The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice
Open accessAbstract
Background: ADAM22 is a member of the ADAM gene family, but the fact that it is expressed only in the nervous systems makes it unique. ADAM22's sequence similarity to other ADAMs suggests it to be an integrin binder and thus to have a role in cell-cell or cell-matrix interactions. To elucidate the physiological functions of ADAM22, we employed gene targeting to generate ADAM22 knockout mice. Results: ADAM22-deficient mice were produced in a good accordance with the Mendelian ratio and appeared normal at birth. After one week, severe ataxia was observed, and all homozygotes died before weaning, probably due to convulsions. No major histological abnormalities were detected in the cerebral cortex or cerebellum of the homozygous mutants; however, marked hypomyelination of the peripheral nerves was observed. Conclusion: The results of our study demonstrate that ADAM22 is closely involved in the correct functioning of the nervous system. Further analysis of ADAM22 will provide clues to understanding the mechanisms of human diseases such as epileptic seizures and peripheral neuropathy.
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A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells
Black, R. A., Rauch, C. T., Kozlosky, C. J., Peschon, J. J., Slack, J. L., Wolfson, M. F., Castner, B. J., Stocking, K. L., Reddy, P., Srinivasan, S., et al. (1997) · Nature · doi:10.1038/385729a0 · Cited by 3,149
Chae, T., Kwon, Y. T., Bronson, R., Dikkes, P., Li, E., & Tsai, L.-H. (1997) · Neuron · doi:10.1016/s0896-6273(01)80044-1 · Cited by 715
Functional analysis of secreted and transmembrane proteins critical to mouse development.
Mitchell, K. J., Pinson, K. I., Kelly, O. G., Brennan, J., Zupicich, J., Scherz, P., Leighton, P. A., Goodrich, L. V., Lu, X., Avery, B. J., et al. (2001) · Nature Genetics · doi:10.1038/90074 · Cited by 400
Cited by
Lai, M., Huijbers, M. G., Lancaster, E., Graus, F., Bataller, L., Balice-Gordon, R., Cowell, J. K., & Dalmau, J. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70137-x · Cited by 1,361
EDWARDS, D., HANDSLEY, M., & PENNINGTON, C. (2008) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2008.08.001 · Cited by 1,161
Metalloproteinases: Mediators of Pathology and Regeneration in the CNS
Yong, V. W. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1807 · Cited by 582
Brinkmann, B. G., Agarwal, A., Sereda, M. W., Garratt, A. N., Müller, T., Wende, H., Stassart, R. M., Nawaz, S., Humml, C., Velanac, V., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.028 · Cited by 417
Salzer, J. L. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020529 · Cited by 364
Metadata
- Authors
- Sagane, K., Hayakawa, K., Kai, J., Hirohashi, T., Takahashi, E., Miyamoto, N., Ino, M., Oki, T., Yamazaki, K., & Nagasu, T.
- Venue
- BMC Neuroscience
- Published
- 2005-05-06
- Volume
- 6
- Issue
- 1
- Pages
- 33-33
- ISSN
- 1471-2202 (ISSN-L)
- OpenAlex
- W1756962622
- Cited by
- 174
- References
- 3
- FWCI
- 5.97
- Type
- journal article
- Language
- en
- Open access
- gold
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- Sagane, K., Hayakawa, K., Kai, J., Hirohashi, T., Takahashi, E., Miyamoto, N., Ino, M., Oki, T., Yamazaki, K., & Nagasu, T. (2005). Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice. BMC Neuroscience. https://doi.org/10.1186/1471-2202-6-33
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