Overlapping upper and lower gastrointestinal symptoms in irritable bowel syndrome patients with constipation or diarrhea
Abstract
Objectives Distinguishing between irritable bowel syndrome (IBS) and functional dyspepsia can be challenging because of the variations in symptom patterns, which commonly overlap. However, the overlap is poorly quantified, and it is equally uncertain whether symptom patterns differ in subgroups of IBS arbitrarily defined by primary bowel patterns of constipation (IBS-C) and diarrhea (IBS-D). We aimed to determine and to compare the distribution of GI symptoms, both, upper and lower, among IBS-C and IBS-D patients. Methods A total of 121 consecutive patients presenting with a diagnosis of IBS were grouped according to primary bowel symptoms as IBS-C (58 women and 18 men, mean age 47 +/- 17 yr) or IBS-D (26 women and 19 men, mean age 47 +/- 15 yr). The Hopkins Bowel Symptom Questionnaire, which includes a brief Quality of Life assessment, and the Hopkins Symptom Checklist 90-Revised were completed by all patients at intake. Results IBS-C patients reported significantly more overall GI symptoms when compared to patients with IBS-D (6.67 vs 4.62, respectively, p Conclusions Upper GI symptoms consistent with functional dyspepsia were more frequent in IBS-C. Although there was considerable overlap of upper and lower GI symptoms in patients with IBS-C and IBS-D, the former had more frequent lower abdominal pain and bloating.
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The overlap between IBS and FD was over 80%.
“The overlap between IBS and FD was over 80%.”
From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [13]
Talley et al. found a significant overlap among IBS, gastroesophageal reflux disease (GERD), and FD.
“In a clinic-based study, Talley et al.13 found a significant overlap among IBS, gastroesophageal reflux disease (GERD), and FD.”
From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [13]
In sub-group analyses patients with constipation-predominant IBS had higher rates of overlap than patients with diarrhea-predominant IBS.
“In sub-group analyses patients with constipation-predominant IBS had higher rates of overlap than patients with diarrhea-predominant IBS.”
From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [13]
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- Authors
- Talley, N. J., Dennis, E. H., Schettler-Duncan, V. A., Lacy, B. E., Olden, K. W., & Crowell, M. D.
- Affiliations
- Mayo Clinic (US)
- Mayo Clinic in Arizona (US)
- Venue
- The American Journal of Gastroenterology
- Published
- 2003-11
- Volume
- 98
- Issue
- 11
- Pages
- 2454-2459
- ISSN
- 0002-9270 (ISSN-L)
- 1572-0241
- OpenAlex
- W2065349462
- Cited by
- 239
- References
- 6
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 9 · 2023: 7 · 2022: 9 · 2021: 3 · 2020: 7 · 2019: 5 · 2018: 5 · 2017: 12 · 2016: 7 · 2015: 13 · 2014: 13 · 2013: 10 · 2012: 15
- FWCI
- 8.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Health Professions › Pharmacy › Infant Health and Development
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- irritable bowel syndrome, irritable bowel syndrome with constipation, diarrhea-predominant irritable bowel syndrome, functional dyspepsia, upper gastrointestinal symptoms, lower gastrointestinal symptoms, abdominal pain, bloating, symptom overlap, somatization, quality of life, personality
- MeSH terms
- Adult, Aged, Constipation, Diarrhea, Dyspepsia, Female, Gastroesophageal Reflux, Humans, Male, Middle Aged, Patient Participation, Prognosis, Surveys and Questionnaires, Severity of Illness Index, Cohort Studies, Comorbidity, Age Distribution, Sex Distribution, Risk Assessment, Irritable Bowel Syndrome
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