The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Against quantiles: categorization of continuous variables in epidemiologic research, and its discontents
Open accessAbstract
BACKGROUND: Quantiles are a staple of epidemiologic research: in contemporary epidemiologic practice, continuous variables are typically categorized into tertiles, quartiles and quintiles as a means to illustrate the relationship between a continuous exposure and a binary outcome. DISCUSSION: In this paper we argue that this approach is highly problematic and present several potential alternatives. We also discuss the perceived drawbacks of these newer statistical methods and the possible reasons for their slow adoption by epidemiologists. SUMMARY: The use of quantiles is often inadequate for epidemiologic research with continuous variables.
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Cites
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Vickers, A. J., Bianco, F. J., Serio, A. M., Eastham, J. A., Schrag, D., Klein, E. A., Reuther, A. M., Kattan, M. W., Pontes, J. E., & Scardino, P. T. (2007) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djm060 · Cited by 402
Self-citationGreenland, S. (1995) · Epidemiology · doi:10.1097/00001648-199507000-00025 · Cited by 360
The surgical learning curve for laparoscopic radical prostatectomy: a retrospective cohort study
Vickers, A. J., Savage, C. J., Hruza, M., Tuerk, I., Koenig, P., Martínez-Piñeiro, L., Janetschek, G., & Guillonneau, B. (2009) · The Lancet Oncology · doi:10.1016/s1470-2045(09)70079-8 · Cited by 289
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Cited by
Moons, K. G. M., Altman, D. G., Reitsma, J. B., Ioannidis, J. P. A., Macaskill, P., Steyerberg, E. W., Vickers, A. J., Ransohoff, D. F., & Collins, G. S. (2015) · Annals of Internal Medicine · doi:10.7326/m14-0698 · Cited by 5,147
Self-citationMoons, K. G. M., de Groot, J. A. H., Bouwmeester, W., Vergouwe, Y., Mallett, S., Altman, D. G., Reitsma, J. B., & Collins, G. S. (2014) · PLoS Medicine · doi:10.1371/journal.pmed.1001744 · Cited by 2,018
“Continuous or categorical predictors are frequently dichotomised for the analysis [2,42,56,60,78] despite strong evidence and recommendations to the contrary [92–94].”
BackgroundLiu, T.-Z., Xu, C., Rota, M., Cai, H., Zhang, C., Shi, M.-J., Yuan, R.-X., Weng, H., Meng, X.-Y., Kwong, J. S. W., et al. (2017) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2016.02.005 · Cited by 302
Collins, G. S., Ogundimu, E. O., Cook, J. A., Manach, Y. L., & Altman, D. G. (2016) · Statistics in Medicine · doi:10.1002/sim.6986 · Cited by 185
Schuster, N. A., Rijnhart, J. J. M., Twisk, J. W. R., & Heymans, M. W. (2022) · Frontiers in Epidemiology · doi:10.3389/fepid.2022.975380 · Cited by 125
Metadata
- Authors
- Bennette, C., & Vickers, A.
- Venue
- BMC Medical Research Methodology
- Published
- 2012-02-29
- Volume
- 12
- Issue
- 1
- Pages
- 21-21
- ISSN
- 1471-2288 (ISSN-L)
- OpenAlex
- W1965855329
- Cited by
- 444
- References
- 16
- FWCI
- 13.48
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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