The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Schwann Cell Myelination
Open accessAbstract
Myelinated nerve fibers are essential for the rapid propagation of action potentials by saltatory conduction. They form as the result of reciprocal interactions between axons and Schwann cells. Extrinsic signals from the axon, and the extracellular matrix, drive Schwann cells to adopt a myelinating fate, whereas myelination reorganizes the axon for its role in conduction and is essential for its integrity. Here, we review our current understanding of the development, molecular organization, and function of myelinating Schwann cells. Recent findings into the extrinsic signals that drive Schwann cell myelination, their cognate receptors, and the downstream intracellular signaling pathways they activate will be described. Together, these studies provide important new insights into how these pathways converge to activate the transcriptional cascade of myelination and remodel the actin cytoskeleton that is critical for morphogenesis of the myelin sheath.
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Cites
Oligodendroglia metabolically support axons and contribute to neurodegeneration
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Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity
Fünfschilling, U., Supplie, L. M., Mahad, D., Boretius, S., Saab, A. S., Edgar, J., Brinkmann, B. G., Kassmann, C. M., Tzvetanova, I. D., Möbius, W., et al. (2012) · Nature · doi:10.1038/nature11007 · Cited by 1,523
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Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling
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“Recent studies of CNS myelination indicate a surprising amount of ongoing myelination in the adult (Young et al. 2013) and suggest that neural activity and experience may be important regulators of oligodendrocyte myelination (Liu et al.”
Control of Peripheral Nerve Myelination by the ß-Secretase BACE1
Willem, M., Garratt, A. N., Novak, B., Citron, M., Kaufmann, S., Rittger, A., DeStrooper, B., Saftig, P., Birchmeier, C., & Haass, C. (2006) · Science · doi:10.1126/science.1132341 · Cited by 703 · cited 11×
“Unexpectedly, inhibition of myosin II appears to potentiate CNS myelination, indicating that myelination in the PNS and CNS is mechanistically distinct (Wang et al. 2008).”
InfluentialImpaired adult myelination in the prefrontal cortex of socially isolated mice
Liu, J., Dietz, K., DeLoyht, J. M., Pedre, X., Kelkar, D., Kaur, J., Vialou, V., Lobo, M. K., Dietz, D. M., Nestler, E. J., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3263 · Cited by 685
Determinants of conduction velocity in myelinated nerve fibers
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Bace1 modulates myelination in the central and peripheral nervous system
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Identification of long-lived proteins reveals exceptional stability of essential cellular structures
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Cited by
Oligodendrocytes in development, myelin generation and beyond
Kuhn, S., Gritti, L., Crooks, D., & Dombrowski, Y. (2019) · Cells · doi:10.3390/cells8111424 · Cited by 625
Myelin Fat Facts: An Overview of Lipids and Fatty Acid Metabolism
Poitelon, Y., Kopec, A. M., & Belin, S. (2020) · Cells · doi:10.3390/cells9040812 · Cited by 394
The etiology of Bell’s palsy: a review
Zhang, W., Xu, L., Luo, T., Wu, F., Zhao, B., & Li, X. (2020) · Journal of Neurology · doi:10.1007/s00415-019-09282-4 · Cited by 336
Glia in mammalian development and disease
Zuchero, J. B., & Barres, B. A. (2015) · Development · doi:10.1242/dev.129304 · Cited by 304
Jha, M. K., & Morrison, B. M. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.07.009 · Cited by 203
Metadata
- Authors
- Salzer, J. L.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2015-06-08
- Volume
- 7
- Issue
- 8
- Pages
- a020529
- ISSN
- 1943-0264 (ISSN-L)
- OpenAlex
- W2142077499
- Cited by
- 364
- References
- 14
- Type
- posted content
- Language
- en
- Open access
- bronze
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