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Cited by 228

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Bacteremia causes hippocampal apoptosis in experimental pneumococcal meningitis

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Østergaard, Christian, Leib, Stephen L, Rowland, Ian, Brandt, Christian T·2010·BMC Infectious Diseases
DOI 10.1186/1471-2334-10-1
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Abstract

BACKGROUND: Bacteremia and systemic complications both play important roles in brain pathophysiological alterations and the outcome of pneumococcal meningitis. Their individual contributions to the development of brain damage, however, still remain to be defined. METHODS: Using an adult rat pneumococcal meningitis model, the impact of bacteremia accompanying meningitis on the development of hippocampal injury was studied. The study comprised of the three groups: I. Meningitis (n = 11), II. meningitis with attenuated bacteremia resulting from iv injection of serotype-specific pneumococcal antibodies (n = 14), and III. uninfected controls (n = 6). RESULTS: Pneumococcal meningitis resulted in a significantly higher apoptosis score 0.22 (0.18-0.35) compared to uninfected controls (0.02 (0.00-0.02), Mann Whitney test, P = 0.0003). Also, meningitis with an attenuation of bacteremia by antibody treatment resulted in significantly reduced apoptosis (0.08 (0.02-0.20), P = 0.01) as compared to meningitis. CONCLUSIONS: Our results demonstrate that bacteremia accompanying meningitis plays an important role in the development of hippocampal injury in pneumococcal meningitis.

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Research works printed but not linked: 18

  1. Østergaard C, Konradsen HB, Samuelsson S: Clinical presentation and prognostic factors of Streptococcus pneumoniae meningitis according the focus of infection. BMC Infect Dis. 2005, 5: 1-11. 10.1186/1471-2334-5-93. · DOI
  2. Weisfelt M, Beek van de D, Spanjaard L, Reitsma JB, de Gans J: Clinical features, complications, and outcome in adults with pneumococcal meningitis: a prospective case series. Lancet Neurol. 2006, 5: 123-9. 10.1016/S1474-4422(05)70288-X. · DOI · Paper page
  3. Brandt CT, Frimodt-Møller N, Lundgren JD, Pedersen M, Skovsted IC, Rowland IJ, Østergaard C: Evaluation of anti-pneumococcal capsular antibodies as adjunctive therapy in experimental pneumococcal meningitis. J Antimicrob Chemother. 2006, 58: 1291-4. 10.1093/jac/dkl401. · doi:10.1093/jac/dkl401
  4. Østergaard C, O'Reilly T, Brandt C, Frimodt-Møller N, Lundgren JD: The influence of the blood bacterial load on the meningeal inflammatory response in Streptococcus pneumoniae meningitis. BMC Infect Dis. 2006, 6: 1-7. 10.1186/1471-2334-6-1. · DOI · Paper page
  5. Pedersen M, Brandt CT, Knudsen GM, Østergaard C, Skinhoj P, Skovsted IC, Frimodt-Moller N, Moller K: The effect of S. pneumoniae bacteremia on cerebral blood flow autoregulation in rats. J Cereb Blood Flow Metab. 2008, 28: 126-34. 10.1038/sj.jcbfm.9600514. · DOI
  6. Brandt CT, Holm D, Liptrot M, Østergaard C, Lundgren JD, Frimodt-Moller N, Skovsted IC, Rowland IJ: Impact of Bacteremia on the Pathogenesis of Experimental Pneumococcal Meningitis. J Infect Dis. 2008, 197: 235-44. 10.1086/524874. · DOI
  7. Nau R, Soto A, Bruck W: Apoptosis of neurons in the dentate gyrus in humans suffering from bacterial meningitis. J Neuropathol Exp Neurol. 1999, 58: 265-74. 10.1097/00005072-199903000-00006. · DOI · Paper page
  8. Grandgirard D, Leib SL: Strategies to prevent neuronal damage in paediatric bacterial meningitis. Curr Opin Pediatr. 2006, 18: 112-8. 10.1097/01.mop.0000193292.09894.b7. · DOI
  9. Braun JS, Sublett JE, Freyer D, Mitchell TJ, Cleveland JL, Tuomanen EI, Weber JR: Pneumococcal pneumolysin and H(2)O(2) mediate brain cell apoptosis during meningitis. J Clin Invest. 2002, 109: 19-27. · DOI · Paper page
  10. Leib SL, Clements JM, Lindberg RL, Heimgartner C, Loeffler JM, Pfister LA, Tauber MG, Leppert D: Inhibition of matrix metalloproteinases and tumour necrosis factor alpha converting enzyme as adjuvant therapy in pneumococcal meningitis. Brain. 2001, 124: 1734-42. 10.1093/brain/124.9.1734. · DOI · Paper page
  11. Leib SL, Kim YS, Chow LL, Sheldon RA, Tauber MG: Reactive oxygen intermediates contribute to necrotic and apoptotic neuronal injury in an infant rat model of bacterial meningitis due to group B streptococci. J Clin Invest. 1996, 98: 2632-9. 10.1172/JCI119084. · DOI · Paper page
  12. Orihuela CJ, Fillon S, Smith-Sielicki SH, El Kasmi KC, Gao G, Soulis K, Patil A, Murray PJ, Tuomanen EI: Cell wall-mediated neuronal damage in early sepsis. Infect Immun. 2006, 74: 3783-9. 10.1128/IAI.00022-06. · DOI
  13. Brandt CT, Simonsen H, Liptrot M, Sogaard LV, Lundgren JD, Østergaard C, Frimodt-Moller N, Rowland IJ: In vivo study of experimental pneumococcal meningitis using magnetic resonance imaging. BMC Med Imaging. 2008, 8: 1-10.1186/1471-2342-8-1. · doi:10.1186/1471-2342-8-1
  14. Wellmer A, von Mering M, Spreer A, Diem R, Eiffert H, Noeske C, Bunkowski S, Gold R, Nau R: Experimental pneumococcal meningitis: Impaired clearance of bacteria from the blood due to increased apoptosis in the spleen in Bcl-2-deficient mice. Infect Immun. 2004, 72: 3113-9. 10.1128/IAI.72.6.3113-3119.2004. · DOI
  15. de Jonge RC, Swart JF, Koomen I, Rombouts SA, Gemke RJ, Barkhof F, van Furth AM: No structural cerebral differences between children with a history of bacterial meningitis and healthy siblings. Acta Paediatr. 2008, 97: 1390-6. · DOI
  16. Loeffler JM, Ringer R, Hablutzel M, Tauber MG, Leib SL: The free radical scavenger alpha-phenyl-tert-butyl nitrone aggravates hippocampal apoptosis and learning deficits in experimental pneumococcal meningitis. J Infect Dis. 2001, 183: 247-52. 10.1086/317921. · DOI
  17. Pfister LA, Tureen JH, Shaw S, Christen S, Ferriero DM, Tauber MG, Leib SL: Endothelin inhibition improves cerebral blood flow and is neuroprotective in pneumococcal meningitis. Ann Neurol. 2000, 47: 329-35. 10.1002/1531-8249(200003)47:3<329::AID-ANA8>3.0.CO;2-R. · doi:10.1002/1531-8249(200003)47:3<329::aid-ana8>3.0.co;2-r
  18. Gianinazzi C, Grandgirard D, Imboden H, Egger L, Meli DN, Bifrare YD, Joss PC, Tauber MG, Borner C, Leib SL: Caspase-3 mediates hippocampal apoptosis in pneumococcal meningitis. Acta Neuropathol (Berl). 2003, 105: 499-507. · DOI

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Metadata

Authors
Østergaard, C., Leib, S. L., Rowland, I., & Brandt, C. T.
Venue
BMC Infectious Diseases
Publisher
Springer Science and Business Media LLC
Published
2010-01-03
Volume
10
Issue
1
Pages
1-1
ISSN
1471-2334 (ISSN-L)
DOI
10.1186/1471-2334-10-1
OpenAlex
W2065913295
Cited by
228
References
1
FWCI
11.92
Type
journal article
Language
en
Open access
gold
Licence
creativecommons.org/licenses/by/2.0 (tdm)

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CoChat. (2026). Citation check: Bacteremia causes hippocampal apoptosis in experimental pneumococcal meningitis. https://app.cochat.ai/papers/10.1186/1471-2334-10-1
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Østergaard, C., Leib, S. L., Rowland, I., & Brandt, C. T. (2010). Bacteremia causes hippocampal apoptosis in experimental pneumococcal meningitis. BMC Infectious Diseases. https://doi.org/10.1186/1471-2334-10-1

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