Glucagon-like Peptide-1 (GLP-1) and Protective Effects in Cardiovascular Disease: A New Therapeutic Approach for Myocardial Protection
Open accessAbstract
Glucagon-like peptide-1 (GLP-1) is a member of the proglucagon incretin family implicated in the control of appetite and satiety. GLP-1 has insulinotropic, insulinomimetic, and glucagonostatic effects, thereby exerting multiple complementary actions to lower blood glucose in subjects with type 2 diabetes mellitus. A major advantage over conventional insulin is the fact that the insulinotropic actions of GLP-1 are dependent upon ambient glucose concentration, mitigating the risks of hypoglycemia. Recently, the crucial role of GLP-1 in cardiovascular disease has been suggested in both preclinical and clinical studies. The experimental data indicate GLP-1 and its analogs to have direct effects on the cardiovascular system, in addition to their classic glucoregulatory actions. Clinically, beneficial effects of GLP-1 have also been demonstrated in patients with myocardial ischemia and heart failure. GLP-1 has recently been demonstrated to be a more effective alternative in treating myocardial injury. This paper provides a review on the current evidence supporting the use of GLP-1 in experimental animal models and human trials with the ischemic and non-ischemic heart and discusses their molecular mechanisms and potential as a new therapeutic approach.
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GLP-1RAs treatment reduces body weight and diminishes the risk of cardiovascular disease (CVD).
“The GLP-1RAs treatment reduces body weight and diminishes the risk of cardiovascular disease (CVD) [71,72].”
From The Role of Glp-1 Receptor Agonists in Insulin Resistance with Concomitant Obesity Treatment in Polycystic Ovary Syndrome (2022) · cites this paper as [71]
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- Authors
- Zhao, T. C.
- Affiliations
- Boston University (US)
- Corresponding author
- Zhao, Ting C
- ORCID
- Zhao, Ting C
- Venue
- Cardiovascular Diabetology
- Published
- 2013
- Volume
- 12
- Issue
- 1
- Pages
- 90
- ISSN
- 1475-2840 (ISSN-L)
- PMC
- PMC3700838
- OpenAlex
- W2121231214
- Cited by
- 45
- References
- 79
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 5 · 2021: 1 · 2020: 1 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 8 · 2014: 10 · 2013: 1
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Cardiovascular Diabetology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- National Heart, Lung, and Blood Institute (R01HL089405)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Health Sciences › Medicine › Pharmacology › Apelin-related biomedical research
- Keywords
- glucagon-like peptide-1, GLP-1 receptor agonists, cardioprotection, cardiovascular disease, myocardial ischemia, heart failure, myocardial injury, type 2 diabetes, insulinotropic effect, incretin-based therapy, cardioprotection mechanisms
- MeSH terms
- Glucagon-Like Peptide-1 Receptor, Animals, Antihypertensive Agents, Cardiotonic Agents, Cardiovascular Diseases, Cardiovascular System, Diabetes Mellitus, Type 2, Heart, Humans, Receptors, Glucagon, Anti-Obesity Agents, Glucagon-Like Peptide 1
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