Cited by 45Diabetes Treatment and ManagementCardiac Ischemia and ReperfusionApelin-related biomedical research

Glucagon-like Peptide-1 (GLP-1) and Protective Effects in Cardiovascular Disease: A New Therapeutic Approach for Myocardial Protection

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Zhao, Ting C·2013·Cardiovascular Diabetology

Abstract

Glucagon-like peptide-1 (GLP-1) is a member of the proglucagon incretin family implicated in the control of appetite and satiety. GLP-1 has insulinotropic, insulinomimetic, and glucagonostatic effects, thereby exerting multiple complementary actions to lower blood glucose in subjects with type 2 diabetes mellitus. A major advantage over conventional insulin is the fact that the insulinotropic actions of GLP-1 are dependent upon ambient glucose concentration, mitigating the risks of hypoglycemia. Recently, the crucial role of GLP-1 in cardiovascular disease has been suggested in both preclinical and clinical studies. The experimental data indicate GLP-1 and its analogs to have direct effects on the cardiovascular system, in addition to their classic glucoregulatory actions. Clinically, beneficial effects of GLP-1 have also been demonstrated in patients with myocardial ischemia and heart failure. GLP-1 has recently been demonstrated to be a more effective alternative in treating myocardial injury. This paper provides a review on the current evidence supporting the use of GLP-1 in experimental animal models and human trials with the ischemic and non-ischemic heart and discusses their molecular mechanisms and potential as a new therapeutic approach.

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  1. Swan JW Anker SD Walton C Godsland IF Clark AL Leyva F Stevenson JC Coats AJ Insulin resistance in chronic heart failure: relation to severity and etiology of heart failure J Am Coll Cardiol 1997 30 2 527 532 10.1016/S0735-1097(97)00185-X 9247528 · DOI

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Authors
Zhao, T. C.
Affiliations
Boston University (US)
Corresponding author
Zhao, Ting C
Venue
Cardiovascular Diabetology
Published
2013
Volume
12
Issue
1
Pages
90
ISSN
1475-2840 (ISSN-L)
OpenAlex
W2121231214
Cited by
45
References
79
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 5 · 2021: 1 · 2020: 1 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 8 · 2014: 10 · 2013: 1
FWCI
1.03
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Cardiovascular Diabetology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • American Heart Association
  • National Heart, Lung, and Blood Institute (R01HL089405)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
  • Health Sciences › Medicine › Pharmacology › Apelin-related biomedical research
Keywords
glucagon-like peptide-1, GLP-1 receptor agonists, cardioprotection, cardiovascular disease, myocardial ischemia, heart failure, myocardial injury, type 2 diabetes, insulinotropic effect, incretin-based therapy, cardioprotection mechanisms
MeSH terms
Glucagon-Like Peptide-1 Receptor, Animals, Antihypertensive Agents, Cardiotonic Agents, Cardiovascular Diseases, Cardiovascular System, Diabetes Mellitus, Type 2, Heart, Humans, Receptors, Glucagon, Anti-Obesity Agents, Glucagon-Like Peptide 1

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