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No detectable effect of RNA-binding protein Hfq absence in Staphylococcus aureus
Open accessAbstract
Background: The RNA-binding protein Hfq is involved in stress and virulence of several pathogens, probably due to its role as mediator in small RNA (sRNA)-mRNA interactions. In this study, we investigate the function of Hfq in the Gram-positive pathogen Staphylococcus aureus, by constructing hfq null mutant derivatives. Results: We report that unexpectedly, in S. aureus, Hfq does not seem to play a crucial role in stress response, RNAIII or spa mRNA quantity and exoprotein expression, as tested in three virulent genetic backgrounds. Moreover, a global analysis of the RN6390 hfq mutant, which tests ~ 2000 phenotypes, supports our results concerning the non-implication of Hfq in stress response, and shows that Hfq is also not involved in resistance to several chemical agents and antibiotics and does not seem to be implicated in metabolic pathways. Conclusion: Our data suggest that although sRNA-mRNA interactions in S. aureus are decisive for gene expression regulation, they do not require the RNA-chaperone protein Hfq. These interactions possibly require an RNA-chaperone protein other than Hfq, which remains to be found.
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Cited by
Quorum Sensing in Staphylococci
Novick, R. P., & Geisinger, E. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.42.110807.091640 · Cited by 958
Boisset, S., Geissmann, T., Huntzinger, E., Fechter, P., Bendridi, N., Possedko, M., Chevalier, C., Helfer, A. C., Benito, Y., Jacquier, A., et al. (2007) · Genes & Development · doi:10.1101/gad.423507 · Cited by 490
Peptide Signaling in the Staphylococci
Thoendel, M., Kavanaugh, J. S., Flack, C. E., & Horswill, A. R. (2011) · Chemical Reviews · doi:10.1021/cr100370n · Cited by 438
sRNA-controlled iron sparing response in Staphylococci
Coronel-Tellez, R. H., Pospiech, M., Barrault, M., Liu, W., Bordeau, V., Vasnier, C., Felden, B., Sargueil, B., & Bouloc, P. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac648 · Cited by 43
Self-citationBarrault, M., Chabelskaya, S., Coronel-Tellez, R. H., Toffano-Nioche, C., Jacquet, E., & Bouloc, P. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae506 · Cited by 20
Metadata
- Authors
- Bohn, C., Rigoulay, C., & Bouloc, P.
- Venue
- BMC Microbiology
- Published
- 2007-02-09
- Volume
- 7
- Issue
- 1
- Pages
- 10-10
- ISSN
- 1471-2180 (ISSN-L)
- OpenAlex
- W1716385481
- Cited by
- 187
- References
- 0
- FWCI
- 7.54
- Type
- journal article
- Language
- en
- Open access
- gold
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- Bohn, C., Rigoulay, C., & Bouloc, P. (2007). No detectable effect of RNA-binding protein Hfq absence in Staphylococcus aureus. BMC Microbiology. https://doi.org/10.1186/1471-2180-7-10
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