Cited by 380

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: a representative population prospective cohort study of 800,000 individuals

Lee, Meei-Shyuan, Hsu, Chih-Cheng, Wahlqvist, Mark L, Tsai, Hsin-Ni, Chang, Yu-Hung, Huang, Yi-Chen·2011·BMC Cancer

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1186/1471-2407-11-20

Cites

6 of 6 references verified0 citation errors · 0 not checkable

Statistics

Figures

Figure 1 Hazard ratios in metformin-treated type 2 diabetes for cancer incidence for men (n = 8,167). Adjusted for age group, gender, other oral anti-hyperglycemic medication, CCI score, and duration of metformin exposure (a time dependent variable). Reference: Diabetes patients use oral anti-hyperglycemic medication except metformin.
Figure 1 Hazard ratios in metformin-treated type 2 diabetes for cancer incidence for men (n = 8,167). Adjusted for age group, gender, other oral anti-hyperglycemic medication, CCI score, and duration of metformin exposure (a time dependent variable). Reference: Diabetes patients use oral anti-hyperglycemic medication except metformin.CC BY · PubMed Central
Figure 2 Hazard ratios in metformin-treated type 2 diabetes for cancer incidence for women (n = 7,100). Adjusted for age group, gender, other oral anti-hyperglycemic medication, CCI score, and duration of metformin exposure (a time dependent variable). Reference: Diabetes patients use oral anti-hyperglycemic medication except metformin.
Figure 2 Hazard ratios in metformin-treated type 2 diabetes for cancer incidence for women (n = 7,100). Adjusted for age group, gender, other oral anti-hyperglycemic medication, CCI score, and duration of metformin exposure (a time dependent variable). Reference: Diabetes patients use oral anti-hyperglycemic medication except metformin.CC BY · PubMed Central

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Research works printed but not linked: 35

  1. Coughlin SS, Calle EE, Teras LR, Petrelli J, Thun MJ: Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults. Am J Epidemiol. 2004, 159 (12): 1160-1167. 10.1093/aje/kwh161. · DOI
  2. Levine W, Dyer AR, Shekelle RB, Schoenberger JA, Stamler J: Post-load plasma glucose and cancer mortality in middle-aged men and women. 12-year follow-up findings of the Chicago Heart Association Detection Project in Industry. Am J Epidemiol. 1990, 131 (2): 254-262. · DOI
  3. Saydah SH, Loria CM, Eberhardt MS, Brancati FL: Abnormal glucose tolerance and the risk of cancer death in the United States. Am J Epidemiol. 2003, 157 (12): 1092-1100. 10.1093/aje/kwg100. · DOI
  4. Weiderpass E, Gridley G, Nyren O, Ekbom A, Persson I, Adami HO: Diabetes mellitus and risk of large bowel cancer. J Natl Cancer Inst. 1997, 89 (9): 660-661. 10.1093/jnci/89.9.660. · DOI
  5. Will JC, Galuska DA, Vinicor F, Calle EE: Colorectal cancer: another complication of diabetes mellitus?. Am J Epidemiol. 1998, 147 (9): 816-825. · DOI
  6. Everhart J, Wright D: Diabetes mellitus as a risk factor for pancreatic cancer. A meta-analysis. JAMA. 1995, 273 (20): 1605-1609. 10.1001/jama.273.20.1605. · DOI
  7. Li D, Yeung SC, Hassan MM, Konopleva M, Abbruzzese JL: Antidiabetic therapies affect risk of pancreatic cancer. Gastroenterology. 2009, 137 (2): 482-488. 10.1053/j.gastro.2009.04.013. · DOI · Paper page
  8. Yang YX: Do diabetes drugs modify the risk of pancreatic cancer?. Gastroenterology. 2009, 137 (2): 412-415. 10.1053/j.gastro.2009.06.022. · DOI
  9. Yang YX, Hennessy S, Lewis JD: Insulin therapy and colorectal cancer risk among type 2 diabetes mellitus patients. Gastroenterology. 2004, 127 (4): 1044-1050. 10.1053/j.gastro.2004.07.011. · DOI
  10. Chong CR, Chabner BA: Mysterious metformin. Oncologist. 2009, 14 (12): 1178-1181. 10.1634/theoncologist.2009-0286. · DOI
  11. Duncan BB, Schmidt MI: Metformin, cancer, alphabet soup, and the role of epidemiology in etiologic research. Diabetes Care. 2009, 32 (9): 1748-1750. 10.2337/dc09-1183. · DOI
  12. Jiralerspong S, Giordano SH, Meric-Bernstam F, Barnett CM, Kau S, Hung MC, Hortobagyi GN, Gonzalez-Angulo AM: The effects of metformin on pathologic complete response (pCR) rates in diabetic breast cancer (BC) patients receiving neoadjuvant systemic therapy (NST). American Society of Clinical Oncology. 2008, 26: 508- · DOI
  13. Oliveria SA, Koro CE, Yood MU, Sowell M: Cancer incidence among patients treated with antidiabetic pharmacotherapy. Cancer incidence among patients treated with antidiabetic pharmacotherapy. 2008, 2 (1): 47-57.
  14. Evans JM, Donnelly LA, Emslie-Smith AM, Alessi DR, Morris AD: Metformin and reduced risk of cancer in diabetic patients. BMJ. 2005, 330 (7503): 1304-1305. 10.1136/bmj.38415.708634.F7. · DOI · Paper page
  15. Libby G, Donnelly LA, Donnan PT, Alessi DR, Morris AD, Evans JM: New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes. Diabetes Care. 2009, 32 (9): 1620-1625. 10.2337/dc08-2175. · DOI · Paper page
  16. Currie CJ, Poole CD, Gale EA: The influence of glucose-lowering therapies on cancer risk in type 2 diabetes. Diabetologia. 2009, 52 (9): 1766-1777. 10.1007/s00125-009-1440-6. · DOI · Paper page
  17. Donadon V, Balbi M, Ghersetti M, Grazioli S, Perciaccante A, Della Valentina G, Gardenal R, Dal Mas M, Casarin P, Zanette G, et al: Antidiabetic therapy and increased risk of hepatocellular carcinoma in chronic liver disease. World J Gastroenterol. 2009, 15 (20): 2506-2511. 10.3748/wjg.15.2506. · DOI
  18. Park S, Bae J, Nam BH, Yoo KY: Aetiology of cancer in Asia. Asian Pac J Cancer Prev. 2008, 9 (3): 371-380.
  19. World Cancer Research Fund/American Institute for Cancer Research: Policy and Action for Cancer Prevention. Food, Nutrition, and Physical Activity: a Global Perspective. 2009, Washington DC: AICR
  20. World Cancer Research Fund/American Institute for Cancer Research: Food, Nutrition, Physical Activity, and the Prevention of Cancer: a Global Perspective. 2007, Washington DC: AICR
  21. Suissa S: Immortal Time Bias in Pharmacoepidemiology. Am J Epidemio. 2008, 167: 492-499. 10.1093/aje/kwm324. · DOI
  22. Charlson ME, Pompei P, Ales KL, MacKenzie CR: A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987, 40: 373-383. 10.1016/0021-9681(87)90171-8. · DOI · Paper page
  23. Chen CJ, You SL, Lin LH, Hsu WL, Yang YW: Cancer epidemiology and control in Taiwan: a brief review. Jpn J Clin Oncol. 2002, 32 (Suppl): S66-81. 10.1093/jjco/hye138. · DOI
  24. Chitturi S, Farrell GC, Hashimoto E, Saibara T, Lau GK, Sollano JD: Non-alcoholic fatty liver disease in the Asia-Pacific region: definitions and overview of proposed guidelines. J Gastroenterol Hepatol. 2007, 22 (6): 778-787. 10.1111/j.1440-1746.2007.05001.x. · DOI
  25. Black SA: Diabetes, diversity, and disparity: what do we do with the evidence?. Am J Public Health. 2002, 92 (4): 543-548. 10.2105/AJPH.92.4.543. · DOI
  26. Gabal LL, Goodman-Gruen D, Barrett-Connor E: The effect of postmenopausal estrogen therapy on the risk of non-insulin-dependent diabetes mellitus. Am J Public Health. 1997, 87 (3): 443-445. 10.2105/AJPH.87.3.443. · DOI
  27. Guercio G, Di Palma MI, Pepe C, Saraco NI, Prieto M, Saure C, Mazza C, Rivarola MA, Belgorosky A: Metformin, Estrogen Replacement Therapy and Gonadotropin Inhibition Fail to Improve Insulin Sensitivity in a Girl with Aromatase Deficiency. Horm Res. 2009, 72 (6): 370-376. 10.1159/000249165. · DOI
  28. de Kok IM, Wong CS, Chia KS, Sim X, Tan CS, Kiemeney LA, Verkooijen HM: Gender differences in the trend of colorectal cancer incidence in Singapore, 1968-2002. Int J Colorectal Dis. 2008, 23 (5): 461-467. 10.1007/s00384-007-0421-9. · DOI
  29. Nguyen SP, Bent S, Chen YH, Terdiman JP: Gender as a risk factor for advanced neoplasia and colorectal cancer: a systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2009, 7 (6): 676-681. 10.1016/j.cgh.2009.01.008. e671-673. · DOI
  30. Gao RN, Neutel CI, Wai E: Gender differences in colorectal cancer incidence, mortality, hospitalizations and surgical procedures in Canada. J Public Health (Oxf). 2008, 30 (2): 194-201. 10.1093/pubmed/fdn019. · DOI
  31. Naugler WE, Sakurai T, Kim S, Maeda S, Kim K, Elsharkawy AM, Karin M: Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science. 2007, 317 (5834): 121-124. 10.1126/science.1140485. · DOI · Paper page
  32. Villa E, Ferretti I, Grottola A, Buttafoco P, Buono MG, Giannini F, Manno M, Bertani H, Dugani A, Manenti F: Hormonal therapy with megestrol in inoperable hepatocellular carcinoma characterized by variant oestrogen receptors. Br J Cancer. 2001, 84 (7): 881-885. 10.1054/bjoc.2000.1534. · DOI
  33. Morin-Papunen L, Rautio K, Ruokonen A, Hedberg P, Puukka M, Tapanainen JS: Metformin reduces serum C-reactive protein levels in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2003, 88 (10): 4649-4654. 10.1210/jc.2002-021688. · DOI
  34. Gordon GG, Olivo J, Rafil F, Southren AL: Conversion of androgens to estrogens in cirrhosis of the liver. J Clin Endocrinol Metab. 1975, 40 (6): 1018-1026. 10.1210/jcem-40-6-1018. · DOI · Paper page
  35. Salpeter S, Greyber E, Pasternak G, Salpeter E: Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. Cochrane Database Syst Rev. 2006, CD002967-1 · DOI · Paper page

Cited by

Sorted by citations

See all 380

Metadata

Authors
Lee, M.-S., Hsu, C.-C., Wahlqvist, M. L., Tsai, H.-N., Chang, Y.-H., & Huang, Y.-C.
Venue
BMC Cancer
Published
2011-01-18
Volume
11
Issue
1
ISSN
1471-2407
Cited by
380
References
6
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review