The DOI matches its Crossref record; 157 of the 157 references it cites were found in a registry or an index.
Protein folding and conformational stress in microbial cells producing recombinant proteins: a host comparative overview
Open accessAbstract
Different species of microorganisms including yeasts, filamentous fungi and bacteria have been used in the past 25 years for the controlled production of foreign proteins of scientific, pharmacological or industrial interest. A major obstacle for protein production processes and a limit to overall success has been the abundance of misfolded polypeptides, which fail to reach their native conformation. The presence of misfolded or folding-reluctant protein species causes considerable stress in host cells. The characterization of such adverse conditions and the elicited cell responses have permitted to better understand the physiology and molecular biology of conformational stress. Therefore, microbial cell factories for recombinant protein production are depicted here as a source of knowledge that has considerably helped to picture the extremely rich landscape of in vivo protein folding, and the main cellular players of this complex process are described for the most important cell factories used for biotechnological purposes.
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Cited by
Microbial factories for recombinant pharmaceuticals
Ferrer-Miralles, N., Domingo-Espín, J., Corchero, J. L., Vázquez, E., & Villaverde, A. (2009) · Microbial Cell Factories · doi:10.1186/1475-2859-8-17 · Cited by 465
Self-citationCosta, S., Almeida, A., Castro, A., & Domingues, L. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00063 · Cited by 450
Cultivation strategies to enhance productivity of Pichia pastoris: A review
Looser, V., Bruhlmann, B., Bumbak, F., Stenger, C., Costa, M., Camattari, A., Fotiadis, D., & Kovar, K. (2015) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.05.008 · Cited by 350
Engineering of protein secretion in yeast: strategies and impact on protein production
Idiris, A., Tohda, H., Kumagai, H., & Takegawa, K. (2010) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-010-2447-0 · Cited by 324
Comparison of Yeasts as Hosts for Recombinant Protein Production
Vieira Gomes, A. M., Souza Carmo, T., Silva Carvalho, L., Mendonça Bahia, F., & Parachin, N. S. (2018) · Microorganisms · doi:10.3390/microorganisms6020038 · Cited by 308
Metadata
- Authors
- Gasser, B., Saloheimo, M., Rinas, U., Dragosits, M., Rodríguez-Carmona, E., Baumann, K., Giuliani, M., Parrilli, E., Branduardi, P., Lang, C., Porro, D., Ferrer, P., Tutino, M. L., Mattanovich, D., & Villaverde, A.
- Venue
- Microbial Cell Factories
- Published
- 2008-04-04
- Volume
- 7
- Issue
- 1
- Pages
- 11-11
- ISSN
- 1475-2859 (ISSN-L)
- OpenAlex
- W2140237950
- Cited by
- 326
- References
- 157
- FWCI
- 8.19
- Type
- journal article
- Language
- en
- Open access
- gold
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- Gasser, B., Saloheimo, M., Rinas, U., Dragosits, M., Rodríguez-Carmona, E., Baumann, K., Giuliani, M., Parrilli, E., Branduardi, P., Lang, C., Porro, D., Ferrer, P., Tutino, M. L., Mattanovich, D., & Villaverde, A. (2008). Protein folding and conformational stress in microbial cells producing recombinant proteins: a host comparative overview. Microbial Cell Factories. https://doi.org/10.1186/1475-2859-7-11
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