Cited by 1,299Statistical Methods in Clinical TrialsMeta-analysis and systematic reviewsStatistical Methods in Epidemiology

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Do multiple outcome measures require p-value adjustment?

Open access

Feise, Ronald J·2002·BMC Medical Research Methodology

DOI 10.1186/1471-2288-2-8PMC PMC117123

Open this paper in CoChat — free account Open PDF

Abstract

BACKGROUND: Readers may question the interpretation of findings in clinical trials when multiple outcome measures are used without adjustment of the p-value. This question arises because of the increased risk of Type I errors (findings of false "significance") when multiple simultaneous hypotheses are tested at set p-values. The primary aim of this study was to estimate the need to make appropriate p-value adjustments in clinical trials to compensate for a possible increased risk in committing Type I errors when multiple outcome measures are used. DISCUSSION: The classicists believe that the chance of finding at least one test statistically significant due to chance and incorrectly declaring a difference increases as the number of comparisons increases. The rationalists have the following objections to that theory: 1) P-value adjustments are calculated based on how many tests are to be considered, and that number has been defined arbitrarily and variably; 2) P-value adjustments reduce the chance of making type I errors, but they increase the chance of making type II errors or needing to increase the sample size. SUMMARY: Readers should balance a study's statistical significance with the magnitude of effect, the quality of the study and with findings from other studies. Researchers facing multiple outcome measures might want to either select a primary outcome measure or use a global assessment measure, rather than adjusting the p-value.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1186/1471-2288-2-8

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A Simple Sequentially Rejective Multiple Test Procedure
(1979) · Scandinavian Journal of Statistics · doi:10.2307/4615733 · Cited by 21,526
No adjustments are needed for multiple comparisons.
Rothman, K. J. (1990) · Epidemiology · doi:10.1097/00001648-199001000-00010 · Cited by 5,965
What's wrong with Bonferroni adjustments
Perneger, T. V. (1998) · BMJ · doi:10.1136/bmj.316.7139.1236 · Cited by 5,900
Multiple significance tests: the Bonferroni method
Bland, J. M., & Altman, D. G. (1995) · BMJ · doi:10.1136/bmj.310.6973.170 · Cited by 3,341
Rectangular Confidence Regions for the Means of Multivariate Normal Distributions
Šidák, Z. (1967) · Journal of the American Statistical Association · doi:10.1080/01621459.1967.10482935 · Cited by 2,904
An improved Bonferroni procedure for multiple tests of significance
SIMES, R. J. (1986) · Biometrika · doi:10.1093/biomet/73.3.751 · Cited by 2,396
Multiple Comparison Procedures
Hahs-Vaughn, D., & Lomax, R. (2013) · Routledge eBooks · doi:10.4324/9780203137819-17 · Cited by 2,132
A Stagewise Rejective Multiple Test Procedure Based on a Modified Bonferroni Test
Hommel, G. (1988) · Biometrika · doi:10.1093/biomet/75.2.383 · Cited by 1,367
Adjusting for multiple testing when reporting research results: the Bonferroni vs Holm methods.
Aickin, M., & Gensler, H. (1996) · American Journal of Public Health · doi:10.2105/ajph.86.5.726 · Cited by 1,346
ON THE USE AND INTERPRETATION OF CERTAIN TEST CRITERIA FOR PURPOSES OF STATISTICAL INFERENCE
Neyman, J., & Pearson, E. S. (1928) · Biometrika · doi:10.1093/biomet/20a.3-4.263 · Cited by 1,164

Show all 42 references

Sorted by citations

Items 501–600 of 1,000

Impact of a blended web-based mindfulness programme for general practitioners: a pilot study
Montero-Marin, J., Gaete, J., Araya, R., Demarzo, M., Manzanera, R., Álvarez de Mon, M., & García-Campayo, J. (2018) · Mindfulness · doi:10.1007/s12671-017-0752-8 · Cited by 22
The Monocyte-to-Lymphocyte Ratio Correlates with Psycho-Neuro-Inflammatory Factors in Patients with Stable Coronary Artery Disease
Serfőző, G., Horváth, T., Földesi, I., Rafael, B., von Känel, R., & Keresztes, M. (2016) · NeuroImmunoModulation · doi:10.1159/000443835 · Cited by 21
Expression Profiling of Nonpolar Lipids in Meibum From Patients With Dry Eye: A Pilot Study
Chen, J., Keirsey, J. K., Green, K. B., & Nichols, K. K. (2017) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-20902 · Cited by 21
Correlates and Predictors of Virginity Among Heterosexual African American Young Adults
Landor, A. M., & Simons, L. G. (2019) · Sexuality & Culture · doi:10.1007/s12119-019-09600-y · Cited by 22
Initial studies of the phenotype and persistence of speech motor delay (SMD)
Shriberg, L. D., Campbell, T. F., Mabie, H. L., & McGlothlin, J. H. (2019) · Clinical Linguistics & Phonetics · doi:10.1080/02699206.2019.1595733 · Cited by 22
Automatic Nonverbal Mimicry Detection and Analysis in Medical Video Consultations
Wu, K., Liu, C., & Calvo, R. A. (2020) · International Journal of Human-Computer Interaction · doi:10.1080/10447318.2020.1752474 · Cited by 20
Cats vs. Dogs: The Efficacy of Feliway FriendsTM and AdaptilTM Products in Multispecies Homes
Prior, M. R., & Mills, D. S. (2020) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.00399 · Cited by 21
Implementing a training program to promote mindful, empathic, and pro-environmental attitudes in the classroom: a controlled exploratory study with elementary school students
Jalón, C., Montero‐Marín, J., Modrego‐Alarcón, M., Gascón, S., Navarro‐Gil, M., Barceló‐Soler, A., Delgado-Suárez, I., & García‐Campayo, J. (2020) · Current Psychology · doi:10.1007/s12144-020-00962-3 · Cited by 27
Angiotensin II receptor blocker or angiotensin-converting enzyme inhibitor use and COVID-19-related outcomes among US Veterans
Derington, C. G., Cohen, J. B., Mohanty, A. F., Greene, T., Cook, J. R., Ying, J., Wei, G., Herrick, J. S., Stevens, V. W., Jones, B. E., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0248080 · Cited by 21
Effects of an external compared to an internal focus of attention on the excitability of fast and slow(er) motor pathways
Kuhn, Y., Keller, M. B., Egger, S., & Taube, W. (2021) · Scientific Reports · doi:10.1038/s41598-021-97168-9 · Cited by 21
Longitudinal Effects of a Motivationally Focused Strategy to Increase the Yield of Training and Consultation on Teachers’ Adoption and Fidelity of a Universal Program
Merle, J. L., Cook, C. R., Pullmann, M. D., Larson, M. F., Hamlin, C., Hugh, M. L., Brewer, S. K., Duong, M. T., Bose, M., & Lyon, A. R. (2022) · School Mental Health · doi:10.1007/s12310-022-09536-z · Cited by 23
Multivariate GWAS of Alzheimer’s disease CSF biomarker profiles implies GRIN2D in synaptic functioning
Neumann, A., Ohlei, O., Küçükali, F., Bos, I., Timsina, J., Vos, S. J. B., Prokopenko, D., Tijms, B. M., Andréasson, U., Blennow, K., et al. (2023) · Genome Medicine · doi:10.1186/s13073-023-01233-z · Cited by 22
Obesity Is Associated with Oxidative Stress Markers and Antioxidant Enzyme Activity in Mexican Children
Magaña, A. I. C., Vázquez‐Moreno, M. A., Rocha-Aguado, A., Mejía, S. Á., Valladares‐Salgado, A., Díaz-Flores, M., López‐Díazguerrero, N. E., & Cruz, M. (2024) · Antioxidants · doi:10.3390/antiox13040457 · Cited by 22
Agreement Between self- vs Parent-Ratings of General Anxiety Disorder Symptoms and Salivary Cortisol in boys with an ASD
Bitsika, V., Sharpley, C. F., Andronicos, N. M., & Agnew, L. L. (2015) · Journal of Developmental and Physical Disabilities · doi:10.1007/s10882-015-9431-7 · Cited by 21
Usability of the SAFEWAY2SCHOOL system in children with cognitive disabilities
Falkmer, T., Horlin, C., Dahlman, J., Dükic, T., Barnett, T., & Anund, A. (2013) · European Transport Research Review · doi:10.1007/s12544-013-0117-x · Cited by 21
Different associations between body composition and alcohol when assessed by exposure frequency or by quantitative estimates of consumption
Lean, M. E. J., Vlachou, P., Govan, L., & Han, T. S. (2018) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12583 · Cited by 21
Withdrawal Symptoms From E-Cigarette Abstinence Among Former Smokers: A Pre-Post Clinical Trial.
Hughes, J., Peters, E. N., Callas, P., Peasley-Miklus, C., Oga, E., Etter, J., & Morley, N. (2019) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntz129 · Cited by 18
Opening a Large Delivery Service Warehouse in the South Bronx: Impacts on Traffic, Air Pollution, and Noise
Shearston, J. A., Johnson, A. M., Domingo‐Relloso, A., Kioumourtzoglou, M., Hernández, D., Ross, J., Chillrud, S. N., & Hilpert, M. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17093208 · Cited by 21
Prevention, diagnosis and management of chemotherapy-induced peripheral neuropathy: a cross-sectional study of French oncologists’ professional practices
Selvy, M., Pereira, B., Kerckhove, N., Busserolles, J., Farsi, F., Guastella, V., Merle, P., Pezet, D., & Balayssac, D. (2021) · Supportive Care in Cancer · doi:10.1007/s00520-020-05928-6 · Cited by 24
Anxiety in 3- to 7-year-old children with autism spectrum disorder seeking treatment for disruptive behavior
Sukhodolsky, D. G., Lecavalier, L., Johnson, C. R., Smith, T. H., Swiezy, N. B., Bearss, K. E., Kalvin, C. B., & Scahill, L. D. (2019) · Autism · doi:10.1177/1362361319866561 · Cited by 21
Effectiveness of robotic assisted rehabilitation for mobility and functional ability in adult stroke patients: a systematic review protocol
Lo, K., Stephenson, M., & Lockwood, C. S. (2017) · The JBI Database of Systematic Reviews and Implementation Reports · doi:10.11124/jbisrir-2016-002957 · Cited by 21
Microarray test results should not be compensated for multiplicity of gene contents
Konishi, T. (2011) · BMC Systems Biology · doi:10.1186/1752-0509-5-s2-s6 · Cited by 21
MicroRNA-related polymorphisms in pseudoexfoliation syndrome, pseudoexfoliative glaucoma, and primary open-angle glaucoma
Chatzikyriakidou, A., Founti, P., Melidou, A., Minti, F., Bouras, E., Anastasopoulos, E., Pappas, T., Haidich, A., Lambropoulos, A. F., & Topouzis, F. (2018) · Ophthalmic Genetics · doi:10.1080/13816810.2018.1509352 · Cited by 21
Relationships of inflamm-aging with circulating nutrient levels, body composition, age, and pituitary pars intermedia dysfunction in a senior horse population
Siard, M. H., Harris, P. A., Moffett-Krotky, A. D., Ireland, J. L., Betancourt, A., Barker, V. D., McMurry, K. E., Reedy, S. E., & Adams, A. A. (2020) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2020.110013 · Cited by 20
Associations Between Antidepressant Use and Advanced Diabetes Outcomes in Patients with Depression and Diabetes Mellitus
Wu, C., Hsu, L., Pan, Y., & Wang, S. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab443 · Cited by 22
El Niño and marine heatwaves: Ecological impacts on Oregon rocky intertidal kelp communities at local to regional scales
Spiecker, B. J., & Menge, B. A. (2022) · Ecological Monographs · doi:10.1002/ecm.1504 · Cited by 21
Perspective Chapter: Interdisciplinary Pain Rehabilitation Programs – Evidence and Clinical Real-World Results
Gerdle, B. U. C., Fischer, M. R., & Ringqvist, Å. (2022) · Pharmaceutical science. · doi:10.5772/intechopen.102411 · Cited by 21
Concomitant fibromyalgia in primary Sjögren's syndrome in the French ASSESS cohort: comparison of the ACR 1990 and ACR 2016 criteria, FiRST questionnaire and physician's opinion
Dubost, J., Couderc, M., Pereira, B., Mariette, X., Séror, R., Gottenberg, J., HACHULLA, E., Guern, V. L., Saraux, A., Morel, J., et al. (2021) · Clinical and Experimental Rheumatology · doi:10.55563/clinexprheumatol/uxlsh3 · Cited by 20
The link between cognitive and affective empathy and interpersonal emotion regulation direction and strategies
Chavira-Trujillo, G., Tomás, M. G., & López‐Pérez, B. (2022) · Scandinavian Journal of Psychology · doi:10.1111/sjop.12847 · Cited by 25
Aldose reductase inhibition decelerates optic nerve degeneration by alleviating retinal microglia activation
Rao, M., Huang, Y., Liu, C.-C., Meadows, C., Cheng, H.-C., Zhou, M., Chen, Y., Xia, X., Goldberg, J. L., Williams, A. M., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-32702-5 · Cited by 23
Prenatal bisphenol exposure and intelligence quotient in children at six years of age: A prospective cohort study
Chen, Y., Miao, M., Wang, Z., Ji, H., Zhou, Y., Liang, H., He, G., & Yuan, W. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.139023 · Cited by 20
School-based universal mental health promotion intervention for adolescents in Vietnam: Two-arm, parallel, controlled trial
Tran, T. D., Nguyen, H. T., Shochet, I. M., Nguyen, N. T., La, N., Wurfl, A. M., Orr, J. A., Nguyen, H. T. M., Stocker, R., & Fisher, J. (2023) · Cambridge Prisms Global Mental Health · doi:10.1017/gmh.2023.66 · Cited by 23
Metabolic Status Influences Probiotic Efficacy for Depression—PRO-DEMET Randomized Clinical Trial Results
Gawlik-Kotelnicka, O., Margulska, A., Płeska, K., Skowrońska, A., & Strzelecki, D. (2024) · Nutrients · doi:10.3390/nu16091389 · Cited by 24
Muscle contributions to centre of mass acceleration during turning gait in typically developing children: A simulation study
Dixon, P. C., Jansen, K., Jonkers, I., Stebbins, J., Theologis, T. N., & Zavatsky, A. B. (2015) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2015.10.028 · Cited by 20
Anthroposophic therapy for children with chronic disease: a two-year prospective cohort study in routine outpatient settings
Hamre, H. J., Witt, C. M., Kienle, G. S., Meinecke, C., Glockmann, A., Willich, S. N., & Kiene, H. (2009) · BMC Pediatrics · doi:10.1186/1471-2431-9-39 · Cited by 20
Predicting Successful 24-Hr Quit Attempt in a Smoking Cessation Intervention
Bailey, S. R., Bryson, S. W., & Killen, J. D. (2011) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntr151 · Cited by 20
Do personality traits affect responsiveness of juvenile delinquents to treatment?
Asscher, J. J., Deković, M., van den Akker, A. L., Manders, W. A., Prins, P. J. M., van der Laan, P. H., & Prinzie, P. (2016) · Journal of Research in Personality · doi:10.1016/j.jrp.2016.05.004 · Cited by 22
Interaction of sex steroid hormones and obesity on insulin resistance and type 2 diabetes in men: the Third National Health and Nutrition Examination Survey
Li, J., Lai, H. C., Chen, S., Zhu, H., & Lai, S. (2016) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2016.10.022 · Cited by 19
Neurocognitive assessment of emotional context sensitivity
Myruski, S., Bonanno, G. A., Gulyayeva, O., Egan, L. J., & Dennis‐Tiwary, T. A. (2017) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-017-0533-9 · Cited by 21
Management of type 2 diabetes mellitus in people with severe mental illness: an online cross-sectional survey of healthcare professionals
McBain, H. B., Lamontagne-Godwin, F., Haddad, M., Simpson, A., Chapman, J., Jones, J., Flood, C., & Mulligan, K. (2018) · BMJ Open · doi:10.1136/bmjopen-2017-019400 · Cited by 23
Prognostic significance of tumor genotypes and CD8+ infiltrates in stage I-III colorectal cancer
Fountzilas, E., Kotoula, V., Tikas, I. S., Manousou, K., Papadopoulou, K., Poulios, C., Karavasilis, V., Efstratiou, I., Pectasides, D. G., Papaparaskeva, K., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.26256 · Cited by 21
Perceived Workplace Experiences of Adapted Physical Educators and Physical Educators
Wilson, W. J., Richards, K. A. R., Haegele, J. A., & Holland, S. K. (2020) · Research Quarterly for Exercise and Sport · doi:10.1080/02701367.2019.1694632 · Cited by 20
Prognostic implications of adaptive immune features in MMR-proficient colorectal liver metastases classified by histopathological growth patterns
Messaoudi, N., Henault, D., Stephen, D., Cousineau, I., Simoneau, È., Rong, Z., Letourneau, R., Plasse, M., Dagenais, M., Roy, A., et al. (2022) · British Journal of Cancer · doi:10.1038/s41416-021-01667-5 · Cited by 20
Test-Retest Reliability of Distortion Product Otoacoustic Emissions in the 1 to 7 kHz Range
Ng, I. H.-Y., & McPherson, B. (2005) · Hearing Balance and Communication · doi:10.1080/16513860510028284 · Cited by 20
Behavioral Impact of Unisensory and Multisensory Audio-Tactile Events: Pros and Cons for Interlimb Coordination in Juggling
Zelic, G., Mottet, D., & Lagarde, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032308 · Cited by 22
Variation in Muscle Activity Among Office Workers When Using Different Information Technologies at Work and Away From Work
Ciccarelli, M., Straker, L. M., Mathiassen, S. E., & Pollock, C. M. (2013) · Human Factors The Journal of the Human Factors and Ergonomics Society · doi:10.1177/0018720813485788 · Cited by 20
Effects of consuming a high‐protein diet with or without soy protein during weight loss and maintenance: a non‐inferiority, randomized clinical efficacy trial
Speaker, K. J., Sayer, R. D., Peters, J. C., Foley, H. N., Pan, Z., Wyatt, H. R., Flock, M. R., Mukherjea, R., & Hill, J. O. (2018) · Obesity Science & Practice · doi:10.1002/osp4.278 · Cited by 19
Do p Values Lose Their Meaning in Exploratory Analyses? It Depends How You Define the Familywise Error RatePreprint
Rubin, M. (2017) · PsyArXiv (OSF Preprints) · doi:10.31234/osf.io/gn8aq · Cited by 22
Self-Perception and Self-Acceptance Are Related to Unhealthy Weight Control Behaviors in Catalan Adolescents: A Cross-Sectional Study
Pollina-Pocallet, M., Artigues-Barberà, E., Tort‐Nasarre, G., Sol, J., Azlor, L., Boreu, Q. F., & Ortega, M. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18094976 · Cited by 22
Motivations to Change Smoking Behaviors Between 2007 and 2019 in Australia: A Repeated Cross-sectional Study
Cho, A., Chan, G., & GARTNER, C. E. (2022) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntac176 · Cited by 19
Repeated nitrous oxide exposure in rats causes a thermoregulatory sign-reversal with concurrent activation of opposing thermoregulatory effectors
Ramsay, D. S., Woods, S. C., & Kaiyala, K. J. (2014) · Temperature · doi:10.4161/23328940.2014.944809 · Cited by 19
The Multimodal Assessment of Adult Attachment Security: Developing the Biometric Attachment Test
Parra, F., Miljkovitch, R., Persiaux, G., Morales, M. R., & Scherer, S. J. (2017) · Journal of Medical Internet Research · doi:10.2196/jmir.6898 · Cited by 19
Learning and CRF-Induced Indecision during Escape and Submission in Rainbow Trout during Socially Aggressive Interactions in the Stress-Alternatives Model
Summers, T. R., Summers, T. L., Carpenter, R. E., Smith, J. P., Young, S. L., Meyerink, B. L., Orr, T. Z., Arendt, D. H., & Summers, C. H. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00515 · Cited by 19
Psychological effects of belonging to a Facebook weight management group in overweight and obese adults: Results of a randomised controlled trial
Jane, M., Foster, J. K., Hagger, M. S., Ho, S. S., Kane, R. T., & Pal, S. (2018) · Health & Social Care in the Community · doi:10.1111/hsc.12584 · Cited by 20
Older Adults' Sedentary Behavior and Physical Activity After Hip Fracture: Results From an Outpatient Rehabilitation Randomized Controlled Trial
Zusman, E. Z., Dawes, M. G., Fleig, L., McAllister, M. M., Cook, W. L., Guy, P., Brasher, P. M. A., McKay, H. A., Khan, K. M., & Ashe, M. C. (2018) · Journal of Geriatric Physical Therapy · doi:10.1519/jpt.0000000000000193 · Cited by 19
Students' behavioural engagement in reviewing their tele-consultation feedback within an online clinical communication skills platform
Liu, C., Lim, R., Taylor, S., & Calvo, R. A. (2019) · Computers in Human Behavior · doi:10.1016/j.chb.2019.01.002 · Cited by 19
Testing the effects of a pilot listening comprehension and vocabulary intervention for individuals with autism
Solari, E., Henry, A., McIntyre, N., Grimm, R. P., & Zajic, M. (2020) · Research in Autism · doi:10.1016/j.rasd.2019.101501 · Cited by 17
Perceived Competence, Achievement Goals, and Return-To-Sport Outcomes: A Mediation Analysis
D’Astous, E., Podlog, L. W., Burns, R. D., Newton, M., & Fawver, B. J. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17092980 · Cited by 19
The effectiveness of COVID-related message framing on public beliefs and behaviors related to plant-based diets
Niemiec, R., Jones, M. S., Mertens, A., & Dillard, C. (2021) · Appetite · doi:10.1016/j.appet.2021.105293 · Cited by 17
Pharmaceutical opioid poisonings in Victoria, Australia: Rates and characteristics of a decade of emergency department presentations among nine pharmaceutical opioids
Lam, T., Hayman, J., Berecki‐Gisolf, J., Sanfilippo, P. G., Lubman, D. I., & Nielsen, S. (2021) · Addiction · doi:10.1111/add.15653 · Cited by 18
Association between the APOB rs1469513 polymorphism and obesity is modified by dietary fat intake in Koreans
Doo, M., Won, S., & Kim, Y. (2014) · Nutrition · doi:10.1016/j.nut.2014.10.007 · Cited by 19
Evolution and ecology meet molecular genetics: adaptive phenotypic plasticity in two isolated Negev desert populations of Acacia raddiana at either end of a rainfall gradient
Ward, D., Shrestha, M. K., & Golan‐Goldhirsh, A. (2011) · Annals of Botany · doi:10.1093/aob/mcr276 · Cited by 22
Prognostic Value of Serum Caspase-Cleaved Cytokeratin-18 Levels before Liver Transplantation for One-Year Survival of Patients with Hepatocellular Carcinoma
Lorente, L., Rodriguez, S., Sanz, P., Pérez-Cejas, A., Padilla, J., Díaz, D., González, A., Martı́n, M., Jiménez, A., & Barrera, M. A. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17091524 · Cited by 18
Evaluation of a Health Communication Campaign to Improve Mosquito Awareness and Prevention Practices in Western Australia
Potter, A. S., Jardine, A., Morrissey, A., & LINDSAY, M. D. A. (2019) · Frontiers in Public Health · doi:10.3389/fpubh.2019.00054 · Cited by 18
Post-moderate-intensity exercise energy replacement does not reduce subsequent appetite and energy intake in adolescents with obesity
Thivel, D., Roche, J., Miguet, M., Fillon, A., Khammassi, M., Beaulieu, K., Finlayson, G., Pereira, B., Miyashita, M., Thackray, A. E., et al. (2019) · British Journal Of Nutrition · doi:10.1017/s0007114519003106 · Cited by 18
Leveraging self-determination theory to understand which preschool teachers benefit most from a professional development intervention
Bayly, B. L., Dizon, E., Shrestha, G., Smith, C. L., Tekle, S., & Cooper, B. R. (2020) · Journal of Early Childhood Teacher Education · doi:10.1080/10901027.2020.1818652 · Cited by 24
Wideband absorbance pattern in adults with otosclerosis and ossicular chain discontinuity
Karuppannan, A., & Barman, A. (2020) · Auris Nasus Larynx · doi:10.1016/j.anl.2020.10.019 · Cited by 18
Serendipity in the city: User evaluations of urban recommender systems
Smets, A., Vannieuwenhuyze, J., & Ballon, P. (2021) · Journal of the Association for Information Science and Technology · doi:10.1002/asi.24552 · Cited by 18
Investigating the synergistic effects of hormone replacement therapy, apolipoprotein E and age on brain health in the UK Biobank
Ambikairajah, A., Khondoker, M. R., Morris, E., de Lange, A. G., Saleh, R. N. M., Minihane, A. M., & Hornberger, M. (2024) · Human Brain Mapping · doi:10.1002/hbm.26612 · Cited by 17
The Farage Quality of Life Measure for Consumer Products: Development and Initial Implementation
Farage, M. A., Nusair, T. L., Hanseman, D. J., Sherman, S. N., & Tsevat, J. (2009) · Applied Research in Quality of Life · doi:10.1007/s11482-009-9087-5 · Cited by 18
Genetically predicted testosterone and electrocardiographic QT interval duration in Chinese: a Mendelian randomization analysis in the Guangzhou Biobank Cohort Study
Zhao, J. V., Jiang, C., Lam, T., Liu, B., Cheng, K. K., Xu, L., Long, M. J., Zhang, W., Leung, G. M., & Schooling, C. M. (2014) · International Journal of Epidemiology · doi:10.1093/ije/dyu241 · Cited by 18
Role of neurotrophins in depressive symptoms and executive function: Association analysis of NRN1 gene and its interaction with BDNF gene in a non-clinical sample
Prats, C., Arias, B., Ortet, G., Ibáñez, M. I., Moya-Higueras, J., Pomarol‐Clotet, E., Fañanás, L., & Fatjó‐Vilas, M. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.11.017 · Cited by 23
Jigsaw Puzzles As Cognitive Enrichment (PACE) - the effect of solving jigsaw puzzles on global visuospatial cognition in adults 50 years of age and older: study protocol for a randomized controlled trial
Fissler, P., Küster, O. C., Loy, L. S., Laptinskaya, D., Rosenfelder, M. J., Arnim, C. A. F. V., & Kolassa, I. (2017) · Trials · doi:10.1186/s13063-017-2151-9 · Cited by 26
Between-Leg Mechanical Differences as Measured by the Bulgarian Split-Squat: Exploring Asymmetries and Relationships with Sprint Acceleration
Lockie, R. G., Risso, F. G., Lazar, A., Giuliano, D. V., Stage, A. A., Liu, T. M., Beiley, M. D., Hurley, J. M., Torne, I. A., Stokes, J., et al. (2017) · Sports · doi:10.3390/sports5030065 · Cited by 18
Semantic Features Reveal Different Networks During Word Processing: An EEG Source Localization Study
Hnazaee, M. F., Khachatryan, E., & Hulle, M. M. V. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00503 · Cited by 18
Morningness–eveningness and affect: the mediating roles of sleep quality and metacognitive beliefs
Carciofo, R. (2019) · Sleep and Biological Rhythms · doi:10.1007/s41105-019-00238-9 · Cited by 1
Comparing rates and characteristics of ambulance attendances related to extramedical use of pharmaceutical opioids in Victoria, Australia from 2013 to 2018
Nielsen, S., Crossin, R., Middleton, M., Lam, T., Wilson, J., Scott, D. A., Martin, C., Smith, K. L., & Lubman, D. I. (2019) · Addiction · doi:10.1111/add.14896 · Cited by 18
Sarcopenia in patients after an episode of acute decompensated heart failure: An underdiagnosed problem with serious impact
Eschalier, R., Massoullié, G., Boirie‌, Y., Blanquet, M., Mulliez, A., Tartière, P.-L., Anker, S. D., Boiteux, M.-C. D., Richard, R., Jean, F., et al. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2020.12.033 · Cited by 18
Correlation between impedance spectroscopy and bubble-induced mass transport in the electrochemical reduction of carbon dioxide
Lettieri, S., Zeng, J., Farkhondehfal, M. A., Savino, U., Fontana, M., Pirri, C. F., & Sacco, A. (2021) · Journal of Energy Chemistry · doi:10.1016/j.jechem.2021.10.023 · Cited by 19
Anthroposophic therapy for asthma: A two-year prospective cohort study in routine outpatient settings
Hamre, H. J. (2009) · Journal of Asthma and Allergy · doi:10.2147/jaa.s7184 · Cited by 18
EyeFrame: real-time memory aid improves human multitasking via domain-general eye tracking procedures
Taylor, P. (2015) · Frontiers in ICT · doi:10.3389/fict.2015.00017 · Cited by 18
Anthroposophic therapy for attention deficit hyperactivity: A two-year prospective study in outpatients
Hamre, H. J., Witt, C. M., Kienle, G. S., Meinecke, C., Ziegler, R., Glockmann, A., Willich, S. N., & Kiene, H. (2010) · International Journal of General Medicine · doi:10.2147/ijgm.s11725 · Cited by 18
Effect of dehydroepiandrosterone add-on therapy on mood, decision making and subsequent relapse of polydrug users
Ohana, D., Maayan, R., Delayahu, Y., Roska, P., Ponizovsky, A. M., Weizman, A., Yadid, G., & Yechiam, E. (2015) · Addiction Biology · doi:10.1111/adb.12241 · Cited by 18
Trunk and hip electromyographic activity during single leg squat exercises do sex differences exist?
Bolgla, L. A., Cook, N., Hogarth, K., Scott, J., & West, C. (2014) · Europe PMC (PubMed Central) · Cited by 18
Early Intervention and Postural Adjustments During Reaching in Infants at Risk of Cerebral Palsy
van Balen, L. C., Dijkstra, L., Dirks, T., Bos, A. F., & Hadders‐Algra, M. (2019) · Pediatric Physical Therapy · doi:10.1097/pep.0000000000000585 · Cited by 18
Dextromethorphan and memantine after ketamine analgesia: a randomized control trial
Martin, E., Sorel, M., Morel, V., Marcaillou, F., Picard, P., Delage, N., Tiberghien-Chatelain, F., Crosmary, M.-C., Najjar, M., Colamarino, R., et al. (2019) · Drug Design Development and Therapy · doi:10.2147/dddt.s207350 · Cited by 18
Long-Term Evolution of Quality of Life and Symptoms Following Surgical Treatment for Endometriosis: Different Trajectories for Which Patients?
Comptour, A., Lambert, C., Chauvet, P., Figuier, C., Grémeau, A., Canis, M. J., Pereira, B., & Bourdel, N. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9082461 · Cited by 17
Understanding the differential effect of local socio‐economic conditions on the relation between prescription opioid supply and drug overdose deaths in US counties
Fink, D. S., Keyes, K. M., Branas, C. C., Cerdá, M., Gruenewald, P. J., & Hasin, D. S. (2023) · Addiction · doi:10.1111/add.16123 · Cited by 21
Can an Aerobic Exercise Programme Improve the Response of the Growth Hormone in Fibromyalgia Patients? A Randomised Controlled Trial
Marcén, N. C. E., Seral, J. C., Montero‐Marín, J., & Serrano-Ostáriz, E. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20032261 · Cited by 19
Identification of Transporter Polymorphisms Influencing Metformin Pharmacokinetics in Healthy Volunteers
Saiz‐Rodríguez, M., Ochoa, D., Zubiaur, P., Navares‐Gómez, M., Román, M. C., Camargo-Mamani, P., Bueno, S. L., Villapalos‐García, G., Alcaraz, R., Mejía-Abril, G. P., et al. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13030489 · Cited by 17
Calling attention to opponents of climate action in climate and health messaging
Kotcher, J., Luong, K. T., Charles, J., Gould, R., & Maibach, E. W. (2023) · The Lancet Planetary Health · doi:10.1016/s2542-5196(23)00217-6 · Cited by 19
A Randomized Controlled Trial of Unresisted vs. Heavy Resisted Sprint Training Programs: Effects on Strength, Jump, Unresisted and Resisted Sprint Performance in Youth Rugby Union Players
Zabaloy, S., Healy, R., Pereira, L. A., Tondelli, E., Tomaghelli, L., Aparicio, J., Vega, F., Medrano, J., Giráldez, J. C., Comyns, T. M., et al. (2025) · Journal of Human Kinetics · doi:10.5114/jhk/200121 · Cited by 17
Perceptions of Sensitive Skin of the Genital Area
Farage, M. A. (2011) · Current problems in dermatology · doi:10.1159/000321066 · Cited by 17
Alcohol‐related crime in city entertainment precincts: Public perception and experience of alcohol‐related crime and support for strategies to reduce such crime
Tindall, J., Groombridge, D., Wiggers, J. H., Gillham, K. E., Palmer, D., Clinton‐McHarg, T., Lecathelinais, C., & Miller, P. G. (2015) · Drug and Alcohol Review · doi:10.1111/dar.12314 · Cited by 17
A pilot study on the motivational effects of an internet-delivered physical activity behaviour change programme in Nova Scotian cancer survivors
Forbes, C. C., Blanchard, C. M., Mummery, W. K., & Courneya, K. S. (2016) · Psychology and Health · doi:10.1080/08870446.2016.1260725 · Cited by 20
Severe Obesity, Obesity, and Cardiometabolic Risk in Children 0 to 6 Years of Age
Carsley, S., Anderson, L. N., Plumptre, L., Parkin, P. C., Maguire, J. L., Birken, C. S., & Colla, O. B. O. T. T. K. (2017) · Childhood Obesity · doi:10.1089/chi.2017.0004 · Cited by 18
Why Do Males Use Multiple Signals? Insights From Measuring Wild Male Behavior Over Lifespans
Deodhar, S., & Isvaran, K. (2018) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2018.00075 · Cited by 17
Satiety responsiveness but not food reward is modified in response to an acute bout of low versus high intensity exercise in healthy adults
Thivel, D., Fillon, A., Genin, P. M., Miguet, M., Khammassi, M., Pereira, B., Boirie‌, Y., Duclos, M., Drapeau, V., Blundell, J. E., et al. (2019) · Appetite · doi:10.1016/j.appet.2019.104500 · Cited by 17
The Combined Effect of Polygenic Risk from FTO and ADRB2 Gene Variants, Odds of Obesity, and Post-Hipcref Diet Differences
Tan, P. Y., & Mitra, S. R. (2020) · Lifestyle Genomics · doi:10.1159/000505662 · Cited by 17
Lake Superior herring gulls benefit from anthropogenic food subsidies in a prey–impoverished aquatic environment
Serré, S., Irvine, C., Williams, K., & Hebert, C. E. (2022) · Journal of Great Lakes Research · doi:10.1016/j.jglr.2022.08.008 · Cited by 17

Authors: Feise, R. J.
Corresponding author: Feise, Ronald J
ORCID: Feise, Ronald J
Venue: BMC Medical Research Methodology
Publisher: Springer Science and Business Media LLC
Published: 2002-06-17
Volume: 2
Issue: 1
Pages: 8-8
ISSN: 1471-2288 (ISSN-L)
DOI: 10.1186/1471-2288-2-8
PMC: PMC117123
OpenAlex: W2139498473
Cited by: 1,299
References: 42
Citations by year: 2026: 55 · 2025: 67 · 2024: 75 · 2023: 101 · 2022: 79 · 2021: 133 · 2020: 95 · 2019: 115 · 2018: 83 · 2017: 98 · 2016: 72 · 2015: 45 · 2014: 47 · 2013: 33 · 2012: 32
FWCI: 5.75
Type: journal article
Language: en
Open access: gold
doi.org
Licence: www.springer.com/tdm (unspecified)
Locations: BMC Medical Research Methodology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion, other-oa)
PubMed Central (publishedVersion, other-oa)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics: Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Epidemiology
Keywords: p-value adjustment, type I error, multiple comparisons, clinical trials, primary outcomes, statistical significance, sample size
MeSH terms: Clinical Trials as Topic, Data Interpretation, Statistical, Humans, Confidence Intervals, Treatment Outcome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Do multiple outcome measures require p-value adjustment?

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks