The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Probiotic Lactobacillus reuteri biofilms produce antimicrobial and anti-inflammatory factors
Open accessAbstract
BACKGROUND: Commensal-derived probiotic bacteria inhibit enteric pathogens and regulate host immune responses in the gastrointestinal tract, but studies examining specific functions of beneficial microbes in the context of biofilms have been limited in scope. RESULTS: Lactobacillus reuteri formed biofilms that retained functions potentially advantageous to the host including modulation of cytokine output and the production of the antimicrobial agent, reuterin. Immunomodulatory activities of biofilms were demonstrated by the abilities of specific L. reuteri strains to suppress human TNF production by LPS-activated monocytoid cells. Quantification of the antimicrobial glycerol derivative, reuterin, was assessed in order to document the antipathogenic potential of probiotic biofilms. L. reuteri biofilms differed in the quantities of reuterin secreted in this physiological state. CONCLUSION: L. reuteri biofilms secreted factors that confer specific health benefits such as immunomodulation and pathogen inhibition. Future probiotic selection strategies should consider a strain's ability to perform beneficial functions as a biofilm.
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Cites
Swidsinski, A., Weber, J., Loening-Baucke, V., Hale, L. P., & Lochs, H. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.7.3380-3389.2005 · Cited by 894 · cited 3×
“Using non-aqueous fixatives and special techniques, several groups have documented the presence of intestinal biofilms in the mammalian intestine [14-17].”
BackgroundZoetendal, E. G., von Wright, A., Vilpponen-Salmela, T., Ben-Amor, K., Akkermans, A. D. L., & de Vos, W. M. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.7.3401-3407.2002 · Cited by 868
Microbial biofilms in the human gastrointestinal tract
Macfarlane, S., & Dillon, J. F. (2007) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2007.03287.x · Cited by 379 · cited 1×
“Using non-aqueous fixatives and special techniques, several groups have documented the presence of intestinal biofilms in the mammalian intestine [14-17].”
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Cited by
Bailey, M. T., Dowd, S. E., Galley, J. D., Hufnagle, A. R., Allen, R. G., & Lyte, M. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.10.023 · Cited by 1,123
Hemarajata, P., & Versalovic, J. (2013) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x12459294 · Cited by 1,083
Self-citationSharma, S., Mohler, J., Mahajan, S. D., Schwartz, S. A., Bruggemann, L., & Aalinkeel, R. (2023) · Microorganisms · doi:10.3390/microorganisms11061614 · Cited by 993
Stress Physiology of Lactic Acid Bacteria.
Papadimitriou, K., Alegría, Á., Bron, P. A., de Angelis, M., Gobbetti, M., Kleerebezem, M., Lemos, J. A., Linares, D. M., Ross, P., Stanton, C., et al. (2016) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00076-15 · Cited by 914
Role of Lactobacillus reuteri in Human Health and Diseases
Mu, Q., Tavella, V. J., & Luo, X. M. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00757 · Cited by 744
Metadata
- Authors
- Jones, S. E., & Versalovic, J.
- Venue
- BMC Microbiology
- Published
- 2009
- Volume
- 9
- Issue
- 1
- Pages
- 35
- ISSN
- 1471-2180 (ISSN-L)
- OpenAlex
- W2089612575
- Cited by
- 416
- References
- 3
- FWCI
- 23.35
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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