Rhinovirus infection induces cytotoxicity and delays wound healing in bronchial epithelial cells
Open accessAbstract
Background: Human rhinoviruses (RV), the most common triggers of acute asthma exacerbations, are considered not cytotoxic to the bronchial epithelium. Recent observations, however, have questioned this knowledge. The aim of this study was to evaluate the ability of RV to induce epithelial cytotoxicity and affect epithelial repair in-vitro. Methods: Monolayers of BEAS-2B bronchial epithelial cells, seeded at different densities were exposed to RV serotypes 1b, 5, 7, 9, 14, 16. Cytotoxicity was assessed chromatometrically. Epithelial monolayers were mechanically wounded, exposed or not to RV and the repopulation of the damaged area was assessed by image analysis. Finally epithelial cell proliferation was assessed by quantitation of proliferating cell nuclear antigen (PCNA) by flow cytometry. Results: RV1b, RV5, RV7, RV14 and RV16 were able to induce considerable epithelial cytotoxicity, more pronounced in less dense cultures, in a cell-density and dose-dependent manner. RV9 was not cytotoxic. Furthermore, RV infection diminished the self-repair capacity of bronchial epithelial cells and reduced cell proliferation. Conclusion: RV-induced epithelial cytotoxicity may become considerable in already compromised epithelium, such as in the case of asthma. The RV-induced impairment on epithelial proliferation and self-repair capacity may contribute to the development of airway remodeling.
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Rhinoviruses have been shown to be major regulators of airway remodeling processes, involving not only the airway epithelium but also other components of the airway mucosa.
“Rhinoviruses have been shown to be major regulators of such airway remodeling processes, involving not only the airway epithelium but also other components of the airway mucosa.”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [27]
Rhinoviruses are capable of delaying wound healing in bronchial epithelial cells.
“They are capable of delaying wound healing in bronchial epithelial cells (27).”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [27]
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Cites
Community study of role of viral infections in exacerbations of asthma in 9–11 year old children
Johnston, S. L., Pattemore, P. K., Sanderson, G., Smith, S., Lampe, F., Josephs, L., Symington, P., Toole, S. O., Myint, S. H., Tyrrell, D. A. J., et al. (1995) · BMJ · doi:10.1136/bmj.310.6989.1225 · Cited by 1,991 · see citing works
Asthma: From Bronchoconstriction to Airways Inflammation and Remodeling
BOUSQUET, J., JEFFERY, P. K., BUSSE, W. W., JOHNSON, M., & VIGNOLA, A. M. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.5.9903102 · Cited by 1,702 · see citing works
Wark, P. A. B., Johnston, S. L., Bucchieri, F., Powell, R., Puddicombe, S. M., Laza‐Stanca, V., Holgate, S. T., & Davies, D. E. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041901 · Cited by 1,235 · see citing works
Corne, J. M., Marshall, C., Smith, S. H., Schreiber, J., Sanderson, G., Holgate, S. T., & Johnston, S. L. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07953-9 · Cited by 571 · see citing works
Rhinoviruses infect the lower airways
Papadopoulos, N. G., Bates, P. J., Bardin, P. G., Papi, A., Leir, S. H., Fraenkel, D. J., Meyer, J., Lackie, P. M., Sanderson, G., Holgate, S. T., et al. (2000) · The Journal of Infectious Diseases · doi:10.1086/315513 · Cited by 535 · see citing works
Self-citationInvolvement of the epidermal growth factor receptor in epithelial repair in asthma
Puddicombe, S. M. (2000) · The FASEB Journal · doi:10.1096/fj.14.10.1362 · Cited by 498 · see citing works
Airway remodeling in asthma: New insights
Nelson, H. S., Davies, D. E., Wicks, J., Powell, R. M., Puddicombe, S. M., & Holgate, S. T. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2003.128 · Cited by 482 · see citing works
Lower Airways Inflammation during Rhinovirus Colds in Normal and in Asthmatic Subjects
Fraenkel, D. J., Bardin, P. G., Sanderson, G., Lampe, F. C., Johnston, S. L., & Holgate, S. T. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm/151.3_pt_1.879 · Cited by 387 · see citing works
Subauste, M. C., Jacoby, D. B., Richards, S. M., & Proud, D. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118067 · Cited by 385 · see citing works
Human airway epithelial cells produce IP-10 (CXCL10) in vitro and in vivo upon rhinovirus infection
Spurrell, J. C. L., Wiehler, S., Zaheer, R. S., Sanders, S. P., & Proud, D. (2005) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00397.2004 · Cited by 282 · see citing works
Virus-induced Airway Hyperresponsiveness and Asthma
Folkerts, G., Busse, W. W., Nijkamp, F. P., Sorkness, R. L., & Gern, J. E. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.6.9707163 · Cited by 264 · see citing works
Rhinovirus Replication Causes RANTES Production in Primary Bronchial Epithelial Cells
Schroth, M. K., Grimm, E., Frindt, P., Galagan, D. M., Konno, S.-I., Love, R. B., & Gern, J. E. (1999) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.20.6.3261 · Cited by 223 · see citing works
Quantitative and Qualitative Analysis of Rhinovirus Infection in Bronchial Tissues
Mosser, A. G., Vrtis, R. F., Burchell, L., Lee, W.-M., Dick, C. R., Weisshaar, E., Bock, D., Swenson, C. A., Cornwell, R. D., Meyer, K. C., et al. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200407-970oc · Cited by 220 · see citing works
Rhinoviruses replicate effectively at lower airway temperatures
Papadopoulos, N. G., Sanderson, G., Hunter, J., & Johnston, S. L. (1999) · Journal of Medical Virology · doi:10.1002/(sici)1096-9071(199905)58:1 · Cited by 212 · see citing works
Self-citationSites of rhinovirus recovery after point inoculation of the upper airway
Winther, B. (1986) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1986.03380130091034 · Cited by 178 · see citing works
Salmeron, S., LIARD, R., Elkharrat, D., Muir, J., Neukirch, F., & Ellrodt, A. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05779-8 · Cited by 170 · see citing works
Conaldi, P. G., Biancone, L., Bottelli, A., Wade-Evans, A. M., Racusen, L. C., Boccellino, M., Orlandi, V. T., Serra, C., Camussi, G., & Toniolo, A. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3480 · Cited by 153 · see citing works
Fas and tumor necrosis factor receptor-mediated cell death: similarities and distinctions.
Clement, M., & Stamenkovic, I. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.2.557 · Cited by 142 · see citing works
Erjefalt, J. S., Greiff, L., Andersson, M., MATSSON, E., Petersen, H., Linden, M., Ansari, T. W., Jeffery, P. K., & Persson, C. G. A. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.1.9809048 · Cited by 137 · see citing works
Double-Stranded RNA Induces the Synthesis of Specific Chemokines by Bronchial Epithelial Cells
Gern, J. E., French, D. A., Grindle, K. A., Brockman-Schneider, R. A., Konno, S.-I., & Busse, W. W. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2002-0055oc · Cited by 130 · see citing works
Increased Expression of p21waf Cyclin-Dependent Kinase Inhibitor in Asthmatic Bronchial Epithelium
Puddicombe, S. M., Torres-Lozano, C., Richter, A., Bucchieri, F., Lordan, J. L., Howarth, P. H., Vrugt, B., Albers, R., Djukanović, R., Holgate, S. T., et al. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.4715 · Cited by 130 · see citing works
Gibson, P. G., SALTOS, N., & Borgas, T. (2000) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2000.105319 · Cited by 127 · see citing works
Respiratory Virus Infection of Monolayer Cultures of Human Nasal Epithelial Cells
Winther, B., Gwaltney, J. M., & Hendley, J. O. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/141.4_pt_1.839 · Cited by 124 · see citing works
Rhinovirus infection up‐regulates eotaxin and eotaxin‐2 expression in bronchial epithelial cells
Papadopoulos, N. G., Papi, A. A., Meyer, J., Stanciu, L. A., Salvi, S., Holgate, S. T., & Johnston, S. L. (2001) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2001.01112.x · Cited by 123 · see citing works
Self-citationHoltzman, M. J., Morton, J. D., Shornick, L. P., Tyner, J. W., O’Sullivan, M. P., Antao, A. B., Lo, M. S., Castro, M., & Walter, M. J. (2002) · Physiological Reviews · doi:10.1152/physrev.00020.2001 · Cited by 123 · see citing works
Epithelial cells and fibroblasts: structural repair and remodelling in the airways
Sacco, O., Silvestri, M., Sabatini, F., Sale, R., Defilippi, A., & Rossi, G. A. (2004) · Paediatric Respiratory Reviews · doi:10.1016/s1526-0542(04)90008-5 · Cited by 115 · see citing works
Resistance of differentiated human airway epithelium to infection by rhinovirus
Lopez-Souza, N., Dolganov, G., Dubin, R. F., Sachs, L. A., Sassina, L., Sporer, H., Yagi, S., Schnurr, D. P., Boushey, H. A., & Widdicombe, J. H. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00300.2003 · Cited by 108 · see citing works
Trefoil Factor Family–Peptides Promote Migration of Human Bronchial Epithelial Cells
Oertel, M., Graneß, A., Thim, L., Bühling, F., Kalbacher, H., & Hoffmann, W. (2001) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.25.4.4429 · Cited by 97 · see citing works
Proliferation and activation of bronchial epithelial cells in corticosteroid-dependent asthma
Vignola, A. M., Chiappara, G., Siena, L., Bruno, A., Gagliardo, R. P., Merendino, A. M., Polla, B. S., Arrigo, A., Bonsignore, G., Bousquet, J. J., et al. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.119160 · Cited by 84 · see citing works
Zeymer, U., Fishbein, M. C., Forrester, J. S., & Cercek, B. (1992) · PubMed Central · Cited by 74 · see citing works
Donninger, H., Glashoff, R. H., Haitchi, H. M., Syce, J. A., Ghildyal, R., van Rensburg, E. J., & Bardin, P. G. (2003) · The Journal of Infectious Diseases · doi:10.1086/375246 · Cited by 69 · see citing works
Immunohistochemical Analysis of Nasal Biopsies During Rhinovirus Experimental Colds
Fraenkel, D. J., Bardin, P. G., Sanderson, G., Lampe, F. C., Johnston, S. L., & Holgate, S. T. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.150.4.7921447 · Cited by 52 · see citing works
Apoptotic events induced by human rhinovirus infection
Deszcz, L., Gaudernak, E., Kuechler, E., & Seipelt, J. (2005) · Journal of General Virology · doi:10.1099/vir.0.80754-0 · Cited by 52 · see citing works
Hewitt, C. R. A., Horton, H., Jones, R. M. H., & PRITCHARD, D. I. (1997) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.1997.tb00694.x · Cited by 51 · see citing works
Yamaya, M., & Sasaki, H. (2003) · Viral Immunology · doi:10.1089/088282403322017857 · Cited by 44 · see citing works
Yamaya, M., Sekizawa, K., Suzuki, T., Yamada, N., Furukawa, M., Ishizuka, S., Nakayama, K., Terajima, M., Numazaki, Y., & Sasaki, H. (1999) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1999.277.2.l362 · Cited by 40 · see citing works
Woltmann, G., Ward, R. J., Symon, F. A., Rew, D. A., Pavord, I. D., & Wardlaw, A. J. (1999) · Thorax · doi:10.1136/thx.54.2.124 · Cited by 31 · see citing works
Takami, K., Takuwa, N., Okazaki, H., Kobayashi, M., Ohtoshi, T., Kawasaki, S., Dohi, M., Yamamoto, K., Nakamura, T., Tanaka, M., et al. (2002) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.26.2.4643 · Cited by 30 · see citing works
The role of respiratory viruses in the origin and exacerbations of asthma
Papadopoulos, N. G., Psarras, S., Manoussakis, E., & Saxoni‐Papageorgiou, P. (2003) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/00130832-200302000-00007 · Cited by 27 · see citing works
Self-citationBiosynthesized matrix provides a key role for survival signaling in bronchial epithelial cells
Wadsworth, S. J., Freyer, A. M., Corteling, R. L., & Hall, I. P. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00217.2003 · Cited by 26 · see citing works
Sites of rhinovirus recovery after point inoculation of the upper airway
Winther, B. (1986) · JAMA · doi:10.1001/jama.256.13.1763 · Cited by 22 · see citing works
Role of carbohydrates in repair of human respiratory epithelium using an in vitro model
Adam, E. C., Holgate, S. T., Fildew, C. J., & Lackie, P. M. (2003) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2003.01771.x · Cited by 14 · see citing works
Papadopoulos, N. G., Syrigou, E. I., Bossios, A., Manou, O., Gourgiotis, D., & Saxoni‐Papageorgiou, P. (1999) · International Archives of Allergy and Immunology · doi:10.1159/000024177 · Cited by 8 · see citing works
Self-citationXatzipsalti, M. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.12.710 · Cited by 2 · see citing works
Hewitt, C. R. A., HORTON, H., JONES, R. M., et al. (1997) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.1997.d01-492.x · Cited by 2 · see citing works
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Respiratory Viral Infections in Infants: Causes, Clinical Symptoms, Virology, and Immunology
Tregoning, J. S., & Schwarze, J. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00032-09 · Cited by 746 · see citing works
The airway epithelium: soldier in the fight against respiratory viruses
Vareille, M., Kieninger, E., Edwards, M. R., & Regamey, N. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-10 · Cited by 655 · see citing works
Edwards, M. R., Bartlett, N. W., Hussell, T., Openshaw, P., & Johnston, S. L. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2801 · Cited by 205 · see citing works
The role of viral infections in exacerbations of chronic obstructive pulmonary disease and asthma
Hewitt, R., Farne, H. A., Ritchie, A. I., Luke, E., Johnston, S. L., & Mallia, P. (2015) · Therapeutic Advances in Respiratory Disease · doi:10.1177/1753465815618113 · Cited by 185 · see citing works
Basal Cells of Differentiated Bronchial Epithelium Are More Susceptible to Rhinovirus Infection
Jakieła, B., Brockman‐Schneider, R. A., Amineva, S. P., Lee, W.-M., & Gern, J. E. (2007) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2007-0050oc · Cited by 163 · see citing works
A Microengineered Airway Lung Chip Models Key Features of Viral-induced Exacerbation of Asthma
Nawroth, J. C., Lucchesi, C., Cheng, D., Shukla, A., Ngyuen, J., Shroff, T., Varone, A., Karalis, K., Lee, H., Alves, S. E., et al. (2020) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2020-0010ma · Cited by 129 · see citing works
Rossi, G. A., & Colin, A. A. (2014) · European Respiratory Journal · doi:10.1183/09031936.00062714 · Cited by 123 · see citing works
Understanding the mechanisms of viral induced asthma: New therapeutic directions
Hansbro, N. G., Horvat, J. C., Wark, P. A. B., & Hansbro, P. M. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.11.002 · Cited by 120 · see citing works
Cakebread, J. A., Xu, Y., Grainge, C., Kehagia, V., Howarth, P. H., Holgate, S. T., & Davies, D. E. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.01.023 · Cited by 115 · see citing works
Innate Inflammatory Responses of Pediatric Cystic Fibrosis Airway Epithelial Cells
Sutanto, E. N., Kicic, A., Foo, C. J., Stevens, P. T., Mullane, D., Knight, D. A., & Stick, S. M. (2011) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2010-0368oc · Cited by 98 · see citing works
Nagarkar, D. R., Wang, Q., Shim, J., Zhao, Y., Tsai, W. C., Lukacs, N. W., Sajjan, U. S., & Hershenson, M. B. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900298 · Cited by 90 · see citing works
Papadopoulos, N. G., Xepapadaki, P. V., Mallia, P., Brusselle, G., Watelet, J. B., Xatzipsalti, M., Foteinos, G., van Drunen, C. M., Fokkens, W. J., D’Ambrosio, C., et al. (2007) · Allergy · doi:10.1111/j.1398-9995.2007.01341.x · Cited by 90 · see citing works
Self-citationPathogenesis of Viral Infection in Exacerbations of Airway Disease
Ritchie, A. I., Farne, H. A., Singanayagam, A., Jackson, D. J., Mallia, P., & Johnston, S. L. (2015) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201503-151aw · Cited by 89 · see citing works
Rhinoviruses, allergic inflammation, and asthma
Gavala, M. L., Bertics, P. J., & Gern, J. E. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01031.x · Cited by 87 · see citing works
A Current Perspective of Allergic Asthma: From Mechanisms to Management
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Self-citationActivation of Toll-Like Receptor 3 Augments Myofibroblast Differentiation
Sugiura, H., Ichikawa, T., Koarai, A., Yanagisawa, S., Minakata, Y., Matsunaga, K., Hirano, T., Akamatsu, K., & Ichinose, M. (2008) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0371oc · Cited by 71 · see citing works
Innate immune response to viral infection of the lungs
See, H. V., & Wark, P. A. B. (2008) · Paediatric Respiratory Reviews · doi:10.1016/j.prrv.2008.04.001 · Cited by 70 · see citing works
The Microbiome and the Pathophysiology of Asthma
Sullivan, A., Hunt, E. B., MacSharry, J. A., & Murphy, D. M. (2016) · Respiratory Research · doi:10.1186/s12931-016-0479-4 · Cited by 65 · see citing works
Viral-associated exacerbations of asthma and COPD
Traves, S. L., & Proud, D. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2006.11.010 · Cited by 57 · see citing works
Modulation of the epithelial inflammatory response to rhinovirus in an atopic environment
Xatzipsalti, M., Psarros, F., Konstantinou, G. Ν., Gaga, M., Gourgiotis, D., Saxoni‐Papageorgiou, P., & Papadopoulos, N. G. (2007) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2007.02906.x · Cited by 54 · see citing works
Self-citationRhinovirus-Induced Exacerbations of Asthma and COPD
Hershenson, M. B. (2013) · Scientifica · doi:10.1155/2013/405876 · Cited by 54 · see citing works
Bossios, A., Gourgiotis, D., Skevaki, C. L., Saxoni‐Papageorgiou, P., Lötvall, J. O., Psarras, S., Karpathios, T., Constandopoulos, A. G., Johnston, S. L., & Papadopoulos, N. G. (2008) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2008.03058.x · Cited by 49 · see citing works
Self-citationRhinoviruses in the pathogenesis of asthma: The bronchial epithelium as a major disease target
Holgate, S. T. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.06.023 · Cited by 48 · see citing works
Novak, N., & Cabanillas, B. (2020) · Immunology · doi:10.1111/imm.13240 · Cited by 47 · see citing works
Childhood asthma and infection: virus-induced exacerbations as determinants and modifiers: Figure 1–
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Self-citationHow does rhinovirus cause the common cold cough?
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Rhinovirus‐induced basic fibroblast growth factor release mediates airway remodeling features
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Zhu, Q., Hu, H., Liu, H., Shen, H. C., Yan, Z., & Gao, L. (2020) · Antiviral Research · doi:10.1016/j.antiviral.2020.104933 · Cited by 39 · see citing works
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Vlachou, F. J., Varela, A., Σταθοπούλου, Κ., Ntatsoulis, K., Synolaki, E., Pratsinis, H., Kletsas, D., Sideras, P., Davos, C. H., Capetanaki, Y., et al. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04266-6 · Cited by 38 · see citing works
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RSV attenuates epithelial cell restitution by inhibiting actin cytoskeleton-dependent cell migration
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Self-citationHashimoto, S., Matsumoto, K., Gon, Y., Ichiwata, T., Takahashi, N., & Kobayashi, T. (2008) · Allergology International · doi:10.2332/allergolint.r-07-156 · Cited by 27 · see citing works
Bacteria and viruses and their role in the preschool wheeze to asthma transition
Papadopoulos, N. G., Apostolidou, E., Miligkos, M., & Xepapadaki, P. V. (2024) · Pediatric Allergy and Immunology · doi:10.1111/pai.14098 · Cited by 25 · see citing works
Self-citationIL-13 suppresses double-stranded RNA-induced IFN-λ production in lung cells
Moriwaki, A., Matsumoto, K., Matsunaga, Y., Fukuyama, S., Matsumoto, T., Kan‐o, K., Noda, N., Asai, Y., Nakanishi, Y., & Inoue, H. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.12.082 · Cited by 25 · see citing works
Distinction between rhinovirus‐induced acute asthma and asthma‐augmented influenza infection
Guibas, G. V., Tsolia, M. N., Christodoulou, I., Stripeli, F., Sakkou, Z., & Papadopoulos, N. G. (2018) · Clinical & Experimental Allergy · doi:10.1111/cea.13124 · Cited by 21 · see citing works
Self-citationChen, F., Zhao, Y., Yuan, C., Lü, D., Wang, S., Sun, Z., & Hu, H. (2025) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2025.06.023 · Cited by 20 · see citing works
Microbiome-focused asthma management strategies
Shukla, S. D., Shastri, M. D., Chong, W. C., Dua, K., Budden, K. F., Mahmood, M. Q., Hansbro, N. G., Keely, S., Eri, R. D., Patel, R. P., et al. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.06.003 · Cited by 20 · see citing works
Wang, X., Mychajlowycz, M., Lau, C., Gutierrez, C., Scott, J. A., & Chow, C. (2011) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.111.186429 · Cited by 20 · see citing works
Montgomery, S., Frey, D. L., Mall, M. A., Stick, S. M., Kicic, A., & CF, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00596 · Cited by 19 · see citing works
Prazma, C. M., Kral, K. M., Gul, N., Yancey, S. W., & Stempel, D. A. (2010) · Respiratory Medicine · doi:10.1016/j.rmed.2010.02.007 · Cited by 18 · see citing works
Tay, C. J. X., Ta, L. D. H., Yeong, Y. X. O., Yap, G. C., Chu, J. J. H., Lee, B. W., & Tham, E. H. (2021) · International Archives of Allergy and Immunology · doi:10.1159/000513325 · Cited by 17 · see citing works
Chen, T., Pei, Y., Zhang, L., & Zhang, Y. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.136300 · Cited by 14 · see citing works
Johnson‐Weaver, B. T., Choi, H. W., Yang, H., Granek, J. A., Chan, C. C. W., Abraham, S. N., & Staats, H. F. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.730346 · Cited by 13 · see citing works
Curcumin modulates airway remodelling‐contributing genes—the significance of transcription factors
Wieczfińska, J., Sitarek, P., Kowalczyk, T., Rieske, P., & Pawliczak, R. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17102 · Cited by 13 · see citing works
Human rhinovirus HRV16 impairs barrier functions and regeneration of human lung vascular endothelium
Gawrysiak, M., Gajewski, A., Szewczyk, R., Likońska, A., Michlewska, S., Chmiela, M., Kowalski, M. L., & Chałubiński, M. (2020) · Allergy · doi:10.1111/all.14671 · Cited by 13 · see citing works
Toll-Like Receptor Agonists Modulate Wound Regeneration in Airway Epithelial Cells
Lewandowska‐Polak, A., Brauncajs, M., Jarzębska, M., Pawelczyk, M., Kurowski, M. M., Chałubiński, M., Makowska, J. S., & Kowalski, M. L. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082456 · Cited by 12 · see citing works
Watkinson, R. L., Looi, K., Laing, I. A., Cianferoni, A., & Kicic, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.773600 · Cited by 10 · see citing works
Hoshiyama, T., Wada, T., Nihonyanagi, S., Kameda, R., Yamaoka‐Tojo, M., Fukuda, M., Ako, J., Yamaoka, K., & Takayama, Y. (2020) · Internal Medicine · doi:10.2169/internalmedicine.5601-20 · Cited by 7 · see citing works
Ground zero—the airway epithelium
Reid, A. T., Sutanto, E. N., Veerati, P. C., Looi, K., Li, N. F., Iosifidis, T., Loo, S.-L., Garratt, L. W., & Kicic, A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816417-4.00003-2 · Cited by 7 · see citing works
Iqbal, M., Feng, C., Zong, G., Wang, L., & Vasta, G. R. (2024) · Glycobiology · doi:10.1093/glycob/cwae093 · Cited by 6 · see citing works
Likońska, A., Gawrysiak, M., Gajewski, A., Klimczak, K., Michlewska, S., Szewczyk, R., Gulbas, I., & Chałubiński, M. (2022) · Apmis · doi:10.1111/apm.13269 · Cited by 6 · see citing works
Elevated Levels of Cytotoxicity, Cytokines, and Anti-SARS-CoV-2 Antibodies in Mild Cases of COVID-19
Fernández‐Rojas, M. A., Ávila, G., Romero‐Valdovinos, M., Plett-Torres, T., Salazar, A. M., Sordo, M., Chávez-Vargas, M., Ángeles, C. J. C., Cruz-Rivera, M. Y., Santiago-Olivares, C., et al. (2023) · Viral Immunology · doi:10.1089/vim.2023.0012 · Cited by 6 · see citing works
Rhinovirus and Respiratory Disease
Hershenson, M. B. (2014) · ASM Press eBooks · doi:10.1128/9781555816698.ch23 · Cited by 6 · see citing works
Exacerbations of chronic respiratory diseases
Edwards, M. R., Ritchie, A. I., & Johnston, S. L. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816417-4.00006-8 · Cited by 6 · see citing works
Ling, K., Garratt, L. W., Lassmann, T., Stick, S. M., Kicic, A., WAERP, AusREC, & Australian Respiratory Early Surveillance Team for Cystic Fibrosis (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01270 · Cited by 4 · see citing works
Antibiotics counteract the worsening of airway remodelling induced by infections in asthma
Lucini, V., Ciracì, R., Dugnani, S., Pannacci, M., Pisati, F., Caronno, A., Tirone, G., & Scaglione, F. (2014) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2014.02.005 · Cited by 3 · see citing works
Effect of particulate matter (PM10) on human neutrophils exposed to rhinovirus
Loaiza-Ceballos, M. C., Gómez-Gallego, D. M., & Hernández, J. C. (2025) · Air Quality Atmosphere & Health · doi:10.1007/s11869-025-01719-2 · Cited by 2 · see citing works
Effects of cryopreservation on antiviral responses of primary airway epithelial cells
Τaka, S., Nikopoulou, C., Polyzos, A., Megremis, S., Skevaki, C. L., Roumpedaki, E., Trochoutsou, A. I., Thanos, D., & Papadopoulos, N. G. (2019) · Allergy · doi:10.1111/all.14163 · Cited by 2 · see citing works
Self-citationRitchie, A. I., Mallia, P., & Johnston, S. L. (2017) · European Respiratory Society eBooks · doi:10.1183/2312508x.10016116 · Cited by 2 · see citing works
Erkältungsviren: Keine Hoffnung auf Immunität
Höffeler, F. (2008) · Biologie in unserer Zeit · doi:10.1002/biuz.200810368 · Cited by 1 · see citing works
Viruses and asthma exacerbations
Bossios, A., & Papadopoulos, N. G. (2006) · Breathe · doi:10.1183/18106838.0301.50 · Cited by 1 · see citing works
Self-citationInfections in the nose and exacerbations of chronic respiratory disorders
Xepapadaki, P. V., Megremis, S., Kitsioulis, N. A., & Papadopoulos, N. G. (2017) · European Respiratory Society eBooks · doi:10.1183/2312508x.10009916 · Cited by 1 · see citing works
Self-citationMacintyre, J. (2013) · Spiral (Imperial College London) · doi:10.25560/24921
Rhinovirus induced airway inflammation in naive and allergic mouse models
Nagarkar, D. R. (2010)
Common Colds and Respiratory Viruses: Impact on Allergy and Asthma
Velissariou, I. M., Xepapadaki, P. V., & Papadopoulos, N. G. (2009) · Springer eBooks · doi:10.1007/978-4-431-88317-3_9
Self-citationPotential Role of Early-life Rhinovirus Infection in the Development of Asthma.
Hong, J. Y. (2015) · Deep Blue (University of Michigan)
The role of the human cathelicidin LL-37 in rhinovirus infection
Sousa, F. H. (2026) · Edinburgh Napier Research Repository (Edinburgh Napier University) · doi:10.17869/enu.2026.2070903
INFECŢIA – FACTOR DE RISC PENTRU ASTMUL BRONŞIC LA COPIL
Murgu, A. M., & Goția, S. (2012) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.37897/rjp.2012.4.1
[Loss of libido during methimazole therapy].
Rd, H., & Herter, U. (1976) · PubMed
Asociación entre virus respiratorios y la exacerbación de asma en niños. Trujillo-Perú
Goicochea, C. R., Castillo, S. B., & Castillo, M. C. (2009) · Revista Peruana de Pediatría · doi:10.61651/rped.2009v62n1p01-07
Yarlagadda, T. (2023) · Queensland University of Technology · doi:10.5204/thesis.eprints.244715
Hincapie, V., Cardona, J. C., Gallego-Gómez, J. C., Julio, R. G. V., Yepes-Blandón, J. A., Ordoñez, B. E., Perez, G. A., & Cuartas-López, A. M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.11.617825
- Authors
- Bossios, A., Psarras, S., Gourgiotis, D., Skevaki, C. L., Constantopoulos, A. G., Saxoni-Papageorgiou, P., & Papadopoulos, N. G.
- Affiliations
- National and Kapodistrian University of Athens (GR)
- Corresponding author
- Bossios, Apostolos
- ORCID
- Venue
- Respiratory Research
- Published
- 2005-10-10
- Volume
- 6
- Issue
- 1
- Pages
- 114-114
- ISSN
- 1465-9921 (ISSN-L)
- 1465-993X
- PMC
- PMC1283981
- OpenAlex
- W2114203473
- Cited by
- 79
- References
- 43
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 7 · 2020: 6 · 2019: 6 · 2018: 5 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 3
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Respiratory Research (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Keywords
- human rhinovirus, bronchial epithelial cells, wound healing, epithelial repair, cell proliferation, acute asthma exacerbation, airway remodeling, BEAS-2B cells, proliferating cell nuclear antigen
- MeSH terms
- Bronchi, Cell Line, Epithelial Cells, HeLa Cells, Humans, Picornaviridae Infections, Time Factors, Wound Healing, Vascular Cell Adhesion Molecule-1, Respiratory Mucosa
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