Differential gene expression and Hog1 interaction with osmoresponsive genes in the extremely halotolerant black yeast Hortaea werneckii
Open accessAbstract
BACKGROUND: Fluctuations in external salinity force eukaryotic cells to respond by changes in the gene expression of proteins acting in protective biochemical processes, thus counteracting the changing osmotic pressure. The high-osmolarity glycerol (HOG) signaling pathway is essential for the efficient up-regulation of the osmoresponsive genes. In this study, the differential gene expression of the extremely halotolerant black yeast Hortaea werneckii was explored. Furthermore, the interaction of mitogen-activated protein kinase HwHog1 and RNA polymerase II with the chromatin in cells adapted to an extremely hypersaline environment was analyzed. RESULTS: A cDNA subtraction library was constructed for H. werneckii, adapted to moderate salinity or an extremely hypersaline environment of 4.5 M NaCl. An uncommon osmoresponsive set of 95 differentially expressed genes was identified. The majority of these had not previously been connected with the adaptation of salt-sensitive S. cerevisiae to hypersaline conditions. The transcriptional response in hypersaline-adapted and hypersaline-stressed cells showed that only a subset of the identified genes responded to acute salt-stress, whereas all were differentially expressed in adapted cells. Interaction with HwHog1 was shown for 36 of the 95 differentially expressed genes. The majority of the identified osmoresponsive and HwHog1-dependent genes in H. werneckii have not been previously reported as Hog1-dependent genes in the salt-sensitive S. cerevisiae. The study further demonstrated the co-occupancy of HwHog1 and RNA polymerase II on the chromatin of 17 up-regulated and 2 down-regulated genes in 4.5 M NaCl-adapted H. werneckii cells. CONCLUSION: Extremely halotolerant H. werneckii represents a suitable and highly relevant organism to study cellular responses to environmental salinity. In comparison with the salt-sensitive S. cerevisiae, this yeast shows a different set of genes being expressed at high salt concentrations and interacting with HwHog1 MAP kinase, suggesting atypical processes deserving of further study.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Duplications and large scale genomic variations, although they can lead to significant issues such as genomic instability, play a major role in yeast evolution.
“As such, ALE studies highlight that duplications and large scale genomic variations, although they can lead to significant issues such as genomic instability [152], play a major role in e.g. yeast evolution; this is also indicated by data on wine yeasts, galactose utilization, comparative genomics and drug resistance [115,153-156].”
From Adaptive laboratory evolution—Principles and applications for biotechnology (2013) · cites this paper as [155]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Osmotic Stress Signaling and Osmoadaptation in Yeasts
Hohmann, S. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.2.300-372.2002 · Cited by 1,773 · see citing works
Remodeling of Yeast Genome Expression in Response to Environmental Changes
Causton, H. C., Ren, B., Koh, S. S., Harbison, C. T., Kanin, E. I., Jennings, E. G., Lee, T. I., True, H. L., Lander, E. S., & Young, R. A. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.2.323 · Cited by 1,364 · see citing works
MIPS: a database for genomes and protein sequences
Mewes, H. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.1.37 · Cited by 1,276 · see citing works
Ruepp, A. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh894 · Cited by 1,134 · see citing works
Martínez‐Pastor, M. T., Marchler, G. H., Schüller, C., Marchler‐Bauer, A., Ruis, H., & Estruch, F. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00576.x · Cited by 1,077 · see citing works
MAP Kinase Pathways in the YeastSaccharomyces cerevisiae
Gustin, M., Albertyn, J., Alexander, M., & Davenport, K. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.4.1264-1300.1998 · Cited by 1,010 · see citing works
MIPS: a database for genomes and protein sequences
Mewes, H. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.1.31 · Cited by 784 · see citing works
Issel‐Tarver, L., Christie, K., Dolinski, K. J., Andrada, R., Balakrishnan, R., Ball, C. A., Binkley, G., Dong, S., Dwight, S. S., Fisk, D. G., et al. (2002) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(02)50972-1 · Cited by 672 · see citing works
The Transcriptional Response of Saccharomyces cerevisiae to Osmotic Shock
Rep, M., Krantz, M., Thevelein, J. M., & Hohmann, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.8290 · Cited by 554 · see citing works
Hypersaline waters in salterns – natural ecological niches for halophilic black yeasts
Gunde‐Cimerman, N., Zalar, P., de Hoog, S., & PlemenitaÅ¡, A. (2000) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2000.tb00716.x · Cited by 429 · see citing works
Self-citationThe Transcriptional Response of Yeast to Saline Stress
Posas, F., Chambers, J. R., Heyman, J. A., Hoeffler, J. P., de Nadal, E., & Ariño, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910016199 · Cited by 423 · see citing works
Proft, M., & Struhl, K. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00557-9 · Cited by 350 · see citing works
The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes
de Nadal, E., Zapater, M., Alepuz, P. M., Sumoy, L., Martín, G. M., & Posas, F. (2004) · Nature · doi:10.1038/nature02258 · Cited by 316 · see citing works
Rep, M., Reiser, V., Gärtner, U., Thevelein, J. M., Hohmann, S., Ammerer, G., & Ruis, H. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.8.5474 · Cited by 283 · see citing works
O’Rourke, S. M., & Herskowitz, I. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-07-0521 · Cited by 262 · see citing works
Stress-Induced MAP Kinase Hog1 Is Part of Transcription Activation Complexes
Alepuz, P. M., Jovanović, A., Reiser, V., & Ammerer, G. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00221-0 · Cited by 249 · see citing works
Dealing with osmostress through MAP kinase activation
de Nadal, E., Alepuz, P. M., & Posas, F. (2002) · EMBO Reports · doi:10.1093/embo-reports/kvf158 · Cited by 233 · see citing works
Leptosphaeria rhodopsin: Bacteriorhodopsin-like proton pump from a eukaryote
Waschuk, S. A., Bezerra, A. G., Shi, L., & Brown, L. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409659102 · Cited by 228 · see citing works
Transcript Expression in Saccharomyces cerevisiae at High Salinity
Yale, J., & Bohnert, H. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008209200 · Cited by 226 · see citing works
Proft, M., Pascual‐Ahuir, A., de Nadal, E., Ariño, J., Serrano, R., & Posas, F. (2001) · The EMBO Journal · doi:10.1093/emboj/20.5.1123 · Cited by 218 · see citing works
Reiser, V., Ruis, H., & Ammerer, G. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.4.1147 · Cited by 215 · see citing works
Osmostress‐induced transcription by Hot1 depends on a Hog1‐mediated recruitment of the RNA Pol II
Alepuz, P. M., de Nadal, E., Zapater, M., Ammerer, G., & Posas, F. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg243 · Cited by 191 · see citing works
Turk, M., Méjanelle, L., Šentjurc, M., Grimalt, J. O., Gunde‐Cimerman, N., & Plemenitaš, A. (2003) · Extremophiles · doi:10.1007/s00792-003-0360-5 · Cited by 181 · see citing works
Self-citationHecht, A., & GRUNSTEIN, M. M. (1999) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(99)04024-0 · Cited by 171 · see citing works
de Nadal, E., Casadomé, L., & Posas, F. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.23.1.229-237.2003 · Cited by 171 · see citing works
Proft, M., Martín, G. M., de Nadal, E., Vendrell, A., Noriega, N., Struhl, K., & Posas, F. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.05.031 · Cited by 155 · see citing works
Rebrikov, D. V. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.20.e90 · Cited by 134 · see citing works
Rep, M., Albertyn, J., Thevelein, J. M., Prior, B. A., & Hohmann, S. (1999) · Microbiology · doi:10.1099/13500872-145-3-715 · Cited by 131 · see citing works
Kogej, T., Ramos, J., Plemenitaš, A., & Gunde‐Cimerman, N. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.11.6600-6605.2005 · Cited by 115 · see citing works
Self-citationCellular responses to environmental salinity in the halophilic black yeast Hortaea werneckii
Petrovič, U., Gunde‐Cimerman, N., & Plemenitaš, A. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03021.x · Cited by 109 · see citing works
Self-citationGeisberg, J. V. (2004) · Nucleic Acids Research · doi:10.1093/nar/gnh148 · Cited by 107 · see citing works
Turk, M., & PlemenitaÅ¡, A. (2002) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2002.tb11435.x · Cited by 52 · see citing works
Self-citationGorjan, A., & PlemenitaÅ¡, A. (2006) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2006.00473.x · Cited by 34 · see citing works
Self-citationSalt stress affects sterol biosynthesis in the halophilic black yeastHortaea werneckii
Petrovič, U., Gunde‐Cimerman, N., & PlemenitaÅ¡, A. (1999) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1999.tb08813.x · Cited by 32 · see citing works
Self-citationSalt stress affects sterol biosynthesis in the halophilic black yeast Hortaea werneckii
Petrovič, U. (1999) · FEMS Microbiology Letters · doi:10.1016/s0378-1097(99)00501-7 · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Adaptive laboratory evolution—Principles and applications for biotechnology
Dragosits, M., & Mattanovich, D. (2013) · Microbial Cell Factories · doi:10.1186/1475-2859-12-64 · Cited by 827 · see citing works
Strategies of adaptation of microorganisms of the three domains of life to high salt concentrations
Gunde‐Cimerman, N., Plemenitaš, A., & Oren, A. (2018) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuy009 · Cited by 584 · see citing works
Self-citationHalotolerant and halophilic fungi
Gunde‐Cimerman, N., Ramos, J., & Plemenitaš, A. (2009) · Mycological Research · doi:10.1016/j.mycres.2009.09.002 · Cited by 300 · see citing works
Self-citationExtremotolerance in fungi: evolution on the edge
Gostinčar, C., Grube, M., de Hoog, S., Zalar, P., & Gunde‐Cimerman, N. (2009) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2009.00794.x · Cited by 239 · see citing works
Properties of the halophyte microbiome and their implications for plant salt tolerance
Ruppel, S., Franken, P., & Witzel, K. (2013) · Functional Plant Biology · doi:10.1071/fp12355 · Cited by 190 · see citing works
Limits of life in hostile environments: no barriers to biosphere function?
Williams, J. P., & Hallsworth, J. E. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.02079.x · Cited by 171 · see citing works
Adaptive response and tolerance to sugar and salt stress in the food yeast Zygosaccharomyces rouxii
Dakal, T. C., Solieri, L., & Giudici, P. (2014) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2014.05.015 · Cited by 144 · see citing works
Gal-Hemed, I., Atanasova, L., Komoñ‐Zelazowska, M., Druzhinina, I. S., Viterbo, A., & Yarden, O. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.00541-11 · Cited by 137 · see citing works
Adaptation to high salt concentrations in halotolerant/halophilic fungi: a molecular perspective
PlemenitaÅ¡, A., Lenassi, M., Konte, T., ar, A. K. ⁄., Zajc, J., Gostinčar, C., & Gunde‐Cimerman, N. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00199 · Cited by 129 · see citing works
Self-citationYeasts Inhabiting Extreme Environments and Their Biotechnological Applications
Segal‐Kischinevzky, C., Romero‐Aguilar, L., Alcaraz, L. D., López-Ortiz, G., Martínez-Castillo, B., Torres‐Ramírez, N., Sandoval, G., & González, J. (2022) · Microorganisms · doi:10.3390/microorganisms10040794 · Cited by 126 · see citing works
Zajc, J., Liu, Y., Dai, W., Yang, Z., Hu, J., Gostinčar, C., & Gunde‐Cimerman, N. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-617 · Cited by 121 · see citing works
Plemenitaš, A., Vaupotič, T., Lenassi, M., Kogej, T., & Gunde‐Cimerman, N. (2008) · Studies in Mycology · doi:10.3114/sim.2008.61.06 · Cited by 114 · see citing works
Self-citationFungal Adaptation to Extremely High Salt Concentrations
Gostinčar, C., Lenassi, M., Gunde‐Cimerman, N., & Plemenitaš, A. (2011) · Advances in applied microbiology · doi:10.1016/b978-0-12-387044-5.00003-0 · Cited by 113 · see citing works
Self-citationLenassi, M., Gostinčar, C., Jackman, S. D., Turk, M., Sadowski, I., Nislow, C., Jones, S. J. M., Birol, İ., Cimerman, N. G., & Plemenitaš, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071328 · Cited by 105 · see citing works
Self-citationKejžar, A., Gobec, S., Plemenitaš, A., & Lenassi, M. (2013) · Fungal Biology · doi:10.1016/j.funbio.2013.03.006 · Cited by 86 · see citing works
Self-citationThe response to unfolded protein is involved in osmotolerance of Pichia pastoris
Dragosits, M., Stadlmann, J., Graf, A. B., Gasser, B., Maurer, M., Sauer, M., Kreil, D. P., Altmann, F., & Mattanovich, D. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-207 · Cited by 82 · see citing works
Extremophilic yeasts: plasma-membrane fluidity as determinant of stress tolerance
Turk, M., Plemenitaš, A., & Gunde‐Cimerman, N. (2011) · Fungal Biology · doi:10.1016/j.funbio.2011.04.006 · Cited by 64 · see citing works
Self-citationHarding, T., Roger, A. J., & Simpson, A. G. B. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00944 · Cited by 61 · see citing works
Alkayal, F., Albion, R. L., Tillett, R. L., Hathwaik, L. T., Lemos, M. S., & Cushman, J. C. (2010) · Plant Science · doi:10.1016/j.plantsci.2010.07.001 · Cited by 55 · see citing works
Lenassi, M., Zajc, J., Gostinčar, C., Gorjan, A., Gunde‐Cimerman, N., & Plemenitaš, A. (2011) · Fungal Biology · doi:10.1016/j.funbio.2011.04.001 · Cited by 47 · see citing works
Self-citationVaupotič, T., Veranič, P., Jenoe, P., & Plemenitaš, A. (2008) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2008.01.006 · Cited by 45 · see citing works
Self-citationSinha, S., Flibotte, S., Neira, M., Formby, S., Plemenitaš, A., Gunde‐Cimerman, N., Lenassi, M., Gostinčar, C., Stajich, J., & Nislow, C. (2017) · G3 Genes Genomes Genetics · doi:10.1534/g3.117.040691 · Cited by 45 · see citing works
Self-citationOverview of Oxidative Stress Response Genes in Selected Halophilic Fungi
Gostinčar, C., & Gunde‐Cimerman, N. (2018) · Genes · doi:10.3390/genes9030143 · Cited by 44 · see citing works
Zajc, J., Zalar, P., Plemenitaš, A., & Gunde‐Cimerman, N. (2011) · Progress in molecular and subcellular biology · doi:10.1007/978-3-642-23342-5_7 · Cited by 43 · see citing works
Self-citationGostinčar, C., Turk, M., PlemenitaÅ¡, A., & Gunde‐Cimerman, N. (2009) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2009.00481.x · Cited by 41 · see citing works
Self-citationUnderstanding Fungi in Glacial and Hypersaline Environments
Gostinčar, C., & Gunde‐Cimerman, N. (2023) · Annual Review of Microbiology · doi:10.1146/annurev-micro-032521-020922 · Cited by 35 · see citing works
Recent Trends in Microbial Approaches for Soil Desalination
Mokrani, S., Nabti, E.-H., & Cruz, C. (2022) · Applied Sciences · doi:10.3390/app12073586 · Cited by 30 · see citing works
Konte, T., & Plemenitaš, A. (2013) · Extremophiles · doi:10.1007/s00792-013-0546-4 · Cited by 28 · see citing works
Self-citationHalophilic Fungi—Features and Potential Applications
Yovchevska, L., Gocheva, Y. G., Stoyancheva, G. D., Miteva‐Staleva, J., Dishliyska, V., Abrashev, R., Stamenova, T., Angelova, M., & Krumova, E. T. (2025) · Microorganisms · doi:10.3390/microorganisms13010175 · Cited by 26 · see citing works
Solieri, L., Vezzani, V., Cassanelli, S., Dakal, T. C., Pazzini, J., & Giudici, P. (2016) · FEMS Yeast Research · doi:10.1093/femsyr/fow063 · Cited by 26 · see citing works
Yeasts in Hypersaline Habitats
Zajc, J., Zalar, P., & Gunde‐Cimerman, N. (2017) · Springer eBooks · doi:10.1007/978-3-319-62683-3_10 · Cited by 26 · see citing works
Transport Systems in Halophilic Fungi
Plemenitaš, A., Konte, T., Gostinčar, C., & Gunde‐Cimerman, N. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-25304-6_13 · Cited by 24 · see citing works
Self-citationGostinčar, C., Stajich, J., Kejžar, A., Sinha, S., Nislow, C., Lenassi, M., & Gunde‐Cimerman, N. (2021) · Journal of Fungi · doi:10.3390/jof7090723 · Cited by 22 · see citing works
Kejžar, A., Grøtli, M., Tamás, M. J., Plemenitaš, A., & Lenassi, M. (2014) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2014.11.004 · Cited by 20 · see citing works
Self-citationEukaryotic Life in Extreme Environments: Acidophilic Fungi
Aguilera, Á., & González‐Toril, E. (2019) · Springer eBooks · doi:10.1007/978-3-030-19030-9_2 · Cited by 20 · see citing works
Black yeasts in hypersaline conditions
Gostinčar, C., & Gunde‐Cimerman, N. (2024) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-024-13052-2 · Cited by 17 · see citing works
Plemenitaš, A. (2021) · Journal of Fungi · doi:10.3390/jof7110988 · Cited by 17 · see citing works
Self-citationPhysiology, Biochemistry, and Biotechnology
Raghukumar, S. (2017) · Springer eBooks · doi:10.1007/978-3-319-54304-8_13 · Cited by 16 · see citing works
Fettich, M., Lenassi, M., Veranič, P., Gunde‐Cimerman, N., & Plemenitaš, A. (2011) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2011.01.011 · Cited by 14 · see citing works
Self-citationThe unique characteristics of HOG pathway MAPKs in the extremely halotolerant Hortaea werneckii
Kejžar, A., Cibic, M., Grøtli, M., Plemenitaš, A., & Lenassi, M. (2015) · FEMS Microbiology Letters · doi:10.1093/femsle/fnv046 · Cited by 12 · see citing works
Self-citationEcological Perspectives of Halophilic Fungi and their Role in Bioremediation
Jain, S., Choudhary, D. K., & Varma, A. K. (2021) · Wiley eBooks · doi:10.1002/9781119547976.ch8 · Cited by 12 · see citing works
Anthonies, S., & Vargas-Muñiz, J. M. (2022) · Frontiers in Fungal Biology · doi:10.3389/ffunb.2022.941691 · Cited by 10 · see citing works
Salty sisters: The women of halophiles
Baxter, B. K., Gunde‐Cimerman, N., & Oren, A. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00192 · Cited by 8 · see citing works
Raghukumar, S. (2017) · Springer eBooks · doi:10.1007/978-3-319-54304-8_12 · Cited by 6 · see citing works
Xerophilic fungal genus Wallemia: Bioactive inhabitants of marine solar salterns and salty food
Zajc, J., Zalar, P., Sepčić, K., & Gunde‐Cimerman, N. (2011) · Zbornik Matice srpske za prirodne nauke · doi:10.2298/zmspn1120007z · Cited by 6 · see citing works
Plemenitaš, A., & Gunde‐Cimerman, N. (2011) · Springer eBooks · doi:10.1007/978-3-642-20198-1_7 · Cited by 4 · see citing works
Self-citationCellular responses of Aspergillus sydowii to growth at extreme chaotropic concentrations of MgCl2
González‐Abradelo, D., de León, L. R., Gesto-Borroto, R., Moreno-Perlín, T., Sánchez, N. D. C., Pérez‐Llano, Y., Cabral-Miramontes, J. P., Aréchiga-Carbajal, E., Sánchez‐Carbente, M. D. R., Gostinčar, C., et al. (2025) · Microbiological Research · doi:10.1016/j.micres.2025.128390 · Cited by 3 · see citing works
Fungal and Fungal-like Diseases of Halophytes in the Mediterranean Basin: A State-of-the-Art Review
Compagni, E. D., Pardossi, A., & Pecchia, S. (2024) · Horticulturae · doi:10.3390/horticulturae10040313 · Cited by 2 · see citing works
Gonçalves, V. N., Soares, F. O., Corrêa, G. R., Senra, E. O., Lopes, F. Á. C., Carvalho‐Silva, M., Convey, P., Câmara, P. E. A. S., Duarte, A. W. F., & Rosa, L. H. (2025) · Brazilian Journal of Microbiology · doi:10.1007/s42770-025-01698-7 · Cited by 2 · see citing works
Zhang, J., Cai, L., Chen, Y., Ma, T., Wang, H., & Zhang, C. (2025) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2025.106620 · Cited by 1 · see citing works
Rabelo, N. G., Gonçalves, V. N., Neto, A. A., Vieira, R., Caram, T. N., Malheiros, M. M., Lopes, F. Á. C., Carvalho‐Silva, M., de Azevedo, A. Q., Gonçalves, T. R., et al. (2025) · DNA · doi:10.3390/dna5030045 · Cited by 1 · see citing works
Stress-Induced Cross-Protection and Combined Stress Responses in Extremotolerant Black Yeasts
Fortuna, K., Kajin, M., & Gostinčar, C. (2026) · Journal of Fungi · doi:10.3390/jof12010043 · Cited by 1 · see citing works
Hernández-Rodríguez, Y., Bullard, A. M., Busch, R. J., Marshall, A., & Vargas-Muñiz, J. M. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.02430-24 · Cited by 1 · see citing works
Molecular characterization of the black yeast Hortaea werneckii in saline environments
Formby, S. (2017) · cIRcle (University of British Columbia) · doi:10.14288/1.0348742 · Cited by 1 · see citing works
Distribution and diversity in microbial enzymes
Belorkar, S. A., & Jogaiah, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-91268-6.00013-2
Chaotolerant Fungi: An Unexplored Group of Extremophile
Sahay, S. (2022) · Springer eBooks · doi:10.1007/978-981-16-4907-3_12
- Authors
- Vaupotič, T., & Plemenitaš, A.
- Affiliations
- University of Ljubljana (SI)
- Corresponding author
- Plemenitaš, Ana
- Venue
- BMC Genomics
- Published
- 2007
- Volume
- 8
- Issue
- 1
- Pages
- 280
- ISSN
- 1471-2164 (ISSN-L)
- PMC
- PMC2034391
- OpenAlex
- W2123047375
- Cited by
- 56
- References
- 35
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 4 · 2019: 1 · 2018: 2 · 2017: 6 · 2016: 1 · 2015: 2 · 2014: 4 · 2013: 6
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- BMC Genomics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Javna Agencija za Raziskovalno Dejavnost RS (P1-0170)
- University of California, San Francisco
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Stress Responses and Tolerance
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- Hortaea werneckii, black yeast, halotolerance, Hog1 MAP kinase, differential gene expression, RNA polymerase II, salt stress response, Saccharomyces cerevisiae comparison
- MeSH terms
- Osmotic Pressure, Sodium Chloride, Yeasts, Signal Transduction, Up-Regulation, Gene Expression Regulation, Fungal, Mitogen-Activated Protein Kinases, Saccharomyces cerevisiae Proteins, Salinity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
