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High efficient isolation and systematic identification of human adipose-derived mesenchymal stem cells
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BACKGROUND: Developing efficient methods to isolate and identify human adipose-derived mesenchymal stem cells (hADSCs) remains to be one of the major challenges in tissue engineering. METHODS: We demonstrate here a method by isolating hADSCs from abdominal subcutaneous adipose tissue harvested during caesarian section. The hADSCs were isolated from human adipose tissue by collagenase digestion and adherence to flasks. RESULTS: The yield reached around 1 × 10(6) hADSCs per gram adipose tissue. The following comprehensive identification and characterization illustrated pronounced features of mesenchymal stem cells (MSCs). The fibroblast-like hADSCs exhibited typical ultrastructure details for vigorous cell activities. Karyotype mapping showed normal human chromosome. With unique immunophenotypes they were positive for CD29, CD44, CD73, CD105 and CD166, but negative for CD31, CD34, CD45 and HLA-DR. The growth curve and cell cycle analysis revealed high capability for self-renewal and proliferation. Moreover, these cells could be functionally induced into adipocytes, osteoblasts, and endothelial cells in the presence of appropriate conditioned media. CONCLUSION: The data presented here suggest that we have developed high efficient isolation and cultivation methods with a systematic strategy for identification and characterization of hADSCs. These techniques will be able to provide safe and stable seeding cells for research and clinical application.
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hADSCs possess differentiation capacities and MSC-specific phenotypes.
“These findings confirmed differentiation capacities and phenotypes of hADSCs, in agreement with the literature [41].”
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Running Title: Mesenchymal Stem Cells originated from fragmented fat
Carelli, S., Messaggio, F., Canazza, A., Hebda, D. M., Caremoli, F., Latorre, E., Grimoldi, M. G., Colli, M., Bulfamante, G., Tremolada, C., et al. (2014)
Metadata
- Authors
- Yang, X.-F., He, X., He, J., Zhang, L.-H., Su, X.-J., Dong, Z.-Y., Xu, Y.-J., Li, Y., & Li, Y.-L.
- Affiliations
- Jilin University (CN)
- Corresponding author
- He, Xu
- Li, Yan
- Venue
- Journal of Biomedical Science
- Published
- 2011-08-19
- Volume
- 18
- Issue
- 1
- Pages
- 59-59
- ISSN
- 1021-7770 (ISSN-L)
- 1423-0127
- PMC
- PMC3175156
- OpenAlex
- W2087905124
- Cited by
- 112
- References
- 25
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 1 · 2023: 2 · 2022: 7 · 2021: 7 · 2020: 8 · 2019: 6 · 2018: 17 · 2017: 9 · 2016: 9 · 2015: 12 · 2014: 8 · 2013: 15 · 2012: 4
- FWCI
- 4.37
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Journal of Biomedical Science (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Natural Science Foundation of China (863 Program)
- National High-tech Research and Development Program
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Keywords
- human adipose-derived mesenchymal stem cells, adipose tissue harvesting, collagenase digestion, cell isolation, immunophenotyping, cell cycle analysis, self-renewal, multilineage differentiation, adipogenesis, bone formation, endothelial differentiation, karyotype
- MeSH terms
- Adult, Cell Cycle, Cell Differentiation, Cell Separation, Female, Humans, Immunohistochemistry, Karyotyping, Immunophenotyping, Collagenases, Fluorescent Antibody Technique, Indirect, Tissue Engineering, Microscopy, Electron, Transmission, Cell Proliferation, Subcutaneous Fat, Mesenchymal Stem Cells, Real-Time Polymerase Chain Reaction
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