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Cited by 221Chronic Obstructive Pulmonary Disease (COPD) ResearchAsthma and respiratory diseasesInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

The DOI matches its Crossref record; 157 of the 157 references it cites were found in a registry or an index.

Lung ageing and COPD: is there a role for ageing in abnormal tissue repair?

Open access
Brandsma, Corry-Anke, de Vries, Maaike, Costa, Rita, Woldhuis, Roy R., Königshoff, Melanie, Timens, Wim·2017·European Respiratory Review
DOI 10.1183/16000617.0073-2017PMC PMC9488745
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Abstract

Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide, with increasing prevalence, in particular in the elderly. COPD is characterised by abnormal tissue repair resulting in (small) airways disease and emphysema. There is accumulating evidence that ageing hallmarks are prominent features of COPD. These ageing hallmarks have been described in different subsets of COPD patients, in different lung compartments and also in a variety of cell types, and thus might contribute to different COPD phenotypes. A better understanding of the main differences and similarities between normal lung ageing and the pathology of COPD may improve our understanding of the mechanisms driving COPD pathology, in particular in those patients that develop the most severe form of COPD at a relatively young age, i.e. severe early-onset COPD patients. In this review, after introducing the main concepts of lung ageing and COPD pathology, we focus on the role of (abnormal) ageing in lung remodelling and repair in COPD. We discuss the current evidence for the involvement of ageing hallmarks in these pathological features of COPD. We also highlight potential novel treatment strategies and opportunities for future research based on our current knowledge of abnormal lung ageing in COPD.

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FIGURE 1 Pathological changes in chronic obstructive pulmonary disease. a) Characteristic picture of airways changes, with increase of goblet cells, a thickened airway wall with some adventitial inflammation, and a small lymphoid follicle at the left upper side. Emphysema is hardly present here. Haematoxylin and eosin, ×200 magnification, scale bar=200 μm. Inset shows magnification of part of the airway with a lymphoid follicle; scale bar=50 μm. b) At the left, an almost longitudinal cross-section of a small airway, and at the right, severe parenchymal destruction by emphysema. Haematoxylin and eosin, ×100 magnification, scale bar=500 μm.
FIGURE 1 Pathological changes in chronic obstructive pulmonary disease. a) Characteristic picture of airways changes, with increase of goblet cells, a thickened airway wall with some adventitial inflammation, and a small lymphoid follicle at the left upper side. Emphysema is hardly present here. Haematoxylin and eosin, ×200 magnification, scale bar=200 μm. Inset shows magnification of part of the airway with a lymphoid follicle; scale bar=50 μm. b) At the left, an almost longitudinal cross-section of a small airway, and at the right, severe parenchymal destruction by emphysema. Haematoxylin and eosin, ×100 magnification, scale bar=500 μm.CC BY-NC · PubMed Central

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  1. 10.1146/annurev.pathol.4.110807.092145 · DOI

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Metadata

Authors
Brandsma, C.-A., de Vries, M., Costa, R., Woldhuis, R. R., Königshoff, M., & Timens, W.
Affiliations
  • University Medical Center Groningen (NL)
  • Helmholtz Munich (DE)
Corresponding author
Brandsma, Corry-Anke
ORCID
Venue
European Respiratory Review
Publisher
European Respiratory Society (ERS)
Published
2017-12-06
Volume
26
Issue
146
Pages
170073
ISSN
  • 0905-9180 (ISSN-L)
  • 1600-0617
DOI
10.1183/16000617.0073-2017
PMC
PMC9488745
OpenAlex
W2772915294
Cited by
221
References
157
Citations by year
2026: 17 · 2025: 25 · 2024: 29 · 2023: 28 · 2022: 32 · 2021: 34 · 2020: 32 · 2019: 17 · 2018: 7
FWCI
12.57
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • European Respiratory Review (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Site cant be reached (submittedVersion, cc-by-nc)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
  • PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Keywords
lung aging, chronic obstructive pulmonary disease, lung remodeling, small airway disease, emphysema, COPD phenotypes, early-onset COPD
MeSH terms
Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Aging, Animals, Child, Female, Gene Expression Regulation, Humans, Lung, Male, Middle Aged, Phenotype, Prognosis, Regeneration, Risk Factors, Cellular Senescence, Pulmonary Disease, Chronic Obstructive, Young Adult, Airway Remodeling

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