C., Bardaka, F., Gerogianni, I., Hatzoglou, C., & Gourgoulianis, K. I. (2021) · npj Primary Care Respiratory Medicine · doi:10.1038/s41533-021-00226-y · Cited by 12
Risk factors for pneumothorax and pulmonary hemorrhage following computed tomography-guided transthoracic core-needle biopsy of subpleural lung lesions
Chiu, J.-H., Chang, Y.-Y., Weng, C.-Y., Lee, Y.-C., Yeh, Y., & Chen, C.-K. (2022) · Journal of the Chinese Medical Association · doi:10.1097/jcma.0000000000000705 · Cited by 11
Aging and lung diseases: Unraveling mechanisms and therapeutic targets
Zhou, Y., Chen, G., Li, X., Li, X., Lin, Z., Liu, L., Pu, D., Chen, J., Chen, Y., Lin, Z., et al. (2025) · Chinese Medical Journal - Pulmonary and Critical Care Medicine · doi:10.1016/j.pccm.2025.11.005 · Cited by 10
Management of Elderly Asthma: Key Questions and Tentative Answers
Park, H., & Cho, S. (2023) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2023.15.1.8 · Cited by 9
Tongue cleaning maintains respiratory function in older individuals: A 1‐year randomised controlled trial
Izumi, M., Sonoki, K., Ohta, Y., Fukuhara, M., Nagata, M., & Akifusa, S. (2021) · Journal of Oral Rehabilitation · doi:10.1111/joor.13165 · Cited by 9
Prevalence and burden of COPD misclassification in the Canadian Longitudinal Study on Aging (CLSA)
Farooqi, M. A., Ma, J., Ali, M. U., Zaman, M., Huang, J. C., Xie, Y., Dragoman, A., Chen, S. J., Raina, P. S., & Duong, M. (2022) · BMJ Open Respiratory Research · doi:10.1136/bmjresp-2021-001156 · Cited by 11
Fibroblast-derived osteoglycin promotes epithelial cell repair
van der Koog, L., Woest, M. E., Gorter, I. C., Verschut, V., Elferink, R. A. B., Zuidhof, A. B., Nugraha, D. F., Ngassie, M. L. K., Bos, S. T., Dhakad, D., et al. (2025) · npj Regenerative Medicine · doi:10.1038/s41536-025-00404-3 · Cited by 9
Self-citation
Relationship between Incidental Abnormalities on Screening Thoracic Computed Tomography and Mortality: A Long-Term Follow-Up Analysis
Lee, J. E., Jeong, W. G., Lee, H., Kim, Y., Chae, K. J., & Jeong, Y. J. (2022) · Korean Journal of Radiology · doi:10.3348/kjr.2022.0131 · Cited by 8
Perspectives of family caregivers and nurses on hospital discharge transitional care for Muslim older adults living with COPD: a qualitative study
Jehloh, L., Songwathana, P., Kitrungrote, L., & Bourbonnais, A. (2024) · BMC Nursing · doi:10.1186/s12912-024-01943-8 · Cited by 8
The impacts of parity on spirometric parameters: a systematic review
Triki, L., & Saad, H. B. (2021) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2021.1935246 · Cited by 8
Ischemic heart disease and chronic obstructive pulmonary disease: the topical problem of comorbidity in internal medicine
Войнаровська, Г. П., & Asanov, E. O. (2020) · ScienceRise Medical Science · doi:10.15587/2519-4798.2020.203968 · Cited by 8
Characteristics of 12-Month Readmission for Hospitalized Patients with COPD: A Propensity Score Matched Analysis of Prospective Multicenter Study
Xu, T., Sun, W., Zhao, H., Wang, X., Yuan, Q., Zhang, X., Mao, S., Zhang, X., Zhao, M., Sheng, Z., et al. (2022) · International Journal of COPD · doi:10.2147/copd.s376909 · Cited by 7
The importance of mechanical forces in chronic respiratory diseases
Burgess, J. K., Nawroth, J. C., Ibáñez‐Fonseca, A., & Gavara, N. (2026) · European Respiratory Review · doi:10.1183/16000617.0155-2025 · Cited by 9
Long-Term Sequelae of Smoking and Cessation in Spontaneously Hypertensive Rats
Wu, C.-W., Yau, T., Fulgar, C. C., Mack, S. M., Revilla, A. M., Kenyon, N. J., & Pinkerton, K. E. (2019) · Toxicologic Pathology · doi:10.1177/0192623319893312 · Cited by 7
Secular Trends of Mortality and Years of Life Lost Due to Chronic Obstructive Pulmonary Disease in Wuhan, China from 2010 to 2019: Age-Period-Cohort Analysis
Guo, Y., Bai, J., Zhang, X., Jin, Q., Liu, Y., & Yu, C. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191710685 · Cited by 6
Evaluation of Risk Factors for Chronic Obstructive Pulmonary Disease in the Middle-Aged and Elderly Rural Population of Northeast China Using Logistic Regression and Principal Component Analysis
Wang, R., Zhang, W., Li, Y., Jiang, Y., Feng, H., Du, Y., Jiao, Z., Li, L., Liu, X., Li, B., et al. (2022) · Risk Management and Healthcare Policy · doi:10.2147/rmhp.s376546 · Cited by 7
Associations of volatile organic compounds with accelerated epigenetic aging in the lungs of smokers and electronic cigarette users
Khan, A., Richardson, C., McElroy, J. P., Singh, A., Weng, D. Y., Kamel, S., Reisinger, S. A., Wewers, M. D., Shields, P. G., & Song, M. (2025) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2025.179792 · Cited by 6
Regenerative therapeutics for chronic obstructive pulmonary disease
van der Koog, L., Showell, H., Nugraha, D. F., Lehmann, M., Conlon, T. M., Yildirim, A. Ö., Fuentes‐Mateos, R., Baarsma, H. A., Ng-Blichfeldt, J.-P., Melgert, B. N., et al. (2026) · Pharmacological Reviews · doi:10.1016/j.pharmr.2026.100124 · Cited by 8

Authors: Brandsma, C.-A., de Vries, M., Costa, R., Woldhuis, R. R., Königshoff, M., & Timens, W.
Affiliations: University Medical Center Groningen (NL)
Helmholtz Munich (DE)
Corresponding author: Brandsma, Corry-Anke
ORCID: Brandsma, Corry-Anke
Costa, Rita
Woldhuis, Roy R.
Timens, Wim
Venue: European Respiratory Review
Publisher: European Respiratory Society (ERS)
Published: 2017-12-06
Volume: 26
Issue: 146
Pages: 170073
ISSN: 0905-9180 (ISSN-L)
1600-0617
DOI: 10.1183/16000617.0073-2017
PMC: PMC9488745
OpenAlex: W2772915294
Cited by: 221
References: 157
Citations by year: 2026: 17 · 2025: 25 · 2024: 29 · 2023: 28 · 2022: 32 · 2021: 34 · 2020: 32 · 2019: 17 · 2018: 7
FWCI: 12.57
Type: journal article
Language: en
Open access: diamond
doi.org
Licence: cc-by-nc
Locations: European Respiratory Review (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Site cant be reached (submittedVersion, cc-by-nc)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Keywords: lung aging, chronic obstructive pulmonary disease, lung remodeling, small airway disease, emphysema, COPD phenotypes, early-onset COPD
MeSH terms: Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Aging, Animals, Child, Female, Gene Expression Regulation, Humans, Lung, Male, Middle Aged, Phenotype, Prognosis, Regeneration, Risk Factors, Cellular Senescence, Pulmonary Disease, Chronic Obstructive, Young Adult, Airway Remodeling

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Lung ageing and COPD: is there a role for ageing in abnormal tissue repair?

Abstract

Overview

Integrity signals

Figures

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks