The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Molecular characterization of exosome-like vesicles from breast cancer cells
Open accessAbstract
BACKGROUND: Membrane vesicles released by neoplastic cells into extracellular medium contain potential of carrying arrays of oncogenic molecules including proteins and microRNAs (miRNA). Extracellular (exosome-like) vesicles play a major role in cell-to-cell communication. Thus, the characterization of proteins and miRNAs of exosome-like vesicles is imperative in clarifying intercellular signaling as well as identifying disease markers. METHODS: Exosome-like vesicles were isolated using gradient centrifugation from MCF-7 and MDA-MB 231 cultures. Proteomic profiling of vesicles using liquid chromatography-mass spectrometry (LC-MS/MS) revealed different protein profiles of exosome-like vesicles derived from MCF-7 cells (MCF-Exo) than those from MDA-MB 231 cells (MDA-Exo). RESULTS: The protein database search has identified 88 proteins in MDA-Exo and 59 proteins from MCF-Exo. Analysis showed that among all, 27 proteins were common between the two exosome-like vesicle types. Additionally, MDA-Exo contains a higher amount of matrix-metalloproteinases, which might be linked to the enhanced metastatic property of MDA-MB 231 cells. In addition, microarray analysis identified several oncogenic miRNA between the two types vesicles. CONCLUSIONS: Identification of the oncogenic factors in exosome-like vesicles is important since such vesicles could convey signals to non-malignant cells and could have an implication in tumor progression and metastasis.
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TM4: a free, open-source system for microarray data management and analysis
Saeed, A. I., Sharov, V., White, J., Li, J., Liang, W., Bhagabati, N., Braisted, J., Klapa, M., Currier, T., Thiagarajan, M., et al. (2003) · BioTechniques · doi:10.2144/03342mt01 · Cited by 4,837
Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
Chiang, H. R., Schoenfeld, L. W., Ruby, J. G., Auyeung, V. C., Spies, N., Baek, D., Johnston, W. K., Russ, C., Luo, S., Babiarz, J. E., et al. (2010) · Genes & Development · doi:10.1101/gad.1884710 · Cited by 825
Cited by
Syn, N., Wang, L., Sethi, G., Thiery, J.-P., & Goh, B.-C. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.04.006 · Cited by 478
Hannafon, B. N., Carpenter, K. J., Berry, W. L., Janknecht, R., Dooley, W. C., & Ding, W.-Q. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0400-7 · Cited by 218
Cancer Extracellular Vesicles: Next-Generation Diagnostic and Drug Delivery Nanotools
Palazzolo, S., Memeo, L., Hadla, M., Duzagac, F., Steffan, A., Perin, T., Canzonieri, V., Tuccinardi, T., Caligiuri, I., & Rizzolio, F. (2020) · Cancers · doi:10.3390/cancers12113165 · Cited by 34
Minic, Z., Li, Y., Hüttmann, N., Uppal, G. K., D’Mello, R., & Berezovski, M. V. (2023) · Biomedicines · doi:10.3390/biomedicines11041076 · Cited by 20
Metadata
- Authors
- Kruger, S., Elmageed, Z. Y. A., Hawke, D. H., Wörner, P. M., Jansen, D. A., Abdel-Mageed, A. B., Alt, E. U., & Izadpanah, R.
- Venue
- BMC Cancer
- Published
- 2014-01-27
- Volume
- 14
- Issue
- 1
- Pages
- 44-44
- ISSN
- 1471-2407 (ISSN-L)
- OpenAlex
- W1991087195
- Cited by
- 160
- References
- 2
- FWCI
- 7.18
- Type
- journal article
- Language
- en
- Open access
- gold
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- Kruger, S., Elmageed, Z. Y. A., Hawke, D. H., Wörner, P. M., Jansen, D. A., Abdel-Mageed, A. B., Alt, E. U., & Izadpanah, R. (2014). Molecular characterization of exosome-like vesicles from breast cancer cells. BMC Cancer. https://doi.org/10.1186/1471-2407-14-44
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