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The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Prophylactic cranial irradiation in small cell lung cancer: a systematic review of the literature with meta-analysis

Open access
Meert, Anne-Pascale, Paesmans, Marianne, Berghmans, Thierry, Martin, Benoît, Mascaux, Céline, Vallot, Frédéric, Verdebout, Jean-Marc, Lafitte, Jean-Jacques, Sculier, Jean-Paul·2001·BMC Cancer
DOI 10.1186/1471-2407-1-5
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Abstract

Abstract Purpose A systematic review of the literature was carried out to determine the role of prophylactic cranial irradiation (PCI) in small cell lung cancer (SCLC) . Methods To be eligible, full published trials needed to deal with SCLC and to have randomly assigned patients to receive PCI or not. Trials quality was assessed by two scores (Chalmers and ELCWP). Results Twelve randomised trials (1547 patients) were found to be eligible. Five evaluated the role of PCI in SCLC patients who had complete response (CR) after chemotherapy. Brain CT scan was done in the work-up in five studies and brain scintigraphy in six. Chalmers and ELCWP scores are well correlated (p < 0.001), with respective median scores of 32.6 and 38.8 %. This meta-analysis based on the available published data reveals a decrease of brain metastases incidence (hazard ratio (HR): 0.48; 95 % confidence interval (CI): 0.39 - 0.60) for all the studies and an improvement of survival (HR: 0.82; 95 % CI: 0.71 - 0.96) in patients in CR in favour of the PCI arm. Unfortunately, long-term neurotoxicity was not adequately described . Conclusions PCI decreases brain metastases incidence and improves survival in CR SCLC patients but these effects were obtained in patients who had no systematic neuropsychological and brain imagery assessments. The long-term toxicity has not been prospectively evaluated. If PCI can be recommended in patients with SCLC and CR documented by a work-up including brain CT scan, data are lacking to generalise its use to any CR situations.

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Metadata

Authors
Meert, A.-P., Paesmans, M., Berghmans, T., Martin, B., Mascaux, C., Vallot, F., Verdebout, J.-M., Lafitte, J.-J., & Sculier, J.-P.
Venue
BMC Cancer
Publisher
Springer Science and Business Media LLC
Published
2001-06-19
Volume
1
Issue
1
ISSN
1471-2407
DOI
10.1186/1471-2407-1-5
OpenAlex
W2134855461
Cited by
281
References
4
FWCI
1.83
Type
journal article
Language
en
Open access
green
Licence

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CoChat. (2026). Citation check: Prophylactic cranial irradiation in small cell lung cancer: a systematic review of the literature with meta-analysis. https://app.cochat.ai/papers/10.1186/1471-2407-1-5
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Meert, A.-P., Paesmans, M., Berghmans, T., Martin, B., Mascaux, C., Vallot, F., Verdebout, J.-M., Lafitte, J.-J., & Sculier, J.-P. (2001). Prophylactic cranial irradiation in small cell lung cancer: a systematic review of the literature with meta-analysis. BMC Cancer. https://doi.org/10.1186/1471-2407-1-5

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