Impaired plasma lipid profiles in acute hepatitis.
Open accessAbstract
The present study examined plasma lipid profiles in thirty patients suffered from acute viral hepatitis. Patients' blood samples were collected at both the debut and recovery of diseases. Thirty sex and age matched normal subjects were included as controls. Plasma total triglycerides (TG), total cholesterol, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein AI (ApoAI), apolipoprotein B (ApoB), lipoprotein (a) (Lp(a)), blood coagulation status including prothrombin complex activity and activated partial tromboplastin time (APTT), and hepatic functions were determined by the automatic biochemical analytical instrument. It demonstrated that plasma levels of total cholesterol, HDL-C and apoAI were significantly lower in the patients at the acute phase of hepatitis than those in normal subjects, whereas plasma levels of TG and LDL-C were obviously higher in the patients than in normal subjects (P < 0.05). Moreover, we demonstrated that patients' plasma levels of total cholesterol, LDL-C, HDL-C and apoAI were lower at the active phase of the diseases than at the recovering phase, which indicating that acute liver damage could significant influence lipid metabolism in vivo. No pathological changes of blood coagulation status occurred in these patients during the study as all selected patients had moderate hepatitis. It may conclude that examinations of plasma lipid profile could be considered as a clinical index to reflect liver damage in the active phase of hepatitis.
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Acute hepatitis may be associated with increased VLDL production and hypertriglyceridemia.
“Acute hepatitis may be associated with increased VLDL production and hypertriglyceridemia (105).”
From Evaluation and Treatment of Hypertriglyceridemia: An Endocrine Society Clinical Practice Guideline (2012) · cites this paper as [105]
The Results (page unavailable) report higher serum triglycerides in acute hepatitis patients than in healthy controls, supporting the elevated-triglyceride part of the claim. The paper does not report increased VLDL production or establish it as the reason for the higher triglycerides. (LLM, conf=0.88)
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Additional file 1 of Oxysterol binding protein (OSBP) contributes to hepatitis E virus replication
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Additional file 2 of Oxysterol binding protein (OSBP) contributes to hepatitis E virus replication
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- Authors
- Luo, L., Pu, X., Wang, Y., & Xu, N.
- Affiliations
- The First People's Hospital of Changzhou (CN)
- Changzhou Third People's Hospital (CN)
- Skåne University Hospital (SE)
- Corresponding author
- Xu, Ning
- Venue
- Lipids in Health and Disease
- Published
- 2010-01-23
- Volume
- 9
- Issue
- 1
- Pages
- 5-5
- ISSN
- 1476-511X (ISSN-L)
- PMC
- PMC2824760
- OpenAlex
- W2171379741
- Cited by
- 27
- References
- 22
- Citations by year
- 2026: 1 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 5 · 2015: 2 · 2013: 1 · 2012: 1
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Lipids in Health and Disease (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Funders
- Soochow University
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- acute viral hepatitis, plasma lipid profile, lipid metabolism, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, apolipoprotein A-I, apolipoprotein B, lipoprotein(a), coagulation, liver injury, disease activity markers
- MeSH terms
- Acute Disease, Adult, Aged, Aged, 80 and over, Apolipoproteins B, Blood Coagulation, Cholesterol, Female, Hepatitis, Humans, Lipids, Male, Middle Aged, Virus Diseases, Apolipoprotein A-I, Lipoprotein(a)
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