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Cited by 1,157Chronic Obstructive Pulmonary Disease (COPD) ResearchAsthma and respiratory diseasesSmoking Behavior and Cessation

The DOI matches its Crossref record; 30 of the 32 references it cites were found in a registry or an index.

Characterisation of COPD heterogeneity in the ECLIPSE cohort

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the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) investigators, Agusti, Alvar, Calverley, Peter MA, Celli, Bartolome, Coxson, Harvey O, Edwards, Lisa D, Lomas, David A, MacNee, William, Miller, Bruce E, Rennard, Steve, Silverman, Edwin K, Tal-Singer, Ruth, Wouters, Emiel, Yates, Julie C, Vestbo, Jørgen·2010·Respiratory Research
DOI 10.1186/1465-9921-11-122PMC PMC2944278
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Abstract

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a complex condition with pulmonary and extra-pulmonary manifestations. This study describes the heterogeneity of COPD in a large and well characterised and controlled COPD cohort (ECLIPSE). METHODS: We studied 2164 clinically stable COPD patients, 337 smokers with normal lung function and 245 never smokers. In these individuals, we measured clinical parameters, nutritional status, spirometry, exercise tolerance, and amount of emphysema by computed tomography. RESULTS: COPD patients were slightly older than controls and had more pack years of smoking than smokers with normal lung function. Co-morbidities were more prevalent in COPD patients than in controls, and occurred to the same extent irrespective of the GOLD stage. The severity of airflow limitation in COPD patients was poorly related to the degree of breathlessness, health status, presence of co-morbidity, exercise capacity and number of exacerbations reported in the year before the study. The distribution of these variables within each GOLD stage was wide. Even in subjects with severe airflow obstruction, a substantial proportion did not report symptoms, exacerbations or exercise limitation. The amount of emphysema increased with GOLD severity. The prevalence of bronchiectasis was low (4%) but also increased with GOLD stage. Some gender differences were also identified. CONCLUSIONS: The clinical manifestations of COPD are highly variable and the degree of airflow limitation does not capture the heterogeneity of the disease.

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Crossref · 10.1186/1465-9921-11-122

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Figures

Figure 1 Consort diagram.
Figure 1 Consort diagram.CC BY · PubMed Central
Figure 2 Variability of age (panel A), gender (panel B), smoking status (panel C) and FEV1 (panel D) in the three groups of individuals recruited into ECLIPSE by the 46 participating centres.
Figure 2 Variability of age (panel A), gender (panel B), smoking status (panel C) and FEV1 (panel D) in the three groups of individuals recruited into ECLIPSE by the 46 participating centres.CC BY · PubMed Central
Figure 3 Relationship between age (panel A) and cumulative smoking exposure (panel B) at entry into the study and degree of airflow limitation in patients with COPD. For further explanations see text.
Figure 3 Relationship between age (panel A) and cumulative smoking exposure (panel B) at entry into the study and degree of airflow limitation in patients with COPD. For further explanations see text.CC BY · PubMed Central
Figure 4 Frequency distribution of the breathlessness as assessed by the mMRC questionnaire (panel A), exercise capacity as assessed by the 6MWD (panel B), reported exacerbations in the year before inclusion in the study (panel C), and health status assessed by SGRQ-C (panel D) according to severity of disease. For further explanations see text.
Figure 4 Frequency distribution of the breathlessness as assessed by the mMRC questionnaire (panel A), exercise capacity as assessed by the 6MWD (panel B), reported exacerbations in the year before inclusion in the study (panel C), and health status assessed by SGRQ-C (panel D) according to severity of disease. For further explanations see text.CC BY · PubMed Central
Figure 5 Relationship between the severity of airflow limitation and breathlessness as assessed by the mMRC questionnaire (panel A), exercise capacity as assessed by the 6MWD (panel B), reported exacerbations in the year before inclusion in the study (panel C), and health status as assessed by SGRQ-C (panel D). For further explanations see text.
Figure 5 Relationship between the severity of airflow limitation and breathlessness as assessed by the mMRC questionnaire (panel A), exercise capacity as assessed by the 6MWD (panel B), reported exacerbations in the year before inclusion in the study (panel C), and health status as assessed by SGRQ-C (panel D). For further explanations see text.CC BY · PubMed Central

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Authors
the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) investigators, Agusti, A., Calverley, P. M., Celli, B., Coxson, H. O., Edwards, L. D., Lomas, D. A., MacNee, W., Miller, B. E., Rennard, S., Silverman, E. K., Tal-Singer, R., Wouters, E., Yates, J. C., & Vestbo, J.
Affiliations
  • Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (ES)
  • Brigham and Women's Hospital (US)
  • University of British Columbia (CA)
  • University of Cambridge (GB)
  • Edinburgh Royal Infirmary (GB)
  • GlaxoSmithKline (United States) (US)
  • Maastricht University Medical Centre (NL)
  • University of Copenhagen (DK)
ORCID
Venue
Respiratory Research
Publisher
Springer Science and Business Media LLC
Published
2010-09-10
Volume
11
Issue
1
Pages
122-122
ISSN
  • 1465-9921 (ISSN-L)
  • 1465-993X
DOI
10.1186/1465-9921-11-122
PMC
PMC2944278
OpenAlex
W2142096203
Semantic Scholar
40fa41938c0c969c1ab6219b857fcd884f7a804b
Cited by
1,157
References
32
Citations by year
2026: 24 · 2025: 32 · 2024: 51 · 2023: 39 · 2022: 50 · 2021: 83 · 2020: 91 · 2019: 73 · 2018: 94 · 2017: 101 · 2016: 96 · 2015: 103 · 2014: 104 · 2013: 90 · 2012: 67
FWCI
57.14
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Respiratory Research (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research Publications (Maastricht University) (publishedVersion, cc-by)
  • Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (publishedVersion, cc-by)
  • RECERCAT (Consorci de Serveis Universitaris de Catalunya) (publishedVersion, other-oa)
  • DigitalCommons@UNMC (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • UCL Discovery (University College London) (submittedVersion)
  • Research Explorer (The University of Manchester) (submittedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
  • Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by)
  • Apollo (University of Cambridge) (submittedVersion, cc-by)
  • Research Publications (Maastricht University) (submittedVersion, other-oa)
Funders
GlaxoSmithKline
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Keywords
chronic obstructive pulmonary disease, disease heterogeneity, ECLIPSE cohort, GOLD severity, airflow obstruction, dyspnea, comorbidities, exacerbations, exercise capacity, emphysema, bronchiectasis, nutritional status, smoking, never smokers, sex differences
MeSH terms
Adult, Aged, Cross-Sectional Studies, Female, Humans, Longitudinal Studies, Male, Middle Aged, Respiratory Function Tests, Smoking, Cohort Studies, Pulmonary Disease, Chronic Obstructive

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