The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Staphylococcus aureus RNAIII coordinately represses the synthesis of virulence factors and the transcription regulator Rot by an antisense mechanism
Open accessAbstract
RNAIII is the intracellular effector of the quorum-sensing system in Staphylococcus aureus. It is one of the largest regulatory RNAs (514 nucleotides long) that are known to control the expression of a large number of virulence genes. Here, we show that the 3′ domain of RNAIII coordinately represses at the post-transcriptional level, the expression of mRNAs that encode a class of virulence factors that act early in the infection process. We demonstrate that the 3′ domain acts primarily as an antisense RNA and rapidly anneals to these mRNAs, forming long RNA duplexes. The interaction between RNAIII and the mRNAs results in repression of translation initiation and triggers endoribonuclease III hydrolysis. These processes are followed by rapid depletion of the mRNA pool. In addition, we show that RNAIII and its 3′ domain mediate translational repression of rot mRNA through a limited number of base pairings involving two loop–loop interactions. Since Rot is a transcriptional regulatory protein, we proposed that RNAIII indirectly acts on many downstream genes, resulting in the activation of the synthesis of several exoproteins. These data emphasize the multitude of regulatory steps affected by RNAIII and its 3′ domain in establishing a network of S. aureus virulence factors.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The toxic shock syndrome exotoxin structural gene is not detectably transmitted by a prophage
Kreiswirth, B. N., Löfdahl, S., Betley, M. J., O'Reilly, M., Schlievert, P. M., Bergdoll, M. S., & Novick, R. P. (1983) · Nature · doi:10.1038/305709a0 · Cited by 1,326
Autoinduction and signal transduction in the regulation of staphylococcal virulence
Novick, R. P. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03526.x · Cited by 1,280
Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule.
Novick, R. P., Ross, H. F., Projan, S. J., Kornblum, J., Kreiswirth, B., & Moghazeh, S. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06074.x · Cited by 1,072
Arnaud, M., Chastanet, A., & Débarbouillé, M. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.11.6887-6891.2004 · Cited by 944
Dunman, P. M., Murphy, E., Haney, S., Palacios, D., Tucker-Kellogg, G., Wu, S., Brown, E. L., Zagursky, R. J., Shlaes, D., & Projan, S. J. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.24.7341-7353.2001 · Cited by 648
Peng, H. L., Novick, R. P., Kreiswirth, B., Kornblum, J., & Schlievert, P. (1988) · Journal of Bacteriology · doi:10.1128/jb.170.9.4365-4372.1988 · Cited by 566
Micros for microbes: non-coding regulatory RNAs in bacteria
Gottesman, S. (2005) · Trends in Genetics · doi:10.1016/j.tig.2005.05.008 · Cited by 501
MicroReview: The bacterial Sm‐like protein Hfq: a key player in RNA transactions
Valentin‐Hansen, P., Eriksen, M., & Udesen, C. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2003.03935.x · Cited by 494
Morfeldt, E., Taylor, D., von Gabain, A., & Arvidson, S. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00136.x · Cited by 476
Horinouchi, S., & Weisblum, B. (1982) · Journal of Bacteriology · doi:10.1128/jb.150.2.804-814.1982 · Cited by 471
Cited by
Peptide Signaling in the Staphylococci
Thoendel, M., Kavanaugh, J. S., Flack, C. E., & Horswill, A. R. (2011) · Chemical Reviews · doi:10.1021/cr100370n · Cited by 438
Genetic control of bacterial biofilms
Wolska, K. I., Grudniak, A. M., Rudnicka, Z., & Markowska, K. (2016) · Journal of Applied Genetics · doi:10.1007/s13353-015-0309-2 · Cited by 154
Alonzo III, F., Benson, M. A., Chen, J., Novick, R. P., Shopsin, B., & Torres, V. J. (2012) · Molecular Microbiology · doi:10.1111/j.1365-2958.2011.07942.x · Cited by 155
Deep sequencing-based identification of small non-coding RNAs in Streptomyces coelicolor
Vockenhuber, M.-P., Sharma, C. M., Statt, M. G., Schmidt, D., Xu, Z., Dietrich, S., Liesegang, H., Mathews, D. H., & Suess, B. (2011) · RNA Biology · doi:10.4161/rna.8.3.14421 · Cited by 88
Yang, X., Peng, Z., He, M., Li, Z., Fu, G., Li, S., & Zhang, J. (2024) · Science of The Total Environment · doi:10.1016/j.scitotenv.2023.167587 · Cited by 51
Metadata
- Authors
- Boisset, S., Geissmann, T., Huntzinger, E., Fechter, P., Bendridi, N., Possedko, M., Chevalier, C., Helfer, A. C., Benito, Y., Jacquier, A., Gaspin, C., Vandenesch, F., & Romby, P.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2007-06-01
- Volume
- 21
- Issue
- 11
- Pages
- 1353-1366
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2101153968
- Cited by
- 490
- References
- 44
- Type
- posted content
- Language
- en
- Open access
- diamond
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Staphylococcus aureus RNAIII coordinately represses the synthesis of virulence factors and the transcription regulator Rot by an antisense mechanism. https://app.cochat.ai/papers/10.1101/gad.423507
- The paper
- Boisset, S., Geissmann, T., Huntzinger, E., Fechter, P., Bendridi, N., Possedko, M., Chevalier, C., Helfer, A. C., Benito, Y., Jacquier, A., Gaspin, C., Vandenesch, F., & Romby, P. (2007). Staphylococcus aureus RNAIII coordinately represses the synthesis of virulence factors and the transcription regulator Rot by an antisense mechanism. Genes & Development. https://doi.org/10.1101/gad.423507
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
