Fine-needle aspiration for diagnosis of tuberculous lymphadenitis in children in Bangui, Central African Republic
Open accessAbstract
BACKGROUND: Tuberculosis (TB) is a major cause of childhood morbidity and mortality in developing countries. One of the main difficulties is obtaining adequate specimens for bacteriological confirmation of the disease in children.The aim of this study is to evaluate the adequacy of fine-needle aspiration (FNA) for the diagnosis of TB. METHODS: In a prospective study conducted at the paediatric hospital in Bangui in 2007-2009, we used fine-needle aspiration to obtain samples for diagnosis of TB from 131 children aged 0-17 years with persistent lymphadenitis. RESULTS: Fine-needle aspiration provided samples that could be used for bacteriological confirmation of TB. Ziehl-Neelsen staining for acid-fast bacilli was positive in 42.7% of samples, and culture identified TB in 67.2% of cases. Of 75 samples that were stain-negative, 49 (65.3%) were culture-positive, while 12 stain-positive samples remained culture-negative. Ten of the 12 stain-positive, culture-negative samples were from patients who had received previous antimicrobial therapy. With regard to phenotypic drug susceptibility, 81/88 strains (91.1%) were fully susceptible to isoniazid, rifampicin, ethambutol and streptomycin, six (6.8%) were resistant to one drug, and one multidrug-resistant strain was found. CONCLUSIONS: Fine-needle aspiration is simple, cost-effective and non-invasive and can be performed by trained staff. Combined with rapid molecular diagnostic tests, fine-needle aspirates could improve the diagnosis of TB and provide valuable information for appropriate treatment and drug resistance.
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Extrapulmonary tuberculosis, including TL, is more common in immunocompromised patients, such as those with HIV infection; in these patients, the disease is almost always secondary to reactivation of a latent tuberculosis infection.
“Extrapulmonary tuberculosis, including TL, is more common in immunocompromised patients, such as those with HIV infection; in these patients, the disease is almost always secondary to reactivation of a latent tuberculosis infection.12”
From Epidemiology and Diagnosis of Tuberculous Lymphadenitis in a Tuberculosis Low-Burden Country (2015) · cites this paper as [12]
The Background (page unavailable) says extrapulmonary TB is common in children with TB, reports HIV co-infection among children treated for TB in Bangui, and describes lymphadenitis as common among extrapulmonary cases. It does not establish that extrapulmonary TB is more common in immunocompromised patients than in others. Neither the Background nor the other retrieved passages address the claim that disease in these patients is almost always due to reactivation of latent infection. (LLM, conf=0.84)
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Cites
Rapid Molecular Detection of Tuberculosis and Rifampin Resistance
Boehme, C. C., Nabeta, P., Hillemann, D., Nicol, M. P., Shenai, S., Krapp, F., Allen, J., Tahirli, R., Blakemore, R., Rustomjee, R., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0907847 · Cited by 2,309 · see citing works
Xpert MTB/RIF: a New Pillar in Diagnosis of Extrapulmonary Tuberculosis?
Vadwai, V., Boehme, C., Nabeta, P., Shetty, A., Alland, D., & Rodrigues, C. (2011) · Journal of Clinical Microbiology · doi:10.1128/jcm.02319-10 · Cited by 357 · see citing works
Chintu, C., Mudenda, V. C., Lucas, S. B., Nunn, A., Lishimpi, K., Maswahu, D., Kasolo, F. C., Mwaba, P., Bhat, G., Terunuma, H., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11082-8 · Cited by 332 · see citing works
Diagnosis and treatment of tuberculosis in children
Shingadia, D. V., & Novelli, V. (2003) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(03)00771-0 · Cited by 302 · see citing works
Clinical manifestations of tuberculosis in children
Cruz, A. T., & Starke, J. R. (2007) · Paediatric Respiratory Reviews · doi:10.1016/j.prrv.2007.04.008 · Cited by 204 · see citing works
The burden of childhood tuberculosis and the accuracy of community-based surveillance data.
Marais, B. J., Hesseling, A. C., Gie, R. P., Schaaf, H. S., & Beyers, N. (2006) · PubMed · Cited by 180 · see citing works
Canetti, G., Rist, N., & Grosset, J. H. E. (1998) · PubMed · Cited by 138 · see citing works
Ligthelm, L. J., Nicol, M. P., Hoek, K. G. P., Jacobson, R., van Helden, P. D., Marais, B. J., Warren, R. M., & Wright, C. A. (2011) · Journal of Clinical Microbiology · doi:10.1128/jcm.01310-11 · Cited by 123 · cited 2× · see citing works
“management of mycobacterial infection in children [19,20].”
Tuberculosis in women and children
Marais, B. J., Gupta, A., Starke, J. R., & Sony, A. E. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60579-x · Cited by 70 · see citing works
(2009) · PubMed · Cited by 59 · see citing works
Sreeramareddy, C. T., Ramakrishnareddy, N., Shah, R. K., Baniya, R., & Swain, P. K. (2010) · BMC Pediatrics · doi:10.1186/1471-2431-10-57 · Cited by 31 · see citing works
Diagnosis of tuberculous lymphadenitis using fine needle aspiration biopsy
Knox, J., Lane, G., Wong, J. S. J., Trevan, P. G., & Karunajeewa, H. (2012) · Internal Medicine Journal · doi:10.1111/j.1445-5994.2012.02748.x · Cited by 31 · see citing works
Surveillance of drug-resistant childhood tuberculosis in Bangui, Central African Republic.
Kassa-Kelembho, E., Bobossi-Serengbé, G., Ec, T., Tb, N.-K., Yapou, F., & Talarmin, A. (2004) · PubMed · Cited by 26 · see citing works
Minime-Lingoupou, F., Manirakiza, A., Yango, F., Zandanga, G., Faou, A. L., & Rigouts, L. (2011) · The International Journal of Tuberculosis and Lung Disease · doi:10.5588/ijtld.10.0292 · Cited by 15 · see citing works
Self-citationJl, K., Jj, B., Gérôme, P., Fabre, M., Houmed, A., Hervé, & Teyssou, R. (2002) · PubMed · Cited by 15 · see citing works
(2011) · PubMed · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Diagnosis and treatment of paediatric tuberculosis: An insight review
Mandal, N., Anand, P. K., Gautam, S., Das, S., & Hussain, T. (2017) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2016.1262813 · Cited by 84 · see citing works
Les tuberculoses extrapulmonaires
Ketata, W., Rekik, W. K., Ayadi, H., & Kammoun, S. (2014) · Revue de Pneumologie Clinique · doi:10.1016/j.pneumo.2014.04.001 · Cited by 73 · see citing works
New Diagnostics for Childhood Tuberculosis
Chiang, S. S., Swanson, D. S., & Starke, J. R. (2015) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2015.05.011 · Cited by 60 · see citing works
Epidemiology and Diagnosis of Tuberculous Lymphadenitis in a Tuberculosis Low-Burden Country
Salvador, F., Los-Arcos, I., Sánchez-Montalvá, A., Tórtola, T., Curran, A., Villar, A., Saborit, N., Castellví, J., & Molina, I. (2015) · Medicine · doi:10.1097/md.0000000000000509 · Cited by 43 · see citing works
Fantahun, M., Kebede, A., Yenew, B., Gemechu, T., Mamuye, Y., Tadesse, M., Brhane, B., Jibriel, A., Solomon, D., & Yaregal, Z. (2019) · PLoS ONE · doi:10.1371/journal.pone.0222402 · Cited by 38 · see citing works
Combination method for the diagnosis of Tuberculous lymphadenitis in high burden settings
Shetty, D., & Vyas, D. (2022) · Surgical and Experimental Pathology · doi:10.1186/s42047-022-00111-z · Cited by 25 · see citing works
Cervical tuberculous lymphadenitis: diagnosis and demographics, a five-year case series in the UK
Moualed, D., Robinson, M., Qureishi, A., & Gurr, P. (2018) · Annals of The Royal College of Surgeons of England · doi:10.1308/rcsann.2018.0021 · Cited by 17 · see citing works
A case-report of a pulmonary tuberculosis with lymphadenopathy mimicking a lymphoma
Collu, C., Fois, A. G., Crivelli, P., Tidore, G., Fozza, C., Sotgiu, G., & Pirina, P. (2018) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2018.02.011 · Cited by 15 · see citing works
Chiang, S. S., & Starke, J. R. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-40181-4.00134-1 · Cited by 13 · see citing works
Ho, U., Chen, C., Lin, C.-Y., Hsu, Y.-C., Chi, F.-H., Chou, C., Chen, T., Wang, C., Lou, P., Ko, J., et al. (2016) · European Radiology · doi:10.1007/s00330-015-4159-4 · Cited by 12 · see citing works
Rao, H. B., Nair, P., Priya, S., Vallonthaiel, A. G., Sathyapalan, D. T., Koshy, A. K., & Venu, R. P. (2021) · World Journal of Gastrointestinal Endoscopy · doi:10.4253/wjge.v13.i12.649 · Cited by 10 · see citing works
Smith, J. P., Song, R., McCarthy, K. D., Mchembere, W., Click, E. S., & Cain, K. P. (2022) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofac560 · Cited by 6 · see citing works
Chiang, S. S., & Starke, J. R. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-75608-2.00134-8 · Cited by 4 · see citing works
Concomitant Madura Foot and Tuberculosis in a Child: A Diagnostic Dilemma!
Sharma, S., & Sharma, S. C. (2014) · Journal of Foot and Ankle Surgery (Asia Pacific) · doi:10.5005/jp-journals-10040-1016 · Cited by 3 · see citing works
Heij, H. A. (2021) · Springer eBooks · doi:10.1007/978-3-662-43559-5_92 · Cited by 2 · see citing works
The Diagnostic Value of Sonographic Findings in Axillary Lymphadenopathy
Çolak, E. (2015) · Journal of Family Medicine and Health Care · doi:10.11648/j.jfmhc.20150102.11 · Cited by 1 · see citing works
AlQudehy, Z., & Al-Khars, Z. (2014) · The Egyptian Journal of Otolaryngology · doi:10.4103/1012-5574.133216 · Cited by 1 · see citing works
Heij, H. A. (2020) · Springer eBooks · doi:10.1007/978-3-642-38482-0_92-1
Pediatric Extrapulmonary Tuberculosis, One Center Six Years Experience
Gülhan, B., & Yüksek, S. K. (2020) · Journal of Dr Behcet Uz Children s Hospital · doi:10.5222/buchd.2020.32704
Role of FNAC in Chronic Childhood Lymphadenopathy with Suspected Tuberculosis
Sumathi, S., & Padma, K. (2019) · International Journal of Contemporary Medical Research [IJCMR] · doi:10.21276/ijcmr.2019.6.6.24
Musoni, E., Niyodusenga, A., Iradukunda, S., & Uwamahoro, C. (2020) · Rwanda Journal of Medicine and Health Sciences · doi:10.4314/rjmhs.v3i1.10
Cervical lymphadenopathy of Togolese children in a tropical context: clinicopathological study
Darré, T., Doukouré, B., Djiwa, T., Amana, B., Bissa, H., & Napo‐Koura, G. (2020) · Tropical Doctor · doi:10.1177/0049475520947882
Cytomorphological study of lymph node lesions
Majithia, H. J., Algotar, C. G., Chokshi, T., Mori, N. K., & Ghelani, S. (2020) · IP Archives of Cytology and Histopathology Research · doi:10.18231/j.achr.2020.061
Cytomorphological Pattern of Lymph Node Swelling in Tertiary Care Unit
Shahzad, H., Rahat, N., Anwer, M., Kashif, H., Gul, S., & Momin, Z. (2022) · Pakistan Journal of Medical and Health Sciences · doi:10.53350/pjmhs22165224
Linfadenitis tuberculosa en niños: Revisión sistemática de reportes de caso
García-Rodríguez, T., Guarniz-Huamán, D. A., García-Gutiérrez, F. M., Ramírez, S. F. G., Pérez, K. L. G., Floriano, L. A. G., Armas, E. J. G., Rojas, A. A. G., & Huayta, M. N. M. (2022) · Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo · doi:10.35434/rcmhnaaa.2022.153.1550
- Authors
- Fanny, M.-L., Beyam, N., Gody, J. C., Zandanga, G., Yango, F., Manirakiza, A., Rigouts, L., Pierre-Audigier, C., Gicquel, B., & Bobossi, G.
- Affiliations
- Institut Pasteur de Bangui (CF)
- University of Antwerp (BE)
- Institut Pasteur (FR)
- Venue
- BMC Pediatrics
- Published
- 2012-12
- Volume
- 12
- Issue
- 1
- Pages
- 191-191
- ISSN
- 1471-2431 (ISSN-L)
- PMC
- PMC3538580
- OpenAlex
- W2034582455
- Cited by
- 25
- References
- 16
- Citations by year
- 2022: 5 · 2021: 2 · 2020: 5 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 3
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Pediatrics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Surgery › Diagnosis and treatment of tuberculosis
- Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
- Keywords
- tuberculous lymphadenitis, fine-needle aspiration, pediatric tuberculosis, bacteriological confirmation, acid-fast staining, Ziehl-Neelsen staining, Mycobacterium tuberculosis culture, multidrug resistance, drug sensitivity, antimicrobial therapy, Bangui
- MeSH terms
- Adolescent, Antitubercular Agents, Axilla, Central African Republic, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Lymph Nodes, Male, Microbial Sensitivity Tests, Mycobacterium tuberculosis, Neck, Prospective Studies, Tuberculosis, Lymph Node, Biopsy, Fine-Needle
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