The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Pneumococcal pneumolysin and H2O2 mediate brain cell apoptosis during meningitis
Open accessAbstract
Pneumococcus is the most common and aggressive cause of bacterial meningitis and induces a novel apoptosis-inducing factor-dependent (AIF-dependent) form of brain cell apoptosis. Loss of production of two pneumococcal toxins, pneumolysin and H(2)O(2), eliminated mitochondrial damage and apoptosis. Purified pneumolysin or H(2)O(2) induced microglial and neuronal apoptosis in vitro. Both toxins induced increases of intracellular Ca(2+) and triggered the release of AIF from mitochondria. Chelating Ca(2+) effectively blocked AIF release and cell death. In experimental pneumococcal meningitis, pneumolysin colocalized with apoptotic neurons of the hippocampus, and infection with pneumococci unable to produce pneumolysin and H(2)O(2) significantly reduced damage. Two bacterial toxins, pneumolysin and, to a lesser extent, H(2)O(2), induce apoptosis by translocation of AIF, suggesting new neuroprotective strategies for pneumococcal meningitis.
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Cites
Molecular characterization of mitochondrial apoptosis-inducing factor
Susin, S. A., Lorenzo, H. K., Zamzami, N., Marzo, I., Snow, B. E., Brothers, G. M., Mangion, J., Jacotot, E., Costantini, P., Loeffler, M., et al. (1999) · Nature · doi:10.1038/17135 · Cited by 4,060
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van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880
The mitochondrial permeability transition pore and its role in cell death
CROMPTON, M. (1999) · Biochemical Journal · doi:10.1042/bj3410233 · Cited by 2,432
Acute Bacterial Meningitis in Adults -- A Review of 493 Episodes
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Cited by
The Semantics of Microglia Activation: Neuroinflammation, Homeostasis, and Stress
Woodburn, S. C., Bollinger, J. L., & Wohleb, E. S. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02309-6 · Cited by 783
Role of Microglia in Central Nervous System Infections
Rock, R. B., Gekker, G., Hu, S., Sheng, W. S., Cheeran, M., Lokensgard, J. R., & Peterson, P. K. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.4.942-964.2004 · Cited by 723
Role of AIF in caspase-dependent and caspase-independent cell death
Cregan, S. P., Dawson, V. L., & Slack, R. S. (2004) · Oncogene · doi:10.1038/sj.onc.1207517 · Cited by 517
Pathogenesis and Pathophysiology of Pneumococcal Meningitis
Mook-Kanamori, B. B., Geldhoff, M., van der Poll, T., & van de Beek, D. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00008-11 · Cited by 492
Calpain I Induces Cleavage and Release of Apoptosis-inducing Factor from Isolated Mitochondria
Polster, B. M., Basañez, G., Etxebarria, A., Hardwick, J. M., & Nicholls, D. G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413269200 · Cited by 437
Metadata
- Authors
- Braun, J. S., Sublett, J. E., Freyer, D., Mitchell, T. J., Cleveland, J. L., Tuomanen, E. I., & Weber, J. R.
- Venue
- Journal of Clinical Investigation
- Published
- 2002-01-01
- Volume
- 109
- Issue
- 1
- Pages
- 19-27
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1984369710
- Cited by
- 313
- References
- 6
- FWCI
- 17.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Braun, J. S., Sublett, J. E., Freyer, D., Mitchell, T. J., Cleveland, J. L., Tuomanen, E. I., & Weber, J. R. (2002). Pneumococcal pneumolysin and H2O2 mediate brain cell apoptosis during meningitis. Journal of Clinical Investigation. https://doi.org/10.1172/jci12035
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
