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Cited by 516Pregnancy and preeclampsia studiesReproductive System and PregnancyPreterm Birth and Chorioamnionitis

The DOI matches its Crossref record; 45 of the 46 references it cites were found in a registry or an index.

Circulating cytokines, chemokines and adhesion molecules in normal pregnancy and preeclampsia determined by multiplex suspension array

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Szarka, András, Rigó, János, Lázár, Levente, Bekő, Gabriella, Molvarec, Attila·2010·BMC Immunology
DOI 10.1186/1471-2172-11-59PMC PMC3014878
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Abstract

BACKGROUND: Preeclampsia is a severe complication of pregnancy characterized by an excessive maternal systemic inflammatory response with activation of both the innate and adaptive arms of the immune system. Cytokines, chemokines and adhesion molecules are central to innate and adaptive immune processes. The purpose of this study was to determine circulating levels of cytokines, chemokines and adhesion molecules in normal pregnancy and preeclampsia in a comprehensive manner, and to investigate their relationship to the clinical features and laboratory parameters of the study participants, including markers of overall inflammation (C-reactive protein), endothelial activation (von Willebrand factor antigen) and endothelial injury (fibronectin), oxidative stress (malondialdehyde) and trophoblast debris (cell-free fetal DNA). RESULTS: Serum levels of interleukin (IL)-1beta, IL-1 receptor antagonist (IL-1ra), IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p40, IL-12p70, IL-18, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, transforming growth factor (TGF)-beta1, interferon-gamma-inducible protein (IP)-10, monocyte chemotactic protein (MCP)-1, intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 were measured in 60 preeclamptic patients, 60 healthy pregnant women and 59 healthy non-pregnant women by multiplex suspension array and ELISA. In normal pregnancy, the relative abundance of circulating IL-18 over IL-12p70 and the relative deficiency of the bioactive IL-12p70 in relation to IL-12p40 might favour Th2-type immunity. Although decreased IL-1ra, TNF-alpha and MCP-1 concentrations of healthy pregnant relative to non-pregnant women reflect anti-inflammatory changes in circulating cytokine profile, their decreased serum IL-10 and increased IP-10 levels might drive pro-inflammatory responses. In addition to a shift towards Th1-type immunity (expressed by the increased IL-2/IL-4 and IFN-gamma/IL-4 ratios), circulating levels of the pro-inflammatory cytokines IL-6 and TNF-alpha, the chemokines IL-8, IP-10 and MCP-1, as well as the adhesion molecules ICAM-1 and VCAM-1, were raised in preeclampsia compared with healthy pregnancy, resulting in an overall pro-inflammatory systemic environment. Increased IP-10, MCP-1, ICAM-1 and VCAM-1 concentrations of preeclamptic patients showed significant correlations with blood pressure values, renal and liver function parameters, as well as with CRP, malondialdehyde, von Willebrand factor antigen and fibronectin levels. CONCLUSIONS: According to our findings, preeclampsia was associated with an overall pro-inflammatory systemic environment. Elevated amounts of pro-inflammatory cytokines, chemokines and adhesion molecules in the maternal circulation might play a central role in the excessive systemic inflammatory response, as well as in the generalized endothelial dysfunction characteristics of the maternal syndrome of preeclampsia.

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Figure 1 IL(interleukin)-2/IL-4 ratios of healthy non-pregnant and pregnant women and preeclamptic patients. Middle point: median; Box: interquartile range (25-75 percentile); Whisker: range (excluding outliers); a p < 0.001 versus healthy non-pregnant women; b p < 0.05 versus healthy pregnant women
Figure 1 IL(interleukin)-2/IL-4 ratios of healthy non-pregnant and pregnant women and preeclamptic patients. Middle point: median; Box: interquartile range (25-75 percentile); Whisker: range (excluding outliers); a p < 0.001 versus healthy non-pregnant women; b p < 0.05 versus healthy pregnant womenCC BY · PubMed Central
Figure 2 IFN(interferon)-γ/IL(interleukin)-4 ratios of healthy non-pregnant and pregnant women and preeclamptic patients. Middle point: median; Box: interquartile range (25-75 percentile); Whisker: range (excluding outliers); a p < 0.05 versus healthy pregnant women
Figure 2 IFN(interferon)-γ/IL(interleukin)-4 ratios of healthy non-pregnant and pregnant women and preeclamptic patients. Middle point: median; Box: interquartile range (25-75 percentile); Whisker: range (excluding outliers); a p < 0.05 versus healthy pregnant womenCC BY · PubMed Central
Figure 3 IL(interleukin)-18/IL-12p70 ratios of healthy non-pregnant and pregnant women and preeclamptic patients. Middle point: median; Box: interquartile range (25-75 percentile); Whisker: range (excluding outliers); a p < 0.001 versus healthy non-pregnant women
Figure 3 IL(interleukin)-18/IL-12p70 ratios of healthy non-pregnant and pregnant women and preeclamptic patients. Middle point: median; Box: interquartile range (25-75 percentile); Whisker: range (excluding outliers); a p < 0.001 versus healthy non-pregnant womenCC BY · PubMed Central
Figure 4 IL(interleukin)-12p70/IL-12p40 ratios of healthy non-pregnant and pregnant women and preeclamptic patients. Middle point: median; Box: interquartile range (25-75 percentile); Whisker: range (excluding outliers); a p < 0.001 versus healthy non-pregnant women
Figure 4 IL(interleukin)-12p70/IL-12p40 ratios of healthy non-pregnant and pregnant women and preeclamptic patients. Middle point: median; Box: interquartile range (25-75 percentile); Whisker: range (excluding outliers); a p < 0.001 versus healthy non-pregnant womenCC BY · PubMed Central

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  1. Joubert K: Standards of the body mass and body length of birth in Hungary on the basis of the 1990-1996 nation-wide liveborn data. Magy Noorv L. 2000, 63: 155-163.

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Metadata

Authors
Szarka, A., Rigó, J., Lázár, L., Bekő, G., & Molvarec, A.
Affiliations
Semmelweis University (HU)
Corresponding author
Molvarec, Attila
ORCID
Venue
BMC Immunology
Publisher
Springer Science and Business Media LLC
Published
2010-12
Volume
11
Issue
1
Pages
59-59
ISSN
1471-2172 (ISSN-L)
DOI
10.1186/1471-2172-11-59
PMC
PMC3014878
OpenAlex
W2079231160
Cited by
516
References
46
Citations by year
2026: 7 · 2025: 29 · 2024: 27 · 2023: 31 · 2022: 28 · 2021: 30 · 2020: 45 · 2019: 31 · 2018: 37 · 2017: 37 · 2016: 33 · 2015: 47 · 2014: 48 · 2013: 34 · 2012: 34
FWCI
37.65
Type
journal article
Language
en
Open access
Licence
Locations
  • BMC Immunology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • Semmelweis Egyetem
  • Magyar Tudományos Akadémia
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
  • Health Sciences › Medicine › Obstetrics and Gynecology › Preterm Birth and Chorioamnionitis
Keywords
preeclampsia, normal pregnancy, serum cytokines, chemokines, adhesion molecules, systemic inflammation, Th1/Th2 balance, IL-18, IL-12p70, CXCL10, MCP-1, ICAM-1, VCAM-1, TNF-α, interleukin-6, oxidative stress, endothelial activation, trophoblast
MeSH terms
Adult, C-Reactive Protein, Enzyme-Linked Immunosorbent Assay, Female, Fibronectins, Humans, Inflammation, Pre-Eclampsia, Pregnancy, von Willebrand Factor, Cell Adhesion Molecules, Cytokines, Oxidative Stress, Microarray Analysis, Th1-Th2 Balance

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