The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Dendritic mRNAs encode diversified functionalities in hippocampal pyramidal neurons
Open accessAbstract
Background: Targeted transport of messenger RNA and local protein synthesis near the synapse are important for synaptic plasticity. In order to gain an overview of the composition of the dendritic mRNA pool, we dissected out stratum radiatum (dendritic lamina) from rat hippocampal CA1 region and compared its mRNA content with that of stratum pyramidale (cell body layer) using a set of cDNA microarrays. RNAs that have over-representation in the dendritic fraction were annotated and sorted into function groups. Results: We have identified 154 dendritic mRNA candidates, which can be arranged into the categories of receptors and channels, signaling molecules, cytoskeleton and adhesion molecules, and factors that are involved in membrane trafficking, in protein synthesis, in posttranslational protein modification, and in protein degradation. Previously known dendritic mRNAs such as MAP2, calmodulin, and G protein gamma subunit were identified from our screening, as were mRNAs that encode proteins known to be important for synaptic plasticity and memory, such as spinophilin, Pumilio, eEF1A, and MHC class I molecules. Furthermore, mRNAs coding for ribosomal proteins were also found in dendrites. Conclusion: Our results suggest that neurons transport a variety of mRNAs to dendrites, not only those directly involved in modulating synaptic plasticity, but also others that play more common roles in cellular metabolism.
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Cites
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Functional requirement for class I MHC in CNS development and plasticity
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Ribosomal S6 Kinase Signaling and the Control of Translation
Dufner, A., & Thomas, G. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4683 · Cited by 676 · cited 1×
“Finally, we have an mRNA encoding S6 kinase, which could also be appropriately assigned to the next functional group of RNA translational regulators [28].”
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“Local translation of dendritic mRNAs is modulated by synaptic activities [2-8].”
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Regulation of Synaptic Strength by Protein Phosphatase 1
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Cited by
Dendritic Protein Synthesis, Synaptic Plasticity, and Memory
Sutton, M. A., & Schuman, E. M. (2006) · Cell · doi:10.1016/j.cell.2006.09.014 · Cited by 888
Kosik, K. S. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn2037 · Cited by 826
Cajigas, I. J., Tushev, G., Will, T. J., tom Dieck, S., Fuerst, N., & Schuman, E. M. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.036 · Cited by 709
The Central Dogma Decentralized: New Perspectives on RNA Function and Local Translation in Neurons
Holt, C. E., & Schuman, E. M. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.036 · Cited by 525
Local protein synthesis is a ubiquitous feature of neuronal pre- and postsynaptic compartments
Hafner, A.-S., Donlin-Asp, P. G., Leitch, B., Herzog, E., & Schuman, E. M. (2019) · Science · doi:10.1126/science.aau3644 · Cited by 431
Metadata
- Authors
- Zhong, J., Zhang, T., & Bloch, L. M.
- Venue
- BMC Neuroscience
- Published
- 2006-02-17
- Volume
- 7
- Issue
- 1
- Pages
- 17-17
- ISSN
- 1471-2202 (ISSN-L)
- OpenAlex
- W1818286516
- Cited by
- 165
- References
- 8
- FWCI
- 5.09
- Type
- journal article
- Language
- en
- Open access
- gold
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