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Cited by 143Gastrointestinal motility and disordersGastroesophageal reflux and treatmentsPsychosomatic Disorders and Their Treatments

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

The clinical overlap between functional dyspepsia and irritable bowel syndrome based on Rome III criteria

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WANG, AnJiang, LIAO, XianHua, XIONG, LiShou, PENG, Sui, XIAO, YingLian, LIU, SiChun, HU, PinJin, CHEN, MinHu·2008·BMC Gastroenterology
DOI 10.1186/1471-230x-8-43PMC PMC2569040
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Abstract

Background: Epidemiological studies suggest considerable overlap between functional dyspepsia (FD) and irritable bowel syndrome (IBS). To date, no surveys have been performed to investigate the clinical overlap between these two disorders using Rome III criteria. Our aim was to investigate the prevalence and risk factors for the overlap of FD and IBS based on Rome III criteria in a large clinical sample. Methods: Consecutive patients at the general gastroenterology outpatient clinic were requested to complete a self-report questionnaire. FD and IBS were defined by Rome III criteria. Results: Questionnaires were returned by 3014 patients (52.8% female, 89% response rate). FD-IBS overlap was observed in 5.0% of the patients, while 15.2% and 10.9% of the patients were classified as FD alone and IBS alone, respectively. Compared with non-IBS patients, the odds ratio of having FD among IBS patients was 2.09 (95% CI: 1.68–2.59). Patients with FD-IBS overlap had higher severity scores for the postprandial fullness symptom (2.35 ± 1.49 vs. 1.72 ± 1.59, P < 0.001) and overall FD symptom (6.65 ± 2.88 vs. 5.82 ± 2.76, P = 0.002) than those with FD alone. The only independent risk factor for FD-IBS overlap vs. FD alone was the presence of postprandial fullness symptom (OR 2.67, 95% CI: 1.34–5.31). Conclusion: Clinical overlap of FD and IBS according to Rome III criteria is very common. One risk factor for FD-IBS overlap is the presence of postprandial fullness symptom. This study provides clues for future pathophysiological studies of FD and IBS.

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Figure 1 The prevalence of clinical overlap of functional dyspepsia (FD) and irritable bowel syndrome (IBS) (Total number of patients = 3014).
Figure 1 The prevalence of clinical overlap of functional dyspepsia (FD) and irritable bowel syndrome (IBS) (Total number of patients = 3014).CC BY · PubMed Central

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Research works printed but not linked: 3

  1. Chen MH, Zhong BH, Li CJ, Peng XZ, Hu PJ: An epidemiological study on dyspepsia in Guangdong area. Chin J Intern Med. 1998, 37: 312-314.
  2. Chen MH, Zhong BB, Li CJ: A epidemiological study of dyspepsia in Guangdong area. J Gastroenterol Hepatol. 1997, 12: A199-
  3. Gwee KA, Teng L, Yeoh KG, Ho KY: Patients with functional dyspepsia who have symptoms of irritable bowel syndrome are more likely to have dysmotility-like than ulcer-like dyspepsia. Neurogastroenterol Motil. 2000, 12: 387-

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Metadata

Authors
WANG, A., LIAO, X., XIONG, L., PENG, S., XIAO, Y., LIU, S., HU, P., & CHEN, M.
Affiliations
Sun Yat-sen University (CN)
Corresponding author
CHEN, MinHu
ORCID
Venue
BMC Gastroenterology
Publisher
Springer Science and Business Media LLC
Published
2008-09-23
Volume
8
Issue
1
Pages
43-43
ISSN
1471-230X (ISSN-L)
DOI
10.1186/1471-230x-8-43
PMC
PMC2569040
OpenAlex
W1988429445
Cited by
143
References
28
Citations by year
2025: 5 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 8 · 2020: 8 · 2019: 4 · 2018: 9 · 2017: 16 · 2016: 13 · 2015: 5 · 2014: 11 · 2013: 11 · 2012: 8
FWCI
10.18
Type
journal article
Language
en
Open access
Licence
Locations
  • BMC Gastroenterology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Keywords
functional dyspepsia, irritable bowel syndrome, Rome III criteria, postprandial fullness, symptom severity, risk factors, prevalence, functional gastrointestinal disorders
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, China, Dyspepsia, Factor Analysis, Statistical, Female, Health Surveys, Humans, Male, Middle Aged, Risk Factors, Severity of Illness Index, Prevalence, Multivariate Analysis, Irritable Bowel Syndrome

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